2R9R
Shaker family voltage dependent potassium channel (kv1.2-kv2.1 paddle chimera channel) in association with beta subunit
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0002244 | biological_process | hematopoietic progenitor cell differentiation |
A | 0004033 | molecular_function | aldo-keto reductase (NADPH) activity |
A | 0005249 | molecular_function | voltage-gated potassium channel activity |
A | 0005515 | molecular_function | protein binding |
A | 0005737 | cellular_component | cytoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0005856 | cellular_component | cytoskeleton |
A | 0005874 | cellular_component | microtubule |
A | 0005886 | cellular_component | plasma membrane |
A | 0006813 | biological_process | potassium ion transport |
A | 0008076 | cellular_component | voltage-gated potassium channel complex |
A | 0009898 | cellular_component | cytoplasmic side of plasma membrane |
A | 0014069 | cellular_component | postsynaptic density |
A | 0015459 | molecular_function | potassium channel regulator activity |
A | 0016020 | cellular_component | membrane |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0030424 | cellular_component | axon |
A | 0034705 | cellular_component | potassium channel complex |
A | 0043005 | cellular_component | neuron projection |
A | 0043194 | cellular_component | axon initial segment |
A | 0043679 | cellular_component | axon terminus |
A | 0044224 | cellular_component | juxtaparanode region of axon |
A | 0044325 | molecular_function | transmembrane transporter binding |
A | 0044877 | molecular_function | protein-containing complex binding |
A | 0045202 | cellular_component | synapse |
A | 0045445 | biological_process | myoblast differentiation |
A | 0050905 | biological_process | neuromuscular process |
A | 0055085 | biological_process | transmembrane transport |
A | 0055114 | biological_process | obsolete oxidation-reduction process |
A | 0070995 | biological_process | NADPH oxidation |
A | 0071805 | biological_process | potassium ion transmembrane transport |
A | 0098839 | cellular_component | postsynaptic density membrane |
A | 0098900 | biological_process | regulation of action potential |
A | 0098978 | cellular_component | glutamatergic synapse |
A | 1901379 | biological_process | regulation of potassium ion transmembrane transport |
A | 1990002 | molecular_function | methylglyoxal reductase (NADPH) (acetol producing) activity |
A | 1990031 | cellular_component | pinceau fiber |
A | 2000008 | biological_process | regulation of protein localization to cell surface |
B | 0005216 | molecular_function | monoatomic ion channel activity |
B | 0005249 | molecular_function | voltage-gated potassium channel activity |
B | 0006811 | biological_process | monoatomic ion transport |
B | 0006813 | biological_process | potassium ion transport |
B | 0008076 | cellular_component | voltage-gated potassium channel complex |
B | 0016020 | cellular_component | membrane |
B | 0051260 | biological_process | protein homooligomerization |
B | 0055085 | biological_process | transmembrane transport |
G | 0002244 | biological_process | hematopoietic progenitor cell differentiation |
G | 0004033 | molecular_function | aldo-keto reductase (NADPH) activity |
G | 0005249 | molecular_function | voltage-gated potassium channel activity |
G | 0005515 | molecular_function | protein binding |
G | 0005737 | cellular_component | cytoplasm |
G | 0005829 | cellular_component | cytosol |
G | 0005856 | cellular_component | cytoskeleton |
G | 0005874 | cellular_component | microtubule |
G | 0005886 | cellular_component | plasma membrane |
G | 0006813 | biological_process | potassium ion transport |
