2WF1
Human BACE-1 in complex with 7-ethyl-N-((1S,2R)-2-hydroxy-3-(((3-(methyloxy)phenyl(methyl)amino)-1-(phenylmethyl)propyl)-1-methyl-3,4- dihydro-1H-(1,2,5)thiadiazepino(3,4,5-hi)indole-9-carboxamide 2,2- dioxide
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004190 | molecular_function | aspartic-type endopeptidase activity |
A | 0006508 | biological_process | proteolysis |
A | 0016020 | cellular_component | membrane |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 20 |
Details | BINDING SITE FOR RESIDUE ZY1 A 2000 |
Chain | Residue |
A | GLY72 |
A | GLN134 |
A | PHE169 |
A | ILE179 |
A | ASP289 |
A | GLY291 |
A | THR292 |
A | THR293 |
A | ASN294 |
A | ARG296 |
A | SER386 |
A | GLN73 |
A | HOH2371 |
A | GLY74 |
A | ASP93 |
A | GLY95 |
A | SER96 |
A | PRO131 |
A | TYR132 |
A | THR133 |
Functional Information from PROSITE/UniProt
site_id | PS00141 |
Number of Residues | 12 |
Details | ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. ILVDTGSSNFAV |
Chain | Residue | Details |
A | ILE90-VAL101 | |
Functional Information from SwissProt/UniProt
Chain | Residue | Details |
A | ASP93 | |
A | ASP289 | |
Chain | Residue | Details |
A | LYS126 | |
A | LYS275 | |
A | LYS279 | |
A | LYS285 | |
A | LYS299 | |
A | LYS300 | |
A | LYS307 | |
site_id | SWS_FT_FI3 |
Number of Residues | 4 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
Chain | Residue | Details |
A | GLN153 | |
A | GLN172 | |
A | GLN223 | |
A | GLN354 | |