4UV9

LSD1(KDM1A)-CoREST in complex with 1-Ethyl-Tranylcypromine

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GO(遺伝子オントロジー)由来の情報

鎖名GO(遺伝子オントロジー)id名前空間内容
A1990391cellular_componentDNA repair complex
A0000790cellular_componentnuclear chromatin
A0000784cellular_componentnuclear chromosome, telomeric region
A0005654cellular_componentnucleoplasm
A0005634cellular_componentnucleus
A0032991cellular_componentprotein-containing complex
A0005667cellular_componenttranscription factor complex
A0050681molecular_functionandrogen receptor binding
A0003682molecular_functionchromatin binding
A0032451molecular_functiondemethylase activity
A0019899molecular_functionenzyme binding
A0050660molecular_functionflavin adenine dinucleotide binding
A0032452molecular_functionhistone demethylase activity
A0034648molecular_functionhistone demethylase activity (H3-dimethyl-K4 specific)
A0032453molecular_functionhistone demethylase activity (H3-K4 specific)
A0032454molecular_functionhistone demethylase activity (H3-K9 specific)
A0043426molecular_functionMRF binding
A0030374molecular_functionnuclear receptor transcription coactivator activity
A0016491molecular_functionoxidoreductase activity
A0002039molecular_functionp53 binding
A0001085molecular_functionRNA polymerase II transcription factor binding
A0042162molecular_functiontelomeric DNA binding
A0061752molecular_functiontelomeric repeat-containing RNA binding
A0008134molecular_functiontranscription factor binding
A0044212molecular_functiontranscription regulatory region DNA binding
A0000380biological_processalternative mRNA splicing, via spliceosome
A0007596biological_processblood coagulation
A0071320biological_processcellular response to cAMP
A0071480biological_processcellular response to gamma radiation
A0034644biological_processcellular response to UV
A0021987biological_processcerebral cortex development
A0046098biological_processguanine metabolic process
A0034720biological_processhistone H3-K4 demethylation
A0033169biological_processhistone H3-K9 demethylation
A0055001biological_processmuscle cell development
A0043392biological_processnegative regulation of DNA binding
A0043518biological_processnegative regulation of DNA damage response, signal transduction by p53 class mediator
A0043433biological_processnegative regulation of DNA-binding transcription factor activity
A0051572biological_processnegative regulation of histone H3-K4 methylation
A0051573biological_processnegative regulation of histone H3-K9 methylation
A1902166biological_processnegative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
A0032091biological_processnegative regulation of protein binding
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0045892biological_processnegative regulation of transcription, DNA-templated
A0042551biological_processneuron maturation
A0045793biological_processpositive regulation of cell size
A0035563biological_processpositive regulation of chromatin binding
A0120162biological_processpositive regulation of cold-induced thermogenesis
A0051091biological_processpositive regulation of DNA-binding transcription factor activity
A0033184biological_processpositive regulation of histone ubiquitination
A2000179biological_processpositive regulation of neural precursor cell proliferation
A0002052biological_processpositive regulation of neuroblast proliferation
A0010976biological_processpositive regulation of neuron projection development
A2000648biological_processpositive regulation of stem cell proliferation
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0006482biological_processprotein demethylation
A1903827biological_processregulation of cellular protein localization
A0010569biological_processregulation of double-strand break repair via homologous recombination
A0006357biological_processregulation of transcription by RNA polymerase II
A0060992biological_processresponse to fungicide
B1990391cellular_componentDNA repair complex
B0005654cellular_componentnucleoplasm
B0005634cellular_componentnucleus
B0005667cellular_componenttranscription factor complex
B0017053cellular_componenttranscriptional repressor complex
B0003700molecular_functionDNA-binding transcription factor activity
B0000981molecular_functionDNA-binding transcription factor activity, RNA polymerase II-specific
B0001227molecular_functionDNA-binding transcription repressor activity, RNA polymerase II-specific
B0008134molecular_functiontranscription factor binding
B0044212molecular_functiontranscription regulatory region DNA binding
B0007596biological_processblood coagulation
B0070933biological_processhistone H4 deacetylation
B0045892biological_processnegative regulation of transcription, DNA-templated
B0016032biological_processviral process
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PDBデータベースに由来する情報

site_id残基数詳細
AC134BINDING SITE FOR RESIDUE D70 A 900
鎖名残基
AGLY285
AGLY287
AVAL288
ASER289
ALEU307
AGLU308
AALA309
AARG310
AGLY314
AGLY315
AARG316
ALEU329
AGLY330
AALA331
AMET332
AVAL333
APHE538
ATHR588
AALA589
AVAL590
ATHR624
ALEU625
APRO626
AVAL637
ATRP751
ATRP756
ASER760
ATYR761
AGLY800
AGLU801
AALA809
ATHR810
AVAL811
AALA814

