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4IPX

Analyzing the visible conformational substates of the FK506 binding protein FKBP12

GO(遺伝子オントロジー)由来の情報
鎖名GO(遺伝子オントロジー)id名前空間内容
A0000413biological_processprotein peptidyl-prolyl isomerization
A0003007biological_processheart morphogenesis
A0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
A0005160molecular_functiontransforming growth factor beta receptor binding
A0005515molecular_functionprotein binding
A0005527molecular_functionmacrolide binding
A0005528molecular_functionFK506 binding
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006457biological_processprotein folding
A0006458biological_process'de novo' protein folding
A0014802cellular_componentterminal cisterna
A0016020cellular_componentmembrane
A0016529cellular_componentsarcoplasmic reticulum
A0016853molecular_functionisomerase activity
A0019855molecular_functioncalcium channel inhibitor activity
A0022417biological_processprotein maturation by protein folding
A0030018cellular_componentZ disc
A0030512biological_processnegative regulation of transforming growth factor beta receptor signaling pathway
A0030547molecular_functionsignaling receptor inhibitor activity
A0032092biological_processpositive regulation of protein binding
A0032515biological_processnegative regulation of phosphoprotein phosphatase activity
A0032880biological_processregulation of protein localization
A0032926biological_processnegative regulation of activin receptor signaling pathway
A0033017cellular_componentsarcoplasmic reticulum membrane
A0034713molecular_functiontype I transforming growth factor beta receptor binding
A0042026biological_processprotein refolding
A0042110biological_processT cell activation
A0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
A0044325molecular_functiontransmembrane transporter binding
A0050776biological_processregulation of immune response
A0051280biological_processnegative regulation of release of sequestered calcium ion into cytosol
A0055010biological_processventricular cardiac muscle tissue morphogenesis
A0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
A0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
A0060347biological_processheart trabecula formation
A0070411molecular_functionI-SMAD binding
A0070588biological_processcalcium ion transmembrane transport
A0070697molecular_functionactivin receptor binding
A0097435biological_processsupramolecular fiber organization
A0098562cellular_componentcytoplasmic side of membrane
A1902991biological_processregulation of amyloid precursor protein catabolic process
A1990000biological_processamyloid fibril formation
A1990425cellular_componentryanodine receptor complex
PDBデータベースに由来する情報
site_idAC1
残基数6
詳細BINDING SITE FOR RESIDUE MPD A 201
鎖名残基
ALYS52
AGLN53
AGLU54
APRO88
AGLY89
APRO92

site_idAC2
残基数2
詳細BINDING SITE FOR RESIDUE MPD A 202
鎖名残基
APRO93
AHOH391

SwissProt/UniProtに記載されている蛋白質分子機能情報
site_idSWS_FT_FI1
残基数1
詳細MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P26883
鎖名残基詳細
ALYS52

CSAにおける酵素触媒機能の情報
site_idMCSA1
残基数6
詳細M-CSA 362
鎖名残基詳細
ATYR26electrostatic destabiliser, steric role
APHE36electrostatic destabiliser, polar/non-polar interaction, steric role
AASP37electrostatic stabiliser, steric role
AILE56electrostatic stabiliser, steric role
ATYR82electrostatic stabiliser, steric role
APHE99electrostatic destabiliser, polar/non-polar interaction, steric role

218853

件を2024-04-24に公開中

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