3OKV
Human Carbonic Anhydrase II A65S, N67Q (CA IX mimic) bound with 2-Ethylestrone 3-O-sulfamate
GO(遺伝子オントロジー)由来の情報
鎖名 | GO(遺伝子オントロジー)id | 名前空間 | 内容 |
A | 0002009 | biological_process | morphogenesis of an epithelium |
A | 0004064 | molecular_function | arylesterase activity |
A | 0004089 | molecular_function | carbonate dehydratase activity |
A | 0005515 | molecular_function | protein binding |
A | 0005737 | cellular_component | cytoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0005886 | cellular_component | plasma membrane |
A | 0006730 | biological_process | one-carbon metabolic process |
A | 0008270 | molecular_function | zinc ion binding |
A | 0015670 | biological_process | carbon dioxide transport |
A | 0016829 | molecular_function | lyase activity |
A | 0018820 | molecular_function | cyanamide hydratase activity |
A | 0032230 | biological_process | positive regulation of synaptic transmission, GABAergic |
A | 0032849 | biological_process | positive regulation of cellular pH reduction |
A | 0038166 | biological_process | angiotensin-activated signaling pathway |
A | 0043209 | cellular_component | myelin sheath |
A | 0044070 | biological_process | regulation of monoatomic anion transport |
A | 0045177 | cellular_component | apical part of cell |
A | 0046872 | molecular_function | metal ion binding |
A | 0046903 | biological_process | secretion |
A | 0051453 | biological_process | regulation of intracellular pH |
A | 0070050 | biological_process | neuron cellular homeostasis |
A | 0070062 | cellular_component | extracellular exosome |
A | 2001150 | biological_process | positive regulation of dipeptide transmembrane transport |
A | 2001225 | biological_process | regulation of chloride transport |
PDBデータベースに由来する情報
site_id | AC1 |
残基数 | 5 |
詳細 | BINDING SITE FOR RESIDUE ZN A 262 |
鎖名 | 残基 |
A | HIS94 |
A | HIS96 |
A | HIS119 |
A | VZ4263 |
A | HOH627 |
site_id | AC2 |
残基数 | 17 |
詳細 | BINDING SITE FOR RESIDUE VZ4 A 263 |
鎖名 | 残基 |
A | HIS94 |
A | HIS96 |
A | HIS119 |
A | PHE131 |
A | LEU198 |
A | THR199 |
A | THR200 |
A | TRP209 |
A | ZN262 |
A | HOH603 |
A | HOH627 |
A | HOH628 |
A | HOH629 |
A | ASN62 |
A | HIS64 |
A | GLN67 |
A | GLN92 |
site_id | AC3 |
残基数 | 10 |
詳細 | BINDING SITE FOR RESIDUE VZ4 A 264 |
鎖名 | 残基 |
A | GLN67 |
A | GLU69 |
A | ILE91 |
A | GLN92 |
A | PHE131 |
A | GLN136 |
A | PRO202 |
A | HOH540 |
A | HOH602 |
A | HOH604 |
site_id | AC4 |
残基数 | 10 |
詳細 | BINDING SITE FOR RESIDUE DMS A 265 |
鎖名 | 残基 |
A | TYR7 |
A | ASP243 |
A | TRP245 |
A | HOH345 |
A | HOH465 |
A | HOH470 |
A | HOH539 |
A | HOH556 |
A | HOH566 |
A | HOH619 |
UniProtにおけるモチーフ・データベースPROSITEからの機能情報
site_id | PS00162 |
残基数 | 17 |
詳細 | ALPHA_CA_1 Alpha-carbonic anhydrases signature. SEHtVdkkkYaaELHLV |
鎖名 | 残基 | 詳細 |
A | SER105-VAL121 |
SwissProt/UniProtに記載されている蛋白質分子機能情報
site_id | SWS_FT_FI1 |
残基数 | 1 |
詳細 | ACT_SITE: Proton donor/acceptor => ECO:0000305|PubMed:15667203, ECO:0000305|PubMed:17330962 |
鎖名 | 残基 | 詳細 |
A | HIS64 |
鎖名 | 残基 | 詳細 |
A | HIS94 |
鎖名 | 残基 | 詳細 |
A | HIS96 | |
A | HIS119 |
site_id | SWS_FT_FI4 |
残基数 | 1 |
詳細 | BINDING: BINDING => ECO:0000269|PubMed:10550681, ECO:0000269|PubMed:19520834 |
鎖名 | 残基 | 詳細 |
A | THR199 |
site_id | SWS_FT_FI5 |
残基数 | 1 |
詳細 | SITE: Fine-tunes the proton-transfer properties of H-64 => ECO:0000305|PubMed:17330962 |
鎖名 | 残基 | 詳細 |
A | TYR7 |
site_id | SWS_FT_FI6 |
残基数 | 2 |
詳細 | SITE: Fine-tunes the proton-transfer properties of H-64; involved in the binding of some activators, including histamine and L-histidine => ECO:0000269|PubMed:16214338, ECO:0000269|PubMed:9265618, ECO:0000305|PubMed:17330962 |
鎖名 | 残基 | 詳細 |
A | ASN62 | |
A | GLN67 |
site_id | SWS_FT_FI7 |
残基数 | 1 |
詳細 | SITE: Involved in the binding of some activators, including histamine and L-histidine => ECO:0000269|PubMed:16214338, ECO:0000269|PubMed:9265618, ECO:0000305|PubMed:17330962 |
鎖名 | 残基 | 詳細 |
A | GLN92 |
site_id | SWS_FT_FI8 |
残基数 | 1 |
詳細 | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P27139 |
鎖名 | 残基 | 詳細 |
A | SER2 |
site_id | SWS_FT_FI9 |
残基数 | 2 |
詳細 | MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569 |
鎖名 | 残基 | 詳細 |
A | SER166 | |
A | SER173 |
CSAにおける酵素触媒機能の情報
site_id | MCSA1 |
残基数 | 6 |
詳細 | M-CSA 216 |
鎖名 | 残基 | 詳細 |
A | HIS64 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
A | HIS94 | metal ligand |
A | HIS96 | metal ligand |
A | GLU106 | activator, electrostatic stabiliser, hydrogen bond acceptor |
A | HIS119 | metal ligand |
A | THR199 | activator, electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, increase nucleophilicity |