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「HETATM」原子の座標から抽出されたリガンド結合部位

site_id残基数詳細
D70_4uv9_A_90049[(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL (2R,3S,4S)-2,3,4-TRIHYDROXY-5-[(4AS,10AS)-4A-[(1S,3E)-3-IMINO-1-PHENYLPENTYL]-7,8-DIMETHYL-2,4-DIOXO-1,3,4,4A,5,10A-HEXAHYDROBENZO[G]PTERIDIN-10(2H)-YL]PENTYL DIHYDROGEN DIPHOSPHATE binding site
鎖名残基ligand
AILE284-GLY290D70: [(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL (2R,3S,4S)-2,3,4-TRIHYDROXY-5-[(4AS,10AS)-4A-[(1S,3E)-3-IMINO-1-PHENYLPENTYL]-7,8-DIMETHYL-2,4-DIOXO-1,3,4,4A,5,10A-HEXAHYDROBENZO[G]PTERIDIN-10(2H)-YL]PENTYL DIHYDROGEN DIPHOSPHATE
ALEU307-ARG310D70: [(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL (2R,3S,4S)-2,3,4-TRIHYDROXY-5-[(4AS,10AS)-4A-[(1S,3E)-3-IMINO-1-PHENYLPENTYL]-7,8-DIMETHYL-2,4-DIOXO-1,3,4,4A,5,10A-HEXAHYDROBENZO[G]PTERIDIN-10(2H)-YL]PENTYL DIHYDROGEN DIPHOSPHATE
AGLY314-VAL317D70: [(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL (2R,3S,4S)-2,3,4-TRIHYDROXY-5-[(4AS,10AS)-4A-[(1S,3E)-3-IMINO-1-PHENYLPENTYL]-7,8-DIMETHYL-2,4-DIOXO-1,3,4,4A,5,10A-HEXAHYDROBENZO[G]PTERIDIN-10(2H)-YL]PENTYL DIHYDROGEN DIPHOSPHATE
ALEU329-THR335D70: [(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL (2R,3S,4S)-2,3,4-TRIHYDROXY-5-[(4AS,10AS)-4A-[(1S,3E)-3-IMINO-1-PHENYLPENTYL]-7,8-DIMETHYL-2,4-DIOXO-1,3,4,4A,5,10A-HEXAHYDROBENZO[G]PTERIDIN-10(2H)-YL]PENTYL DIHYDROGEN DIPHOSPHATE
APHE538-ALA539D70: [(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL (2R,3S,4S)-2,3,4-TRIHYDROXY-5-[(4AS,10AS)-4A-[(1S,3E)-3-IMINO-1-PHENYLPENTYL]-7,8-DIMETHYL-2,4-DIOXO-1,3,4,4A,5,10A-HEXAHYDROBENZO[G]PTERIDIN-10(2H)-YL]PENTYL DIHYDROGEN DIPHOSPHATE
AHIS564D70: [(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL (2R,3S,4S)-2,3,4-TRIHYDROXY-5-[(4AS,10AS)-4A-[(1S,3E)-3-IMINO-1-PHENYLPENTYL]-7,8-DIMETHYL-2,4-DIOXO-1,3,4,4A,5,10A-HEXAHYDROBENZO[G]PTERIDIN-10(2H)-YL]PENTYL DIHYDROGEN DIPHOSPHATE
ATYR571D70: [(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL (2R,3S,4S)-2,3,4-TRIHYDROXY-5-[(4AS,10AS)-4A-[(1S,3E)-3-IMINO-1-PHENYLPENTYL]-7,8-DIMETHYL-2,4-DIOXO-1,3,4,4A,5,10A-HEXAHYDROBENZO[G]PTERIDIN-10(2H)-YL]PENTYL DIHYDROGEN DIPHOSPHATE
ATHR588-VAL590D70: [(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL (2R,3S,4S)-2,3,4-TRIHYDROXY-5-[(4AS,10AS)-4A-[(1S,3E)-3-IMINO-1-PHENYLPENTYL]-7,8-DIMETHYL-2,4-DIOXO-1,3,4,4A,5,10A-HEXAHYDROBENZO[G]PTERIDIN-10(2H)-YL]PENTYL DIHYDROGEN DIPHOSPHATE
ATHR624-PRO626D70: [(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL (2R,3S,4S)-2,3,4-TRIHYDROXY-5-[(4AS,10AS)-4A-[(1S,3E)-3-IMINO-1-PHENYLPENTYL]-7,8-DIMETHYL-2,4-DIOXO-1,3,4,4A,5,10A-HEXAHYDROBENZO[G]PTERIDIN-10(2H)-YL]PENTYL DIHYDROGEN DIPHOSPHATE
AVAL629D70: [(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL (2R,3S,4S)-2,3,4-TRIHYDROXY-5-[(4AS,10AS)-4A-[(1S,3E)-3-IMINO-1-PHENYLPENTYL]-7,8-DIMETHYL-2,4-DIOXO-1,3,4,4A,5,10A-HEXAHYDROBENZO[G]PTERIDIN-10(2H)-YL]PENTYL DIHYDROGEN DIPHOSPHATE