G | 0008076 | cellular_component | voltage-gated potassium channel complex |
G | 0009898 | cellular_component | cytoplasmic side of plasma membrane |
G | 0014069 | cellular_component | postsynaptic density |
G | 0015459 | molecular_function | potassium channel regulator activity |
G | 0016020 | cellular_component | membrane |
G | 0016491 | molecular_function | oxidoreductase activity |
G | 0030424 | cellular_component | axon |
G | 0034705 | cellular_component | potassium channel complex |
G | 0043005 | cellular_component | neuron projection |
G | 0043194 | cellular_component | axon initial segment |
G | 0043679 | cellular_component | axon terminus |
G | 0044224 | cellular_component | juxtaparanode region of axon |
G | 0044325 | molecular_function | transmembrane transporter binding |
G | 0044877 | molecular_function | protein-containing complex binding |
G | 0045202 | cellular_component | synapse |
G | 0045445 | biological_process | myoblast differentiation |
G | 0050905 | biological_process | neuromuscular process |
G | 0055085 | biological_process | transmembrane transport |
G | 0055114 | biological_process | obsolete oxidation-reduction process |
G | 0070995 | biological_process | NADPH oxidation |
G | 0071805 | biological_process | potassium ion transmembrane transport |
G | 0098839 | cellular_component | postsynaptic density membrane |
G | 0098900 | biological_process | regulation of action potential |
G | 0098978 | cellular_component | glutamatergic synapse |
G | 1901379 | biological_process | regulation of potassium ion transmembrane transport |
G | 1990002 | molecular_function | methylglyoxal reductase (NADPH) (acetol producing) activity |
G | 1990031 | cellular_component | pinceau fiber |
G | 2000008 | biological_process | regulation of protein localization to cell surface |
H | 0005216 | molecular_function | monoatomic ion channel activity |
H | 0005249 | molecular_function | voltage-gated potassium channel activity |
H | 0006811 | biological_process | monoatomic ion transport |
H | 0006813 | biological_process | potassium ion transport |
H | 0008076 | cellular_component | voltage-gated potassium channel complex |
H | 0016020 | cellular_component | membrane |
H | 0051260 | biological_process | protein homooligomerization |
H | 0055085 | biological_process | transmembrane transport |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | ACT_SITE: Proton donor/acceptor => ECO:0000305|PubMed:18672894 |
Chain | Residue | Details |
A | TYR90 | |
G | TYR90 |
site_id | SWS_FT_FI2 |
Number of Residues | 28 |
Details | BINDING: BINDING => ECO:0000269|PubMed:10399921, ECO:0000269|PubMed:10884227, ECO:0000269|PubMed:16002581, ECO:0000269|PubMed:18004376, ECO:0000269|PubMed:18806782, ECO:0000269|PubMed:20360102, ECO:0000269|PubMed:20534430, ECO:0000269|PubMed:23705070, ECO:0007744|PDB:1EXB, ECO:0007744|PDB:1QRQ, ECO:0007744|PDB:2A79, ECO:0007744|PDB:2R9R, ECO:0007744|PDB:3EAU, ECO:0007744|PDB:3EB3, ECO:0007744|PDB:3EB4, ECO:0007744|PDB:3LNM, ECO:0007744|PDB:3LUT, ECO:0007744|PDB:4JTA, ECO:0007744|PDB:4JTC, ECO:0007744|PDB:4JTD |
Chain | Residue | Details |
A | THR56 | |
A | LYS254 | |
A | ARG264 | |
A | SER325 | |
A | GLN329 | |
A | ASN333 | |
G | THR56 | |
G | TRP57 | |
G | GLN63 | |
G | ASP85 | |
G | SER188 | |
A | TRP57 | |
G | GLN214 | |
G | TRP243 | |
G | SER244 | |
G | LEU246 | |
G | LYS254 | |
G | ARG264 | |
G | SER325 | |
G | GLN329 | |
G | ASN333 | |
A | GLN63 | |
A | ASP85 | |
A | SER188 | |
A | GLN214 | |
A | TRP243 | |
A | SER244 | |
A | LEU246 |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:18004376, ECO:0000269|PubMed:20360102, ECO:0000269|PubMed:23705070, ECO:0007744|PDB:2R9R, ECO:0007744|PDB:3LNM, ECO:0007744|PDB:4JTA |
Chain | Residue | Details |
A | ASN158 | |
