Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004032 | molecular_function | aldose reductase (NADPH) activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0008202 | biological_process | steroid metabolic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 34 |
| Details | BINDING SITE FOR RESIDUE NAP A 401 |
| Chain | Residue |
| A | GLY22 |
| A | ASN159 |
| A | GLN180 |
| A | TYR206 |
| A | SER207 |
| A | PRO208 |
| A | PHE209 |
| A | VAL213 |
| A | ARG215 |
| A | ILE257 |
| A | PRO258 |
| A | THR23 |
| A | LYS259 |
| A | SER260 |
| A | THR261 |
| A | ARG265 |
| A | ASN269 |
| A | CIT406 |
| A | HOH561 |
| A | HOH577 |
| A | HOH608 |
| A | HOH612 |
| A | GLY24 |
| A | HOH619 |
| A | HOH629 |
| A | HOH646 |
| A | HOH680 |
| A | HOH708 |
| A | THR27 |
| A | LYS29 |
| A | ASP53 |
| A | TYR58 |
| A | HIS120 |
| A | SER158 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO A 402 |
| Chain | Residue |
| A | TYR173 |
| A | ILE174 |
| A | ARG175 |
| A | HOH653 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO A 403 |
| Chain | Residue |
| A | THR15 |
| A | PRO17 |
| A | GLU80 |
| A | GLU81 |
| A | LEU82 |
| A | HOH647 |
| A | HOH691 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO A 404 |
| Chain | Residue |
| A | ASN74 |
| A | LEU76 |
| A | ASN289 |
| A | ASN291 |
| A | HOH651 |
| A | HOH655 |
| A | HOH723 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 405 |
| Chain | Residue |
| A | ASN159 |
| A | GLN189 |
| A | LEU192 |
| A | ARG293 |
| A | ASN308 |
| A | HOH580 |
| site_id | AC6 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE CIT A 406 |
| Chain | Residue |
| A | GLY24 |
| A | ARG25 |
| A | GLY26 |
| A | TYR58 |
| A | NAP401 |
| A | HOH577 |
| A | HOH619 |
| A | HOH631 |
| A | HOH677 |
Functional Information from PROSITE/UniProt
| site_id | PS00062 |
| Number of Residues | 18 |
| Details | ALDOKETO_REDUCTASE_2 Aldo/keto reductase family signature 2. MqdarqlglARSIGVSNF |
| Chain | Residue | Details |
| A | MET143-PHE160 | |
| site_id | PS00063 |
| Number of Residues | 16 |
| Details | ALDOKETO_REDUCTASE_3 Aldo/keto reductase family putative active site signature. IPKSTNkqRIaQNiDL |
| Chain | Residue | Details |
| A | ILE257-LEU272 | |
| site_id | PS00798 |
| Number of Residues | 18 |
| Details | ALDOKETO_REDUCTASE_1 Aldo/keto reductase family signature 1. GYRHIDTAavyqdEeqVG |
| Chain | Residue | Details |
| A | GLY48-GLY65 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton donor => ECO:0000250 |
| Chain | Residue | Details |
| A | TYR58 | |
| Chain | Residue | Details |
| A | GLY22 | |
| A | ASP53 | |
| A | SER158 | |
| A | ARG215 | |
| A | LYS259 | |
