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3LL8

Crystal Structure of Calcineurin in Complex with AKAP79 Peptide

GO(遺伝子オントロジー)由来の情報
鎖名GO(遺伝子オントロジー)id名前空間内容
A0016787molecular_functionhydrolase activity
A0033192molecular_functioncalmodulin-dependent protein phosphatase activity
A0097720biological_processcalcineurin-mediated signaling
B0001569biological_processbranching involved in blood vessel morphogenesis
B0001837biological_processepithelial to mesenchymal transition
B0004721molecular_functionphosphoprotein phosphatase activity
B0004723molecular_functioncalcium-dependent protein serine/threonine phosphatase activity
B0005509molecular_functioncalcium ion binding
B0005515molecular_functionprotein binding
B0005516molecular_functioncalmodulin binding
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0005955cellular_componentcalcineurin complex
B0006606biological_processprotein import into nucleus
B0007507biological_processheart development
B0008287cellular_componentprotein serine/threonine phosphatase complex
B0008597molecular_functioncalcium-dependent protein serine/threonine phosphatase regulator activity
B0014044biological_processSchwann cell development
B0016018molecular_functioncyclosporin A binding
B0019902molecular_functionphosphatase binding
B0019904molecular_functionprotein domain specific binding
B0022011biological_processmyelination in peripheral nervous system
B0033173biological_processcalcineurin-NFAT signaling cascade
B0034504biological_processprotein localization to nucleus
B0042383cellular_componentsarcolemma
B0045202cellular_componentsynapse
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0046872molecular_functionmetal ion binding
B0060487biological_processlung epithelial cell differentiation
B0070886biological_processpositive regulation of calcineurin-NFAT signaling cascade
B0097720biological_processcalcineurin-mediated signaling
B0098685cellular_componentSchaffer collateral - CA1 synapse
B0098686cellular_componenthippocampal mossy fiber to CA3 synapse
B0098688cellular_componentparallel fiber to Purkinje cell synapse
B0098693biological_processregulation of synaptic vesicle cycle
B0098794cellular_componentpostsynapse
B0098978cellular_componentglutamatergic synapse
B0099149biological_processregulation of postsynaptic neurotransmitter receptor internalization
B0099170biological_processpostsynaptic modulation of chemical synaptic transmission
B1905665biological_processpositive regulation of calcium ion import across plasma membrane
B1905949biological_processnegative regulation of calcium ion import across plasma membrane
C0016787molecular_functionhydrolase activity
C0033192molecular_functioncalmodulin-dependent protein phosphatase activity
C0097720biological_processcalcineurin-mediated signaling
D0001569biological_processbranching involved in blood vessel morphogenesis
D0001837biological_processepithelial to mesenchymal transition
D0004721molecular_functionphosphoprotein phosphatase activity
D0004723molecular_functioncalcium-dependent protein serine/threonine phosphatase activity
D0005509molecular_functioncalcium ion binding
D0005515molecular_functionprotein binding
D0005516molecular_functioncalmodulin binding
D0005654cellular_componentnucleoplasm
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0005886cellular_componentplasma membrane
D0005955cellular_componentcalcineurin complex
D0006606biological_processprotein import into nucleus
D0007507biological_processheart development
D0008287cellular_componentprotein serine/threonine phosphatase complex
D0008597molecular_functioncalcium-dependent protein serine/threonine phosphatase regulator activity
D0014044biological_processSchwann cell development
D0016018molecular_functioncyclosporin A binding
D0019902molecular_functionphosphatase binding
D0019904molecular_functionprotein domain specific binding
D0022011biological_processmyelination in peripheral nervous system
D0033173biological_processcalcineurin-NFAT signaling cascade
D0034504biological_processprotein localization to nucleus
D0042383cellular_componentsarcolemma
D0045202cellular_componentsynapse
D0045944biological_processpositive regulation of transcription by RNA polymerase II
D0046872molecular_functionmetal ion binding
D0060487biological_processlung epithelial cell differentiation
D0070886biological_processpositive regulation of calcineurin-NFAT signaling cascade
D0097720biological_processcalcineurin-mediated signaling
D0098685cellular_componentSchaffer collateral - CA1 synapse
D0098686cellular_componenthippocampal mossy fiber to CA3 synapse
D0098688cellular_componentparallel fiber to Purkinje cell synapse
D0098693biological_processregulation of synaptic vesicle cycle
D0098794cellular_componentpostsynapse
D0098978cellular_componentglutamatergic synapse
D0099149biological_processregulation of postsynaptic neurotransmitter receptor internalization
D0099170biological_processpostsynaptic modulation of chemical synaptic transmission
D1905665biological_processpositive regulation of calcium ion import across plasma membrane
D1905949biological_processnegative regulation of calcium ion import across plasma membrane
PDBデータベースに由来する情報
site_idAC1
残基数11
詳細BINDING SITE FOR RESIDUE PO4 A 500
鎖名残基
AHIS92
AHOH520
AHOH525
AASP118
AARG122
AASN150
AHIS151
AARG254
AHIS281
AZN505
AFE506

