3FM8
Crystal structure of full length centaurin alpha-1 bound with the FHA domain of KIF13B (CAPRI target)
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0005911 | cellular_component | cell-cell junction |
B | 0005911 | cellular_component | cell-cell junction |
C | 0005096 | molecular_function | GTPase activator activity |
C | 0005515 | molecular_function | protein binding |
C | 0005547 | molecular_function | phosphatidylinositol-3,4,5-trisphosphate binding |
C | 0005634 | cellular_component | nucleus |
C | 0005737 | cellular_component | cytoplasm |
C | 0005829 | cellular_component | cytosol |
C | 0005886 | cellular_component | plasma membrane |
C | 0007166 | biological_process | cell surface receptor signaling pathway |
C | 0043087 | biological_process | regulation of GTPase activity |
C | 0043231 | cellular_component | intracellular membrane-bounded organelle |
C | 0043533 | molecular_function | inositol 1,3,4,5 tetrakisphosphate binding |
C | 0043547 | biological_process | positive regulation of GTPase activity |
C | 0046872 | molecular_function | metal ion binding |
C | 1902936 | molecular_function | phosphatidylinositol bisphosphate binding |
D | 0005096 | molecular_function | GTPase activator activity |
D | 0005515 | molecular_function | protein binding |
D | 0005547 | molecular_function | phosphatidylinositol-3,4,5-trisphosphate binding |
D | 0005634 | cellular_component | nucleus |
D | 0005737 | cellular_component | cytoplasm |
D | 0005829 | cellular_component | cytosol |
D | 0005886 | cellular_component | plasma membrane |
D | 0007166 | biological_process | cell surface receptor signaling pathway |
D | 0043087 | biological_process | regulation of GTPase activity |
D | 0043231 | cellular_component | intracellular membrane-bounded organelle |
D | 0043533 | molecular_function | inositol 1,3,4,5 tetrakisphosphate binding |
D | 0043547 | biological_process | positive regulation of GTPase activity |
D | 0046872 | molecular_function | metal ion binding |
D | 1902936 | molecular_function | phosphatidylinositol bisphosphate binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN C 401 |
Chain | Residue |
C | CYS21 |
C | CYS24 |
C | CYS41 |
C | CYS44 |
site_id | AC2 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE SO4 C 375 |
Chain | Residue |
C | ARG156 |
C | LYS3 |
C | GLU4 |
C | ARG5 |
C | ARG6 |
C | TRP65 |
site_id | AC3 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN D 401 |
Chain | Residue |
D | CYS21 |
D | CYS24 |
D | CYS41 |
D | CYS44 |
site_id | AC4 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE SO4 D 375 |
Chain | Residue |
D | HIS193 |
D | GLU213 |
D | ASP214 |
D | GLY215 |
D | HOH422 |
D | HOH434 |
site_id | AC5 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 D 376 |
Chain | Residue |
D | LYS261 |
D | ARG273 |
D | TYR284 |
D | ARG294 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 46 |
Details | ZN_FING: C4-type => ECO:0000255|PROSITE-ProRule:PRU00288 |
Chain | Residue | Details |
C | CYS21-CYS44 | |
D | CYS21-CYS44 |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine; by PKC => ECO:0000269|PubMed:12893243 |
Chain | Residue | Details |
C | SER87 | |
D | SER87 |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861 |
Chain | Residue | Details |
C | LYS272 | |
D | LYS272 |
site_id | SWS_FT_FI4 |
Number of Residues | 2 |
Details | MOD_RES: Phosphothreonine; by PKC => ECO:0000269|PubMed:12893243 |
Chain | Residue | Details |
C | THR276 | |
D | THR276 |