2O07
Human spermidine synthase
GO（遺伝子オントロジー）由来の情報
| 鎖名 | GO（遺伝子オントロジー）id | 名前空間 | 内容 |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004766 | molecular_function | spermidine synthase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005829 | cellular_component | cytosol |
| A | 0006595 | biological_process | polyamine metabolic process |
| A | 0006596 | biological_process | polyamine biosynthetic process |
| A | 0008295 | biological_process | spermidine biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 1990830 | biological_process | cellular response to leukemia inhibitory factor |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004766 | molecular_function | spermidine synthase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005829 | cellular_component | cytosol |
| B | 0006595 | biological_process | polyamine metabolic process |
| B | 0006596 | biological_process | polyamine biosynthetic process |
| B | 0008295 | biological_process | spermidine biosynthetic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0042803 | molecular_function | protein homodimerization activity |
| B | 1990830 | biological_process | cellular response to leukemia inhibitory factor |
PDBデータベースに由来する情報
| site_id | AC1 |
| 残基数 | 12 |
| 詳細 | BINDING SITE FOR RESIDUE SPD A 601 |
| 鎖名 | 残基 |
| A | GLU23 |
| A | TYR241 |
| A | PRO242 |
| A | MTA501 |
| A | VAL68 |
| A | ILE69 |
| A | GLN70 |
| A | TYR79 |
| A | GLN80 |
| A | ASP104 |
| A | ASP173 |
| A | SER174 |
| site_id | AC2 |
| 残基数 | 13 |
| 詳細 | BINDING SITE FOR RESIDUE SPD B 601 |
| 鎖名 | 残基 |
| B | TRP28 |
| B | VAL68 |
| B | GLN70 |
| B | TYR79 |
| B | GLN80 |
| B | ASP104 |
| B | ASP173 |
| B | SER174 |
| B | ASP176 |
| B | TYR241 |
| B | MTA501 |
| B | HOH603 |
| B | HOH605 |
| site_id | AC3 |
| 残基数 | 15 |
| 詳細 | BINDING SITE FOR RESIDUE MTA A 501 |
| 鎖名 | 残基 |
| A | GLN49 |
| A | LEU65 |
| A | GLY101 |
| A | GLY103 |
| A | ASP104 |
| A | CYS123 |
| A | GLU124 |
| A | ILE125 |
| A | VAL129 |
| A | GLY154 |
| A | ASP155 |
| A | GLY156 |
| A | ASP173 |
| A | SER175 |
| A | SPD601 |
| site_id | AC4 |
| 残基数 | 18 |
| 詳細 | BINDING SITE FOR RESIDUE MTA B 501 |
| 鎖名 | 残基 |
| B | GLN49 |
| B | LEU65 |
| B | GLY101 |
| B | GLY103 |
| B | ASP104 |
| B | CYS123 |
| B | GLU124 |
| B | ILE125 |
| B | ASP126 |
| B | VAL129 |
| B | GLY154 |
| B | ASP155 |
| B | GLY156 |
| B | ASP173 |
| B | PRO180 |
| B | ALA181 |
| B | SER183 |
| B | SPD601 |
UniProtにおけるモチーフ・データベースPROSITEからの機能情報
| site_id | PS01330 |
| 残基数 | 14 |
| 詳細 | PABS_1 Polyamine biosynthesis (PABS) domain signature. VLIIGGGdGgvLrE |
| 鎖名 | 残基 | 詳細 |
| A | VAL97-GLU110 |
SwissProt/UniProtに記載されている蛋白質分子機能情報
| site_id | SWS_FT_FI1 |
| 残基数 | 2 |
| 詳細 | ACT_SITE: Proton acceptor => ECO:0000250 |
| 鎖名 | 残基 | 詳細 |
| A | ASP173 | |
| B | ASP173 |
| site_id | SWS_FT_FI2 |
| 残基数 | 16 |
| 詳細 | BINDING: |
| 鎖名 | 残基 | 詳細 |
| A | GLN49 | |
| B | TYR79 | |
| B | GLN80 | |
| B | ASP104 | |
| B | GLU124 | |
| B | ASP155 | |
| B | ASP173 | |
| B | TYR241 | |
| A | TYR79 | |
| A | GLN80 | |
| A | ASP104 | |
| A | GLU124 | |
| A | ASP155 | |
| A | ASP173 | |
| A | TYR241 | |
| B | GLN49 |
| site_id | SWS_FT_FI3 |
| 残基数 | 2 |
| 詳細 | MOD_RES: N-acetylmethionine => ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378 |
| 鎖名 | 残基 | 詳細 |
| A | MET1 | |
| B | MET1 |
