3EM6
Crystal structure of I50L/A71V mutant of hiv-1 protease in complex with inhibitor darunavir
GO（遺伝子オントロジー）由来の情報
PDBデータベースに由来する情報
| site_id | AC1 |
| 残基数 | 16 |
| 詳細 | BINDING SITE FOR RESIDUE 017 A 200 |
| 鎖名 | 残基 |
| A | ASP25 |
| B | ASP25 |
| B | GLY27 |
| B | ALA28 |
| B | ASP30 |
| B | GLY48 |
| B | GLY49 |
| B | PRO81 |
| A | GLY27 |
| A | ALA28 |
| A | ASP29 |
| A | ASP30 |
| A | GLY48 |
| A | GLY49 |
| A | LEU50 |
| A | HOH613 |
| site_id | AC2 |
| 残基数 | 3 |
| 詳細 | BINDING SITE FOR RESIDUE PO4 A 502 |
| 鎖名 | 残基 |
| A | LYS7 |
| A | ARG8 |
| A | HOH700 |
| site_id | AC3 |
| 残基数 | 6 |
| 詳細 | BINDING SITE FOR RESIDUE PO4 A 504 |
| 鎖名 | 残基 |
| A | MET36 |
| A | ASN37 |
| A | HOH620 |
| A | HOH624 |
| B | PRO39 |
| B | GLY40 |
| site_id | AC4 |
| 残基数 | 5 |
| 詳細 | BINDING SITE FOR RESIDUE PO4 A 505 |
| 鎖名 | 残基 |
| A | LYS20 |
| A | GLU21 |
| A | ASN83 |
| A | HOH642 |
| A | HOH694 |
| site_id | AC5 |
| 残基数 | 4 |
| 詳細 | BINDING SITE FOR RESIDUE ACT A 606 |
| 鎖名 | 残基 |
| A | ARG14 |
| A | GLY16 |
| A | GLY17 |
| B | GLY16 |
| site_id | AC6 |
| 残基数 | 4 |
| 詳細 | BINDING SITE FOR RESIDUE PO4 B 503 |
| 鎖名 | 残基 |
| A | HIS69 |
| A | LYS70 |
| B | PRO1 |
| B | HOH335 |
| site_id | AC7 |
| 残基数 | 4 |
| 詳細 | BINDING SITE FOR RESIDUE PO4 B 506 |
| 鎖名 | 残基 |
| A | ARG87 |
| B | TRP6 |
| B | LYS7 |
| B | ARG8 |
| site_id | AC8 |
| 残基数 | 4 |
| 詳細 | BINDING SITE FOR RESIDUE ACT B 603 |
| 鎖名 | 残基 |
| B | GLY73 |
| B | THR74 |
| B | ASN88 |
| B | GLN92 |
| site_id | AC9 |
| 残基数 | 4 |
| 詳細 | BINDING SITE FOR RESIDUE ACT B 605 |
| 鎖名 | 残基 |
| B | LYS20 |
| B | GLU21 |
| B | ASN83 |
| B | HOH637 |
UniProtにおけるモチーフ・データベースPROSITEからの機能情報
| site_id | PS00141 |
| 残基数 | 12 |
| 詳細 | ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. ALLDTGADDTVL |
| 鎖名 | 残基 | 詳細 |
| A | ALA22-LEU33 |
SwissProt/UniProtに記載されている蛋白質分子機能情報
| site_id | SWS_FT_FI1 |
| 残基数 | 2 |
| 詳細 | ACT_SITE: For protease activity; shared with dimeric partner => ECO:0000255|PROSITE-ProRule:PRU10094 |
| 鎖名 | 残基 | 詳細 |
| A | ASP25 | |
| B | ASP25 |
| site_id | SWS_FT_FI2 |
| 残基数 | 2 |
| 詳細 | SITE: Cleavage; by viral protease => ECO:0000250 |
| 鎖名 | 残基 | 詳細 |
| A | PHE99 | |
| B | PHE99 |
