4GJA

Crystal structure of renin in complex with NVP-AYL747 (compound 5)

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Functional Information from GO Data

ChainGOidnamespacecontents
A0045177cellular_componentapical part of cell
A0005737cellular_componentcytoplasm
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005886cellular_componentplasma membrane
A0004190molecular_functionaspartic-type endopeptidase activity
A0005159molecular_functioninsulin-like growth factor receptor binding
A0008233molecular_functionpeptidase activity
A0005102molecular_functionsignaling receptor binding
A0050435biological_processamyloid-beta metabolic process
A0002003biological_processangiotensin maturation
A0048469biological_processcell maturation
A0035690biological_processcellular response to drug
A0042756biological_processdrinking behavior
A0009755biological_processhormone-mediated signaling pathway
A0001822biological_processkidney development
A0008584biological_processmale gonad development
A0001823biological_processmesonephros development
A0006508biological_processproteolysis
A0008217biological_processregulation of blood pressure
A0043408biological_processregulation of MAPK cascade
A0002018biological_processrenin-angiotensin regulation of aldosterone production
A0051591biological_processresponse to cAMP
A0070305biological_processresponse to cGMP
A0035902biological_processresponse to immobilization stress
A0032496biological_processresponse to lipopolysaccharide
B0045177cellular_componentapical part of cell
B0005737cellular_componentcytoplasm
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005886cellular_componentplasma membrane
B0004190molecular_functionaspartic-type endopeptidase activity
B0005159molecular_functioninsulin-like growth factor receptor binding
B0008233molecular_functionpeptidase activity
B0005102molecular_functionsignaling receptor binding
B0050435biological_processamyloid-beta metabolic process
B0002003biological_processangiotensin maturation
B0048469biological_processcell maturation
B0035690biological_processcellular response to drug
B0042756biological_processdrinking behavior
B0009755biological_processhormone-mediated signaling pathway
B0001822biological_processkidney development
B0008584biological_processmale gonad development
B0001823biological_processmesonephros development
B0006508biological_processproteolysis
B0008217biological_processregulation of blood pressure
B0043408biological_processregulation of MAPK cascade
B0002018biological_processrenin-angiotensin regulation of aldosterone production
B0051591biological_processresponse to cAMP
B0070305biological_processresponse to cGMP
B0035902biological_processresponse to immobilization stress
B0032496biological_processresponse to lipopolysaccharide
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Functional Information from PDB Data

site_idNumber of ResiduesDetails
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Functional Information from PDB atom coordinates for the "HETATM" binding sites

site_idNumber of ResiduesDetails
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Functional Information from PROSITE/UniProt

site_idNumber of ResiduesDetails
PS0014148Eukaryotic and viral aspartyl proteases active site.[LIVMFGAC]-[LIVMTADN]-[LIVFSA]-D-[ST]-G-[STAV]-[STAPDENQ]-{GQ}-[LIVMFSTNC]-{EGK}-[LIVMFGTA].
ChainResidueDetails
AVAL29-VAL40
BVAL29-VAL40
AALA212-GLY223
BALA212-GLY223

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Functional Information from SwissProt/UniProt

site_idNumber of ResiduesDetails
SWS_FT_FI12
ChainResidueDetails
AASP38
AASP226

SWS_FT_FI22
ChainResidueDetails
BASP38
BASP226

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Catalytic Information from CSA

site_idNumber of ResiduesDetails
167327
건을2020-08-05부터공개중