4ZHS

Crystal Structure of Aspartate Semialdehyde Dehydrogenase from Trichophyton rubrum

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004073	molecular_function	aspartate-semialdehyde dehydrogenase activity
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006520	biological_process	amino acid metabolic process
A	0008652	biological_process	amino acid biosynthetic process
A	0009086	biological_process	methionine biosynthetic process
A	0009088	biological_process	threonine biosynthetic process
A	0009089	biological_process	lysine biosynthetic process via diaminopimelate
A	0016491	molecular_function	oxidoreductase activity
A	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
A	0046983	molecular_function	protein dimerization activity
A	0050661	molecular_function	NADP binding
A	0051287	molecular_function	NAD binding
A	0071266	biological_process	'de novo' L-methionine biosynthetic process
B	0004073	molecular_function	aspartate-semialdehyde dehydrogenase activity
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006520	biological_process	amino acid metabolic process
B	0008652	biological_process	amino acid biosynthetic process
B	0009086	biological_process	methionine biosynthetic process
B	0009088	biological_process	threonine biosynthetic process
B	0009089	biological_process	lysine biosynthetic process via diaminopimelate
B	0016491	molecular_function	oxidoreductase activity
B	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
B	0046983	molecular_function	protein dimerization activity
B	0050661	molecular_function	NADP binding
B	0051287	molecular_function	NAD binding
B	0071266	biological_process	'de novo' L-methionine biosynthetic process
C	0004073	molecular_function	aspartate-semialdehyde dehydrogenase activity
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006520	biological_process	amino acid metabolic process
C	0008652	biological_process	amino acid biosynthetic process
C	0009086	biological_process	methionine biosynthetic process
C	0009088	biological_process	threonine biosynthetic process
C	0009089	biological_process	lysine biosynthetic process via diaminopimelate
C	0016491	molecular_function	oxidoreductase activity
C	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
C	0046983	molecular_function	protein dimerization activity
C	0050661	molecular_function	NADP binding
C	0051287	molecular_function	NAD binding
C	0071266	biological_process	'de novo' L-methionine biosynthetic process
D	0004073	molecular_function	aspartate-semialdehyde dehydrogenase activity
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006520	biological_process	amino acid metabolic process
D	0008652	biological_process	amino acid biosynthetic process
D	0009086	biological_process	methionine biosynthetic process
D	0009088	biological_process	threonine biosynthetic process
D	0009089	biological_process	lysine biosynthetic process via diaminopimelate
D	0016491	molecular_function	oxidoreductase activity
D	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
D	0046983	molecular_function	protein dimerization activity
D	0050661	molecular_function	NADP binding
D	0051287	molecular_function	NAD binding
D	0071266	biological_process	'de novo' L-methionine biosynthetic process
E	0004073	molecular_function	aspartate-semialdehyde dehydrogenase activity
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006520	biological_process	amino acid metabolic process
E	0008652	biological_process	amino acid biosynthetic process
E	0009086	biological_process	methionine biosynthetic process
E	0009088	biological_process	threonine biosynthetic process
E	0009089	biological_process	lysine biosynthetic process via diaminopimelate
E	0016491	molecular_function	oxidoreductase activity
E	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
E	0046983	molecular_function	protein dimerization activity
E	0050661	molecular_function	NADP binding
E	0051287	molecular_function	NAD binding
E	0071266	biological_process	'de novo' L-methionine biosynthetic process
F	0004073	molecular_function	aspartate-semialdehyde dehydrogenase activity
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006520	biological_process	amino acid metabolic process
F	0008652	biological_process	amino acid biosynthetic process
F	0009086	biological_process	methionine biosynthetic process
F	0009088	biological_process	threonine biosynthetic process
F	0009089	biological_process	lysine biosynthetic process via diaminopimelate
F	0016491	molecular_function	oxidoreductase activity
F	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
F	0046983	molecular_function	protein dimerization activity
F	0050661	molecular_function	NADP binding
F	0051287	molecular_function	NAD binding
F	0071266	biological_process	'de novo' L-methionine biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue SO4 D 401

Chain	Residue
D	ARG114
D	ASN153
D	CYS154
D	LYS211
D	HOH509
D	HOH540

---

site_id	AC2
Number of Residues	4
Details	binding site for residue SO4 C 401

Chain	Residue
C	LYS211
C	ARG114
C	ASN153
C	CYS154

---

site_id	AC3
Number of Residues	6
Details	binding site for residue SO4 B 401

Chain	Residue
B	ARG114
B	ASN153
B	CYS154
B	LYS211
B	HOH514
B	HOH532

---

site_id	AC4
Number of Residues	5
Details	binding site for residue SO4 E 401

Chain	Residue
E	ARG114
E	ASN153
E	CYS154
E	LYS211
E	HOH519

---

site_id	AC5
Number of Residues	5
Details	binding site for residue SO4 A 401

Chain	Residue
A	ARG114
A	ASN153
A	CYS154
A	LYS211
A	HOH546

---

site_id	AC6
Number of Residues	4
Details	binding site for residue SO4 F 401

Chain	Residue
F	LYS111
F	ARG114
F	ASN153
F	CYS154

---

Functional Information from PROSITE/UniProt

site_id	PS01103
Number of Residues	15
Details	ASD Aspartate-semialdehyde dehydrogenase signature. ISvaCnRVpvldGHT

Chain	Residue	Details
D	ILE238-THR252

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	Active site: {"description":"Acyl-thioester intermediate","evidences":[{"source":"PIRSR","id":"PIRSR000148-1","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PIRSR","id":"PIRSR000148-1","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	29
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26869335","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4ZIC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q5ALM0","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"A0A179UL48","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---