AVAL637D70: [(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL (2R,3S,4S)-2,3,4-TRIHYDROXY-5-[(4AS,10AS)-4A-[(1S,3E)-3-IMINO-1-PHENYLPENTYL]-7,8-DIMETHYL-2,4-DIOXO-1,3,4,4A,5,10A-HEXAHYDROBENZO[G]PTERIDIN-10(2H)-YL]PENTYL DIHYDROGEN DIPHOSPHATE
ALEU659D70: [(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL (2R,3S,4S)-2,3,4-TRIHYDROXY-5-[(4AS,10AS)-4A-[(1S,3E)-3-IMINO-1-PHENYLPENTYL]-7,8-DIMETHYL-2,4-DIOXO-1,3,4,4A,5,10A-HEXAHYDROBENZO[G]PTERIDIN-10(2H)-YL]PENTYL DIHYDROGEN DIPHOSPHATE
ALYS661D70: [(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL (2R,3S,4S)-2,3,4-TRIHYDROXY-5-[(4AS,10AS)-4A-[(1S,3E)-3-IMINO-1-PHENYLPENTYL]-7,8-DIMETHYL-2,4-DIOXO-1,3,4,4A,5,10A-HEXAHYDROBENZO[G]PTERIDIN-10(2H)-YL]PENTYL DIHYDROGEN DIPHOSPHATE
ATRP751D70: [(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL (2R,3S,4S)-2,3,4-TRIHYDROXY-5-[(4AS,10AS)-4A-[(1S,3E)-3-IMINO-1-PHENYLPENTYL]-7,8-DIMETHYL-2,4-DIOXO-1,3,4,4A,5,10A-HEXAHYDROBENZO[G]PTERIDIN-10(2H)-YL]PENTYL DIHYDROGEN DIPHOSPHATE
ATRP756D70: [(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL (2R,3S,4S)-2,3,4-TRIHYDROXY-5-[(4AS,10AS)-4A-[(1S,3E)-3-IMINO-1-PHENYLPENTYL]-7,8-DIMETHYL-2,4-DIOXO-1,3,4,4A,5,10A-HEXAHYDROBENZO[G]PTERIDIN-10(2H)-YL]PENTYL DIHYDROGEN DIPHOSPHATE
AGLY759-TYR761D70: [(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL (2R,3S,4S)-2,3,4-TRIHYDROXY-5-[(4AS,10AS)-4A-[(1S,3E)-3-IMINO-1-PHENYLPENTYL]-7,8-DIMETHYL-2,4-DIOXO-1,3,4,4A,5,10A-HEXAHYDROBENZO[G]PTERIDIN-10(2H)-YL]PENTYL DIHYDROGEN DIPHOSPHATE
AGLY800-GLU801D70: [(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL (2R,3S,4S)-2,3,4-TRIHYDROXY-5-[(4AS,10AS)-4A-[(1S,3E)-3-IMINO-1-PHENYLPENTYL]-7,8-DIMETHYL-2,4-DIOXO-1,3,4,4A,5,10A-HEXAHYDROBENZO[G]PTERIDIN-10(2H)-YL]PENTYL DIHYDROGEN DIPHOSPHATE
APRO808-HIS812D70: [(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL (2R,3S,4S)-2,3,4-TRIHYDROXY-5-[(4AS,10AS)-4A-[(1S,3E)-3-IMINO-1-PHENYLPENTYL]-7,8-DIMETHYL-2,4-DIOXO-1,3,4,4A,5,10A-HEXAHYDROBENZO[G]PTERIDIN-10(2H)-YL]PENTYL DIHYDROGEN DIPHOSPHATE
AALA814D70: [(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL (2R,3S,4S)-2,3,4-TRIHYDROXY-5-[(4AS,10AS)-4A-[(1S,3E)-3-IMINO-1-PHENYLPENTYL]-7,8-DIMETHYL-2,4-DIOXO-1,3,4,4A,5,10A-HEXAHYDROBENZO[G]PTERIDIN-10(2H)-YL]PENTYL DIHYDROGEN DIPHOSPHATE

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UniProtにおけるモチーフ・データベースPROSITEからの機能情報

site_id残基数詳細
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SwissProt/UniProtに記載されている蛋白質分子機能情報

site_id残基数詳細
SWS_FT_FI15FAD.
鎖名残基詳細
ASER309
AGLU328
AARG330
AARG336
AGLU821

SWS_FT_FI24FAD.
鎖名残基詳細
AMET352-VAL353
ATHR830-VAL831

SWS_FT_FI329FAD (Potential).
鎖名残基詳細
AVAL301-ALA329

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CSAにおける酵素触媒機能の情報

site_id残基数詳細