Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003723 | molecular_function | RNA binding |
| A | 0003743 | molecular_function | translation initiation factor activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006413 | biological_process | translational initiation |
| B | 0008190 | molecular_function | eukaryotic initiation factor 4E binding |
| B | 0045947 | biological_process | negative regulation of translational initiation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE MGT B1000 |
| Chain | Residue |
| A | ARG67 |
| A | HOH2018 |
| B | HOH2028 |
| B | HOH2029 |
| B | HOH2030 |
| B | HOH2031 |
| B | HOH2032 |
| B | HOH2033 |
| A | THR73 |
| A | TYR78 |
| A | HIS110 |
| A | MET123 |
| A | TRP124 |
| A | GLU125 |
| A | ARG174 |
| A | PHE234 |
Functional Information from PROSITE/UniProt
| site_id | PS00813 |
| Number of Residues | 24 |
| Details | IF4E Eukaryotic initiation factor 4E signature. DFhlFKegIkPmWEDdanknGGKW |
| Chain | Residue | Details |
| A | ASP112-TRP135 | |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| B | ARG51 | |
| A | LYS222 | |
| Chain | Residue | Details |
| B | ASP55 | |
| A | TRP124 | |
| A | ARG174 | |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by DYRK2, MAPK1, MAPK3 and MTOR => ECO:0000269|PubMed:12588975, ECO:0000269|PubMed:12747827, ECO:0000269|PubMed:22578813, ECO:0000269|PubMed:25702871, ECO:0000269|PubMed:29750193, ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| B | PRO66 | |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:22578813 |
| Chain | Residue | Details |
| B | PHE58 | |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ISG15) => ECO:0000269|PubMed:17289916 |
| Chain | Residue | Details |
| A | LYS222 | |
