2RFI
Crystal structure of catalytic domain of human euchromatic histone methyltransferase 1 in complex with SAH and dimethylated H3K9 peptide
GO（遺伝子オントロジー）由来の情報
| 鎖名 | GO（遺伝子オントロジー）id | 名前空間 | 内容 |
| A | 0002039 | molecular_function | p53 binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0016279 | molecular_function | protein-lysine N-methyltransferase activity |
| A | 0042054 | molecular_function | histone methyltransferase activity |
| A | 0046974 | molecular_function | histone H3K9 methyltransferase activity |
| B | 0002039 | molecular_function | p53 binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0016279 | molecular_function | protein-lysine N-methyltransferase activity |
| B | 0042054 | molecular_function | histone methyltransferase activity |
| B | 0046974 | molecular_function | histone H3K9 methyltransferase activity |
PDBデータベースに由来する情報
| site_id | AC1 |
| 残基数 | 4 |
| 詳細 | BINDING SITE FOR RESIDUE ZN A 501 |
| 鎖名 | 残基 |
| A | CYS1031 |
| A | CYS1044 |
| A | CYS1074 |
| A | CYS1078 |
| site_id | AC2 |
| 残基数 | 4 |
| 詳細 | BINDING SITE FOR RESIDUE ZN A 502 |
| 鎖名 | 残基 |
| A | CYS1037 |
| A | CYS1074 |
| A | CYS1080 |
| A | CYS1084 |
| site_id | AC3 |
| 残基数 | 4 |
| 詳細 | BINDING SITE FOR RESIDUE ZN A 503 |
| 鎖名 | 残基 |
| A | CYS1033 |
| A | CYS1037 |
| A | CYS1042 |
| A | CYS1031 |
| site_id | AC4 |
| 残基数 | 4 |
| 詳細 | BINDING SITE FOR RESIDUE ZN A 504 |
| 鎖名 | 残基 |
| A | CYS1172 |
| A | CYS1225 |
| A | CYS1227 |
| A | CYS1232 |
| site_id | AC5 |
| 残基数 | 4 |
| 詳細 | BINDING SITE FOR RESIDUE ZN B 501 |
| 鎖名 | 残基 |
| B | CYS1031 |
| B | CYS1044 |
| B | CYS1074 |
| B | CYS1078 |
| site_id | AC6 |
| 残基数 | 4 |
| 詳細 | BINDING SITE FOR RESIDUE ZN B 502 |
| 鎖名 | 残基 |
| B | CYS1037 |
| B | CYS1074 |
| B | CYS1080 |
| B | CYS1084 |
| site_id | AC7 |
| 残基数 | 4 |
| 詳細 | BINDING SITE FOR RESIDUE ZN B 503 |
| 鎖名 | 残基 |
| B | CYS1031 |
| B | CYS1033 |
| B | CYS1037 |
| B | CYS1042 |
| site_id | AC8 |
| 残基数 | 4 |
| 詳細 | BINDING SITE FOR RESIDUE ZN B 504 |
| 鎖名 | 残基 |
| B | CYS1172 |
| B | CYS1225 |
| B | CYS1227 |
| B | CYS1232 |
| site_id | AC9 |
| 残基数 | 21 |
| 詳細 | BINDING SITE FOR RESIDUE SAH A 101 |
| 鎖名 | 残基 |
| A | MET1105 |
| A | TRP1107 |
| A | SER1141 |
| A | TYR1142 |
| A | ARG1166 |
| A | PHE1167 |
| A | ASN1169 |
| A | HIS1170 |
| A | TYR1211 |
| A | PHE1215 |
| A | PHE1223 |
| A | CYS1225 |
| A | ARG1226 |
| A | HOH1322 |
| A | HOH1357 |
| A | HOH1390 |
| A | HOH1446 |
| A | HOH1460 |
| A | HOH1462 |
| A | HOH1472 |
| P | MLY7 |
| site_id | BC1 |
| 残基数 | 11 |
| 詳細 | BINDING SITE FOR RESIDUE SAH A 102 |
| 鎖名 | 残基 |
| A | HOH1517 |
| B | MET1105 |
| B | TRP1107 |
| B | ARG1166 |
| B | ASN1169 |
| B | HIS1170 |
| B | TYR1211 |
| B | PHE1223 |
| B | SER1224 |
| B | CYS1225 |
| B | ARG1226 |
SwissProt/UniProtに記載されている蛋白質分子機能情報
| site_id | SWS_FT_FI1 |
| 残基数 | 26 |
| 詳細 | BINDING: |
| 鎖名 | 残基 | 詳細 |
| A | GLU1062 | |
| A | VAL1136 | |
| A | GLU1173 | |
| A | LEU1200 | |
| A | ALA1203 | |
| B | GLU1062 | |
| B | ASN1064 | |
| B | PRO1068 | |
| B | GLU1073 | |
| B | ASN1075 | |
| B | MET1105 | |
| A | ASN1064 | |
| B | VAL1109 | |
| B | SER1111 | |
| B | ILE1115 | |
| B | VAL1136 | |
| B | GLU1173 | |
| B | LEU1200 | |
| B | ALA1203 | |
| A | PRO1068 | |
| A | GLU1073 | |
| A | ASN1075 | |
| A | MET1105 | |
| A | VAL1109 | |
| A | SER1111 | |
| A | ILE1115 |
| site_id | SWS_FT_FI2 |
| 残基数 | 2 |
| 詳細 | SITE: Histone H3K9me binding => ECO:0000269|PubMed:18264113, ECO:0000269|PubMed:20084102 |
| 鎖名 | 残基 | 詳細 |
| A | CYS1155 | |
| B | CYS1155 |
| site_id | SWS_FT_FI3 |
| 残基数 | 4 |
| 詳細 | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| 鎖名 | 残基 | 詳細 |
| A | PRO1004 | |
| A | SER1048 | |
| B | PRO1004 | |
| B | SER1048 |