site_idAC2
残基数6
詳細BINDING SITE FOR RESIDUE ZN A 505
鎖名残基
AASP118
AASN150
AHIS199
AHIS281
APO4500
AFE506

site_idAC3
残基数6
詳細BINDING SITE FOR RESIDUE FE A 506
鎖名残基
AASP90
AHIS92
AASP118
APO4500
AZN505
AHOH525

site_idAC4
残基数6
詳細BINDING SITE FOR RESIDUE CA B 501
鎖名残基
BASP30
BASP32
BSER34
BSER36
BGLU41
BHOH421

site_idAC5
残基数6
詳細BINDING SITE FOR RESIDUE CA B 502
鎖名残基
BASP62
BASP64
BASN66
BGLU68
BGLU73
BHOH422

site_idAC6
残基数6
詳細BINDING SITE FOR RESIDUE CA B 503
鎖名残基
BASP99
BASP101
BASP103
BTYR105
BGLU110
BHOH423

site_idAC7
残基数6
詳細BINDING SITE FOR RESIDUE CA B 504
鎖名残基
BASP140
BASP142
BASP144
BARG146
BGLU151
BHOH424

site_idAC8
残基数10
詳細BINDING SITE FOR RESIDUE PO4 C 507
鎖名残基
CHIS92
CASP118
CARG122
CASN150
CHIS151
CARG254
CHIS281
CZN512
CFE513
CHOH601

site_idAC9
残基数6
詳細BINDING SITE FOR RESIDUE ZN C 512
鎖名残基
CASP118
CASN150
CHIS199
CHIS281
CPO4507
CFE513

site_idBC1
残基数6
詳細BINDING SITE FOR RESIDUE FE C 513
鎖名残基
CASP90
CHIS92
CASP118
CPO4507
CZN512
CHOH601

site_idBC2
残基数6
詳細BINDING SITE FOR RESIDUE CA D 508
鎖名残基
DASP30
DASP32
DSER34
DSER36
DGLU41
DHOH415

site_idBC3
残基数6
詳細BINDING SITE FOR RESIDUE CA D 509
鎖名残基
DASP62
DASP64
DASN66
DGLU68
DGLU73
DHOH412

site_idBC4
残基数6
詳細BINDING SITE FOR RESIDUE CA D 510
鎖名残基
DASP99
DASP101
DASP103
DTYR105
DGLU110
DHOH413

site_idBC5
残基数6
詳細BINDING SITE FOR RESIDUE CA D 511
鎖名残基
DASP140
DASP142
DASP144
DARG146
DGLU151
DHOH414

