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4WUY

Crystal Structure of Protein Lysine Methyltransferase SMYD2 in complex with LLY-507, a Cell-Active, Potent and Selective Inhibitor

GO(遺伝子オントロジー)由来の情報
鎖名GO(遺伝子オントロジー)id名前空間内容
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0000993molecular_functionRNA polymerase II complex binding
A0002039molecular_functionp53 binding
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006325biological_processchromatin organization
A0006338biological_processchromatin remodeling
A0007507biological_processheart development
A0008168molecular_functionmethyltransferase activity
A0008285biological_processnegative regulation of cell population proliferation
A0016278molecular_functionlysine N-methyltransferase activity
A0016279molecular_functionprotein-lysine N-methyltransferase activity
A0018026biological_processpeptidyl-lysine monomethylation
A0018027biological_processpeptidyl-lysine dimethylation
A0032259biological_processmethylation
A0042054molecular_functionhistone methyltransferase activity
A0043516biological_processregulation of DNA damage response, signal transduction by p53 class mediator
A0046872molecular_functionmetal ion binding
A0046975molecular_functionhistone H3K36 methyltransferase activity
A0140938molecular_functionhistone H3 methyltransferase activity
A0140999molecular_functionhistone H3K4 trimethyltransferase activity
A1901796biological_processregulation of signal transduction by p53 class mediator
PDBデータベースに由来する情報
site_idAC1
残基数16
詳細binding site for residue 3UJ A 501
鎖名残基
ALEU141
ATYR240
ASER257
ATYR258
APHE259
AHOH698
AHOH751
AHOH778
ALYS145
AALA177
AASN180
ACYS181
AASN182
AGLY183
APHE184
ATHR185

site_idAC2
残基数18
詳細binding site for residue SAH A 502
鎖名残基
AGLY16
ALYS17
AARG19
AHIS137
ACYS181
AALA203
ALEU204
AASN206
AHIS207
ATYR240
ATYR258
APHE260
AHOH700
AHOH737
AHOH777
AHOH799
AHOH874
AHOH892

site_idAC3
残基数7
詳細binding site for residue GOL A 503
鎖名残基
AVAL76
AGLU77
ALYS140
APHE259
AHOH602
AHOH626
AHOH660

site_idAC4
残基数8
詳細binding site for residue GOL A 504
鎖名残基
AALA38
ATYR39
ATYR41
ALYS115
AHOH742
AHOH750
AHOH762
AHOH828

site_idAC5
残基数7
詳細binding site for residue GOL A 505
鎖名残基
ALEU243
AARG250
ALYS272
ALYS276
AHIS373
ATYR374
APRO375

site_idAC6
残基数4
詳細binding site for residue ZN A 506
鎖名残基
ACYS65
ACYS68
AHIS86
ACYS90

site_idAC7
残基数4
詳細binding site for residue ZN A 507
鎖名残基
ACYS209
ACYS262
ACYS264
ACYS267

site_idAC8
残基数4
詳細binding site for residue ZN A 508
鎖名残基
ACYS52
ACYS55
ACYS74
ACYS78

site_idAC9
残基数2
詳細binding site for residue ZN A 509
鎖名残基
ACYS210
AGLU266

UniProtにおけるモチーフ・データベースPROSITEからの機能情報
site_idPS01360
残基数40
詳細ZF_MYND_1 Zinc finger MYND-type signature. Hcey.Cftrkeglsk........CgrCkqafYCnveCqkedwpm..Hkle.C
鎖名残基詳細
AHIS51-CYS90

SwissProt/UniProtに記載されている蛋白質分子機能情報
site_idSWS_FT_FI1
残基数38
詳細ZN_FING: MYND-type => ECO:0000255|PROSITE-ProRule:PRU00134
鎖名残基詳細
ACYS52-CYS90

site_idSWS_FT_FI2
残基数3
詳細BINDING:
鎖名残基詳細
ALYS17
AASN206
ATYR258

site_idSWS_FT_FI3
残基数8
詳細BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00134
鎖名残基詳細
ACYS52
ACYS55
ACYS65
ACYS68
ACYS74
ACYS78
AHIS86
ACYS90

site_idSWS_FT_FI4
残基数1
詳細BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00190, ECO:0000269|PubMed:21724641
鎖名残基詳細
AHIS137

site_idSWS_FT_FI5
残基数1
詳細MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
鎖名残基詳細
ASER283

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件を2024-09-18に公開中

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