G | ASN158 |
site_id | SWS_FT_FI4 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:10399921, ECO:0000269|PubMed:10884227, ECO:0000269|PubMed:16002581, ECO:0000269|PubMed:18004376, ECO:0000269|PubMed:18806782, ECO:0000269|PubMed:20360102, ECO:0000269|PubMed:20534430, ECO:0000269|PubMed:23705070, ECO:0007744|PDB:1EXB, ECO:0007744|PDB:1QRQ, ECO:0007744|PDB:2A79, ECO:0007744|PDB:2R9R, ECO:0007744|PDB:3EB3, ECO:0007744|PDB:3LNM, ECO:0007744|PDB:3LUT, ECO:0007744|PDB:4JTA, ECO:0007744|PDB:4JTC, ECO:0007744|PDB:4JTD |
Chain | Residue | Details |
A | ARG189 | |
G | ARG189 |
site_id | SWS_FT_FI5 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:10399921, ECO:0000269|PubMed:10884227, ECO:0000269|PubMed:16002581, ECO:0000269|PubMed:18004376, ECO:0000269|PubMed:18806782, ECO:0000269|PubMed:20360102, ECO:0000269|PubMed:20534430, ECO:0000269|PubMed:23705070, ECO:0007744|PDB:1EXB, ECO:0007744|PDB:1QRQ, ECO:0007744|PDB:2R9R, ECO:0007744|PDB:3EAU, ECO:0007744|PDB:3EB3, ECO:0007744|PDB:3EB4, ECO:0007744|PDB:3LNM, ECO:0007744|PDB:3LUT, ECO:0007744|PDB:4JTA, ECO:0007744|PDB:4JTC, ECO:0007744|PDB:4JTD |
Chain | Residue | Details |
A | PRO245 | |
G | PRO245 |
site_id | SWS_FT_FI6 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:10399921, ECO:0000269|PubMed:10884227, ECO:0000269|PubMed:18004376, ECO:0000269|PubMed:18806782, ECO:0000269|PubMed:20360102, ECO:0000269|PubMed:23705070, ECO:0007744|PDB:1EXB, ECO:0007744|PDB:1QRQ, ECO:0007744|PDB:2R9R, ECO:0007744|PDB:3EAU, ECO:0007744|PDB:3EB3, ECO:0007744|PDB:3EB4, ECO:0007744|PDB:3LNM, ECO:0007744|PDB:4JTA |
Chain | Residue | Details |
A | ALA247 | |
G | ALA247 |
site_id | SWS_FT_FI7 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:10399921, ECO:0000269|PubMed:10884227, ECO:0000269|PubMed:16002581, ECO:0000269|PubMed:18004376, ECO:0000269|PubMed:18806782, ECO:0000269|PubMed:20360102, ECO:0000269|PubMed:20534430, ECO:0000269|PubMed:23705070, ECO:0007744|PDB:1EXB, ECO:0007744|PDB:1QRQ, ECO:0007744|PDB:2A79, ECO:0007744|PDB:2R9R, ECO:0007744|PDB:3EAU, ECO:0007744|PDB:3EB3, ECO:0007744|PDB:3EB4, ECO:0007744|PDB:3LNM, ECO:0007744|PDB:3LUT, ECO:0007744|PDB:4JTA, ECO:0007744|PDB:4JTD |
Chain | Residue | Details |
A | CYS248 | |
G | CYS248 |
site_id | SWS_FT_FI8 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:10399921, ECO:0000269|PubMed:23705070, ECO:0007744|PDB:1QRQ, ECO:0007744|PDB:4JTC, ECO:0007744|PDB:4JTD |
Chain | Residue | Details |
A | TYR262 | |
G | TYR262 |
site_id | SWS_FT_FI9 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:23705070, ECO:0007744|PDB:4JTC, ECO:0007744|PDB:4JTD |
Chain | Residue | Details |
A | GLY323 | |
G | GLY323 |
site_id | SWS_FT_FI10 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:10399921, ECO:0000269|PubMed:10884227, ECO:0000269|PubMed:16002581, ECO:0000269|PubMed:18004376, ECO:0000269|PubMed:20360102, ECO:0000269|PubMed:20534430, ECO:0000269|PubMed:23705070, ECO:0007744|PDB:1EXB, ECO:0007744|PDB:1QRQ, ECO:0007744|PDB:2A79, ECO:0007744|PDB:2R9R, ECO:0007744|PDB:3LNM, ECO:0007744|PDB:3LUT, ECO:0007744|PDB:4JTA, ECO:0007744|PDB:4JTC, ECO:0007744|PDB:4JTD |
Chain | Residue | Details |
A | GLU332 | |
G | GLU332 |
site_id | SWS_FT_FI11 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:21357749 |
Chain | Residue | Details |
A | SER112 | |
G | SER112 |
site_id | SWS_FT_FI12 |
Number of Residues | 2 |
Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q13303 |
Chain | Residue | Details |
A | LYS124 | |
G | LYS124 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 2alr |
Chain | Residue | Details |
A | TYR90 | |
A | LYS118 |
site_id | CSA2 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 2alr |
Chain | Residue | Details |
G | TYR90 | |
G | LYS118 |