UniProtにおけるモチーフ・データベースPROSITEからの機能情報
site_idPS00018
残基数13
詳細EF_HAND_1 EF-hand calcium-binding domain. DLDNSGSLSveEF
鎖名残基詳細
BASP30-PHE42
BASP62-PHE74
BASP99-LEU111
BASP140-PHE152

site_idPS00125
残基数6
詳細SER_THR_PHOSPHATASE Serine/threonine specific protein phosphatases signature. LRGNHE
鎖名残基詳細
ALEU147-GLU152

SwissProt/UniProtに記載されている蛋白質分子機能情報
site_idSWS_FT_FI1
残基数30
詳細BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:12218175, ECO:0000269|PubMed:12357034, ECO:0000269|PubMed:17498738, ECO:0000269|PubMed:22343722, ECO:0000269|PubMed:23468591, ECO:0000269|PubMed:26794871, ECO:0000269|PubMed:27974827, ECO:0000269|PubMed:8524402, ECO:0007744|PDB:1AUI, ECO:0007744|PDB:1M63, ECO:0007744|PDB:1MF8, ECO:0007744|PDB:2P6B, ECO:0007744|PDB:3LL8, ECO:0007744|PDB:4F0Z, ECO:0007744|PDB:4OR9, ECO:0007744|PDB:4ORA, ECO:0007744|PDB:4ORC, ECO:0007744|PDB:5SVE
鎖名残基詳細
BASP30
BGLU73
BASP140
BASP142
BASP144
BARG146
BGLU151
DASP30
DASP32
DSER34
DSER36
BASP32
DGLU41
DASP62
DASP64
DASN66
DGLU68
DGLU73
DASP140
DASP142
DASP144
DARG146
BSER34
DGLU151
BSER36
BGLU41
BASP62
BASP64
BASN66
BGLU68

site_idSWS_FT_FI2
残基数10
詳細BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:12218175, ECO:0000269|PubMed:12357034, ECO:0000269|PubMed:17498738, ECO:0000269|PubMed:22343722, ECO:0000269|PubMed:23468591, ECO:0000269|PubMed:26794871, ECO:0000269|PubMed:27974827, ECO:0000269|PubMed:31375679, ECO:0000269|PubMed:8524402, ECO:0000312|PDB:6NUC, ECO:0007744|PDB:1AUI, ECO:0007744|PDB:1M63, ECO:0007744|PDB:1MF8, ECO:0007744|PDB:2P6B, ECO:0007744|PDB:3LL8, ECO:0007744|PDB:4F0Z, ECO:0007744|PDB:4OR9, ECO:0007744|PDB:4ORA, ECO:0007744|PDB:4ORC, ECO:0007744|PDB:5SVE
鎖名残基詳細
BASP99
DGLU110
CHIS199
CHIS281
BASP101
BASP103
BTYR105
BGLU110
DASP99
DASP101
DASP103
DTYR105

site_idSWS_FT_FI3
残基数4
詳細SITE: Interaction with PxVP motif in substrates of the catalytic subunit => ECO:0000269|PubMed:23468591
鎖名残基詳細
BMET117
BASN121
DMET117
DASN121

site_idSWS_FT_FI4
残基数2
詳細MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:Q63810
鎖名残基詳細
BTYR105
DTYR105

CSAにおける酵素触媒機能の情報
site_idMCSA1
残基数10
詳細M-CSA 406
鎖名残基詳細
AASP90metal ligand
AHIS281metal ligand
AHIS92metal ligand
AASP118metal ligand
AASP121electrostatic stabiliser
AARG122transition state stabiliser
AASN150metal ligand
AHIS151proton shuttle (general acid/base)
AHIS199metal ligand
AARG254transition state stabiliser

site_idMCSA2
残基数10
詳細M-CSA 406
鎖名残基詳細
CASP90metal ligand
CHIS281metal ligand
CHIS92metal ligand
CASP118metal ligand
CASP121electrostatic stabiliser
CARG122transition state stabiliser
CASN150metal ligand
CHIS151proton shuttle (general acid/base)
CHIS199metal ligand
CARG254transition state stabiliser

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件を2024-05-01に公開中

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