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3BXN

The high resolution crystal structure of HLA-B*1402 complexed with a Cathepsin A signal sequence peptide, pCatA

GO(遺伝子オントロジー)由来の情報
鎖名GO(遺伝子オントロジー)id名前空間内容
A0001916biological_processpositive regulation of T cell mediated cytotoxicity
A0002476biological_processantigen processing and presentation of endogenous peptide antigen via MHC class Ib
A0002486biological_processantigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent
A0005102molecular_functionsignaling receptor binding
A0005615cellular_componentextracellular space
A0006955biological_processimmune response
A0009897cellular_componentexternal side of plasma membrane
A0042605molecular_functionpeptide antigen binding
B0000139cellular_componentGolgi membrane
B0001913biological_processT cell mediated cytotoxicity
B0001916biological_processpositive regulation of T cell mediated cytotoxicity
B0002237biological_processresponse to molecule of bacterial origin
B0002376biological_processimmune system process
B0002474biological_processantigen processing and presentation of peptide antigen via MHC class I
B0002481biological_processantigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
B0002502biological_processpeptide antigen assembly with MHC class I protein complex
B0002503biological_processpeptide antigen assembly with MHC class II protein complex
B0002726biological_processpositive regulation of T cell cytokine production
B0005198molecular_functionstructural molecule activity
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005765cellular_componentlysosomal membrane
B0005783cellular_componentendoplasmic reticulum
B0005788cellular_componentendoplasmic reticulum lumen
B0005794cellular_componentGolgi apparatus
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0005925cellular_componentfocal adhesion
B0006826biological_processiron ion transport
B0006879biological_processintracellular iron ion homeostasis
B0006955biological_processimmune response
B0007608biological_processsensory perception of smell
B0007611biological_processlearning or memory
B0009897cellular_componentexternal side of plasma membrane
B0009986cellular_componentcell surface
B0010977biological_processnegative regulation of neuron projection development
B0012507cellular_componentER to Golgi transport vesicle membrane
B0016020cellular_componentmembrane
B0019885biological_processantigen processing and presentation of endogenous peptide antigen via MHC class I
B0019886biological_processantigen processing and presentation of exogenous peptide antigen via MHC class II
B0023026molecular_functionMHC class II protein complex binding
B0030670cellular_componentphagocytic vesicle membrane
B0031901cellular_componentearly endosome membrane
B0031902cellular_componentlate endosome membrane
B0031905cellular_componentearly endosome lumen
B0032092biological_processpositive regulation of protein binding
B0033077biological_processT cell differentiation in thymus
B0034756biological_processregulation of iron ion transport
B0035580cellular_componentspecific granule lumen
B0042026biological_processprotein refolding
B0042605molecular_functionpeptide antigen binding
B0042612cellular_componentMHC class I protein complex
B0042613cellular_componentMHC class II protein complex
B0042802molecular_functionidentical protein binding
B0042803molecular_functionprotein homodimerization activity
B0042824cellular_componentMHC class I peptide loading complex
B0045646biological_processregulation of erythrocyte differentiation
B0048260biological_processpositive regulation of receptor-mediated endocytosis
B0050680biological_processnegative regulation of epithelial cell proliferation
B0050768biological_processnegative regulation of neurogenesis
B0050778biological_processpositive regulation of immune response
B0050870biological_processpositive regulation of T cell activation
B0051289biological_processprotein homotetramerization
B0055038cellular_componentrecycling endosome membrane
B0060586biological_processmulticellular organismal-level iron ion homeostasis
B0070062cellular_componentextracellular exosome
B0071281biological_processcellular response to iron ion
B0071283biological_processcellular response to iron(III) ion
B0071316biological_processcellular response to nicotine
B1900121biological_processnegative regulation of receptor binding
B1900122biological_processpositive regulation of receptor binding
B1904434biological_processpositive regulation of ferrous iron binding
B1904437biological_processpositive regulation of transferrin receptor binding
B1904724cellular_componenttertiary granule lumen
B1990000biological_processamyloid fibril formation
B1990712cellular_componentHFE-transferrin receptor complex
B2000774biological_processpositive regulation of cellular senescence
B2000978biological_processnegative regulation of forebrain neuron differentiation
PDBデータベースに由来する情報
site_idAC1
残基数3
詳細BINDING SITE FOR RESIDUE GOL B 501
鎖名残基
AHIS93
AASP119
BILE1

site_idAC2
残基数3
詳細BINDING SITE FOR RESIDUE GOL A 502
鎖名残基
AGLU166
ATRP167
AARG170

site_idAC3
残基数4
詳細BINDING SITE FOR RESIDUE GOL B 503
鎖名残基
BARG97
BASP76
BTRP95
BASP96

site_idAC4
残基数5
詳細BINDING SITE FOR RESIDUE GOL A 504
鎖名残基
APHE8
ATYR27
AASP29
AASP30
BTYR63

UniProtにおけるモチーフ・データベースPROSITEからの機能情報
site_idPS00290
残基数7
詳細IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCHVQH
鎖名残基詳細
ATYR257-HIS263
BTYR78-HIS84

SwissProt/UniProtに記載されている蛋白質分子機能情報
site_idSWS_FT_FI1
残基数1
詳細MOD_RES: Pyrrolidone carboxylic acid; in form pI 5.3 => ECO:0000269|PubMed:7554280
鎖名残基詳細
BGLN2

site_idSWS_FT_FI2
残基数1
詳細CARBOHYD: N-linked (Glc) (glycation) isoleucine; in hemodialysis-associated amyloidosis => ECO:0000269|PubMed:7918443
鎖名残基詳細
BILE1

site_idSWS_FT_FI3
残基数6
詳細CARBOHYD: N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:7918443
鎖名残基詳細
BLYS19
BLYS41
BLYS48
BLYS58
BLYS91
BLYS94

218853

件を2024-04-24に公開中

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