4WUY

Crystal Structure of Protein Lysine Methyltransferase SMYD2 in complex with LLY-507, a Cell-Active, Potent and Selective Inhibitor

GO（遺伝子オントロジー）由来の情報

鎖名	GO（遺伝子オントロジー）id	名前空間	内容
A	0000122	biological_process	negative regulation of transcription by RNA polymerase II
A	0000993	molecular_function	RNA polymerase II complex binding
A	0002039	molecular_function	p53 binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006325	biological_process	chromatin organization
A	0006338	biological_process	chromatin remodeling
A	0007507	biological_process	heart development
A	0008168	molecular_function	methyltransferase activity
A	0008285	biological_process	negative regulation of cell population proliferation
A	0016278	molecular_function	lysine N-methyltransferase activity
A	0016279	molecular_function	protein-lysine N-methyltransferase activity
A	0018026	biological_process	peptidyl-lysine monomethylation
A	0018027	biological_process	peptidyl-lysine dimethylation
A	0032259	biological_process	methylation
A	0042054	molecular_function	histone methyltransferase activity
A	0043516	biological_process	regulation of DNA damage response, signal transduction by p53 class mediator
A	0046872	molecular_function	metal ion binding
A	0046975	molecular_function	histone H3K36 methyltransferase activity
A	0140938	molecular_function	histone H3 methyltransferase activity
A	0140999	molecular_function	histone H3K4 trimethyltransferase activity
A	1901796	biological_process	regulation of signal transduction by p53 class mediator

PDBデータベースに由来する情報

site_id	AC1
残基数	16
詳細	binding site for residue 3UJ A 501

鎖名	残基
A	LEU141
A	TYR240
A	SER257
A	TYR258
A	PHE259
A	HOH698
A	HOH751
A	HOH778
A	LYS145
A	ALA177
A	ASN180
A	CYS181
A	ASN182
A	GLY183
A	PHE184
A	THR185

---

site_id	AC2
残基数	18
詳細	binding site for residue SAH A 502

鎖名	残基
A	GLY16
A	LYS17
A	ARG19
A	HIS137
A	CYS181
A	ALA203
A	LEU204
A	ASN206
A	HIS207
A	TYR240
A	TYR258
A	PHE260
A	HOH700
A	HOH737
A	HOH777
A	HOH799
A	HOH874
A	HOH892

---

site_id	AC3
残基数	7
詳細	binding site for residue GOL A 503

鎖名	残基
A	VAL76
A	GLU77
A	LYS140
A	PHE259
A	HOH602
A	HOH626
A	HOH660

---

site_id	AC4
残基数	8
詳細	binding site for residue GOL A 504

鎖名	残基
A	ALA38
A	TYR39
A	TYR41
A	LYS115
A	HOH742
A	HOH750
A	HOH762
A	HOH828

---

site_id	AC5
残基数	7
詳細	binding site for residue GOL A 505

鎖名	残基
A	LEU243
A	ARG250
A	LYS272
A	LYS276
A	HIS373
A	TYR374
A	PRO375

---

site_id	AC6
残基数	4
詳細	binding site for residue ZN A 506

鎖名	残基
A	CYS65
A	CYS68
A	HIS86
A	CYS90

---

site_id	AC7
残基数	4
詳細	binding site for residue ZN A 507

鎖名	残基
A	CYS209
A	CYS262
A	CYS264
A	CYS267

---

site_id	AC8
残基数	4
詳細	binding site for residue ZN A 508

鎖名	残基
A	CYS52
A	CYS55
A	CYS74
A	CYS78

---

site_id	AC9
残基数	2
詳細	binding site for residue ZN A 509

鎖名	残基
A	CYS210
A	GLU266

---

UniProtにおけるモチーフ・データベースPROSITEからの機能情報

site_id	PS01360
残基数	40
詳細	ZF_MYND_1 Zinc finger MYND-type signature. Hcey.Cftrkeglsk........CgrCkqafYCnveCqkedwpm..Hkle.C

鎖名	残基	詳細
A	HIS51-CYS90

---

SwissProt/UniProtに記載されている蛋白質分子機能情報

site_id	SWS_FT_FI1
残基数	38
詳細	ZN_FING: MYND-type => ECO:0000255|PROSITE-ProRule:PRU00134

鎖名	残基	詳細
A	CYS52-CYS90

---

site_id	SWS_FT_FI2
残基数	3
詳細	BINDING:

鎖名	残基	詳細
A	LYS17
A	ASN206
A	TYR258

---

site_id	SWS_FT_FI3
残基数	8
詳細	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00134

鎖名	残基	詳細
A	CYS52
A	CYS55
A	CYS65
A	CYS68
A	CYS74
A	CYS78
A	HIS86
A	CYS90

---

site_id	SWS_FT_FI4
残基数	1
詳細	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00190, ECO:0000269|PubMed:21724641

鎖名	残基	詳細
A	HIS137

---

site_id	SWS_FT_FI5
残基数	1
詳細	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

鎖名	残基	詳細
A	SER283

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