5YN6

Crystal structure of MERS-CoV nsp10/nsp16 complex bound to SAM

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004483	molecular_function	mRNA (nucleoside-2'-O-)-methyltransferase activity
B	0003723	molecular_function	RNA binding
B	0008270	molecular_function	zinc ion binding
B	0019079	biological_process	viral genome replication

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	binding site for residue SAM A 401

Chain	Residue
A	ASN43
A	ASN101
A	ASP114
A	CYS115
A	ASP130
A	MET131
A	TYR132
A	HOH502
A	HOH563
A	TYR47
A	GLY71
A	GLY73
A	PRO80
A	GLY81
A	ASN98
A	ASP99
A	LEU100

---

site_id	AC2
Number of Residues	4
Details	binding site for residue ZN B 201

Chain	Residue
B	CYS74
B	CYS77
B	HIS83
B	CYS90

---

site_id	AC3
Number of Residues	4
Details	binding site for residue ZN B 202

Chain	Residue
B	CYS117
B	CYS120
B	CYS128
B	CYS130

---