5C8Y

Crystal structure of T2R-TTL-Plinabulin complex

GO（遺伝子オントロジー）由来の情報

鎖名	GO（遺伝子オントロジー）id	名前空間	内容
A	0000166	molecular_function	nucleotide binding
A	0000226	biological_process	microtubule cytoskeleton organization
A	0000278	biological_process	mitotic cell cycle
A	0005200	molecular_function	structural constituent of cytoskeleton
A	0005525	molecular_function	GTP binding
A	0005737	cellular_component	cytoplasm
A	0005856	cellular_component	cytoskeleton
A	0005874	cellular_component	microtubule
A	0007010	biological_process	cytoskeleton organization
A	0007017	biological_process	microtubule-based process
A	0016787	molecular_function	hydrolase activity
A	0046872	molecular_function	metal ion binding
B	0000166	molecular_function	nucleotide binding
B	0000226	biological_process	microtubule cytoskeleton organization
B	0000278	biological_process	mitotic cell cycle
B	0003924	molecular_function	GTPase activity
B	0005200	molecular_function	structural constituent of cytoskeleton
B	0005525	molecular_function	GTP binding
B	0005737	cellular_component	cytoplasm
B	0005856	cellular_component	cytoskeleton
B	0005874	cellular_component	microtubule
B	0007010	biological_process	cytoskeleton organization
B	0007017	biological_process	microtubule-based process
B	0046872	molecular_function	metal ion binding
C	0000166	molecular_function	nucleotide binding
C	0000226	biological_process	microtubule cytoskeleton organization
C	0000278	biological_process	mitotic cell cycle
C	0005200	molecular_function	structural constituent of cytoskeleton
C	0005525	molecular_function	GTP binding
C	0005737	cellular_component	cytoplasm
C	0005856	cellular_component	cytoskeleton
C	0005874	cellular_component	microtubule
C	0007010	biological_process	cytoskeleton organization
C	0007017	biological_process	microtubule-based process
C	0016787	molecular_function	hydrolase activity
C	0046872	molecular_function	metal ion binding
D	0000166	molecular_function	nucleotide binding
D	0000226	biological_process	microtubule cytoskeleton organization
D	0000278	biological_process	mitotic cell cycle
D	0003924	molecular_function	GTPase activity
D	0005200	molecular_function	structural constituent of cytoskeleton
D	0005525	molecular_function	GTP binding
D	0005737	cellular_component	cytoplasm
D	0005856	cellular_component	cytoskeleton
D	0005874	cellular_component	microtubule
D	0007010	biological_process	cytoskeleton organization
D	0007017	biological_process	microtubule-based process
D	0046872	molecular_function	metal ion binding
E	0031110	biological_process	regulation of microtubule polymerization or depolymerization
F	0036211	biological_process	protein modification process

PDBデータベースに由来する情報

site_id	AC1
残基数	24
詳細	binding site for residue GTP A 501

鎖名	残基
A	GLY10
A	GLY143
A	GLY144
A	THR145
A	GLY146
A	SER178
A	GLU183
A	ASN206
A	TYR224
A	ASN228
A	ILE231
A	GLN11
A	MG502
A	HOH618
A	HOH629
B	LYS252
B	HOH602
A	ALA12
A	GLN15
A	ASP98
A	ALA99
A	ALA100
A	ASN101
A	SER140

---

site_id	AC2
残基数	6
詳細	binding site for residue MG A 502

鎖名	残基
A	ASP69
A	GLU71
A	GTP501
A	HOH629
B	ASN247
B	HOH602

---

site_id	AC3
残基数	4
詳細	binding site for residue CA A 503

鎖名	残基
A	ASP39
A	THR41
A	GLY44
A	GLU55

---

site_id	AC4
残基数	16
詳細	binding site for residue GDP B 501

鎖名	残基
B	GLY10
B	GLN11
B	CYS12
B	GLN15
B	SER138
B	GLY141
B	GLY142
B	THR143
B	GLY144
B	VAL175
B	GLU181
B	ASN204
B	TYR222
B	ASN226
B	MG502
B	HOH604

---

site_id	AC5
残基数	4
詳細	binding site for residue MG B 502

鎖名	残基
B	GLN11
B	ASP177
B	GDP501
C	HOH632

---

site_id	AC6
残基数	6
詳細	binding site for residue MES B 503

鎖名	残基
B	ASP161
B	ARG162
B	ASN195
B	THR196
B	ASP197
B	ARG251

---

site_id	AC7
残基数	18
詳細	binding site for residue PN6 B 504

鎖名	残基
A	THR179
A	HOH604
B	TYR50
B	ASN165
B	GLU198
B	TYR200
B	VAL236
B	THR237
B	CYS239
B	LEU240
B	LEU250
B	LEU253
B	MET257
B	ALA314
B	ALA315
B	ILE316
B	ILE368
B	HOH619

---

site_id	AC8
残基数	24
詳細	binding site for residue GTP C 501

鎖名	残基
C	HOH622
C	HOH626
D	LYS252
C	GLY10
C	GLN11
C	ALA12
C	GLN15
C	ASP98
C	ALA99
C	ALA100
C	ASN101
C	SER140
C	GLY143
C	GLY144
C	THR145
C	GLY146
C	SER178
C	GLU183
C	ASN206
C	TYR224
C	ASN228
C	ILE231
C	MG502
C	HOH621

---

site_id	AC9
残基数	4
詳細	binding site for residue MG C 502

鎖名	残基
C	GLU71
C	GTP501
C	HOH621
C	HOH626

---

site_id	AD1
残基数	4
詳細	binding site for residue CA C 503

鎖名	残基
C	ASP39
C	THR41
C	GLY44
C	GLU55

---

site_id	AD2
残基数	16
詳細	binding site for residue GDP D 501

鎖名	残基
D	GLY10
D	GLN11
D	CYS12
D	GLN15
D	SER138
D	GLY141
D	GLY142
D	THR143
D	GLY144
D	SER176
D	GLU181
D	ASN204
D	TYR222
D	ASN226
D	HOH1202
D	HOH1208

---

site_id	AD3
残基数	18
詳細	binding site for residue PN6 D 502

鎖名	残基
D	GLN134
D	ASN165
D	PHE167
D	GLU198
D	TYR200
D	VAL236
D	THR237
D	CYS239
D	LEU240
D	LEU246
D	LEU253
D	MET257
D	ALA314
D	ALA315
D	ILE316
D	ALA352
D	ILE368
D	HOH1209

---

site_id	AD4
残基数	15
詳細	binding site for residue ACP F 401

鎖名	残基
F	LYS74
F	GLN183
F	LYS184
F	LEU186
F	LYS198
F	ASP200
F	ARG202
F	ARG222
F	HIS239
F	THR241
F	ASN242
F	ASP318
F	ILE330
F	GLU331
F	ASN333

---

UniProtにおけるモチーフ・データベースPROSITEからの機能情報

site_id	PS00227
残基数	7
詳細	TUBULIN Tubulin subunits alpha, beta, and gamma signature. GGGTGSG

鎖名	残基	詳細
A	GLY142-GLY148
B	GLY140-GLY146

---

site_id	PS00228
残基数	4
詳細	TUBULIN_B_AUTOREG Tubulin-beta mRNA autoregulation signal. MREI

鎖名	残基	詳細
B	MET1-ILE4

---

site_id	PS00563
残基数	10
詳細	STATHMIN_1 Stathmin family signature 1. PRRRDpSLEE

鎖名	残基	詳細
E	PRO40-GLU49

---

site_id	PS01041
残基数	10
詳細	STATHMIN_2 Stathmin family signature 2. AEKREHEREV

鎖名	残基	詳細
E	ALA73-VAL82

---

SwissProt/UniProtに記載されている蛋白質分子機能情報

site_id	SWS_FT_FI1
残基数	1
詳細	MOD_RES: Phosphoserine => ECO:0007744|PubMed:22673903

鎖名	残基	詳細
E	SER46

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