2D1J

Factor Xa in complex with the inhibitor 2-[[4-[(5-chloroindol-2-yl)sulfonyl]piperazin-1-yl] carbonyl]thieno[3,2-b]pyridine n-oxide

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Functional Information from GO Data

ChainGOidnamespacecontents
A0005788cellular_componentendoplasmic reticulum lumen
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005796cellular_componentGolgi lumen
A0031233cellular_componentintrinsic component of external side of plasma membrane
A0005886cellular_componentplasma membrane
A0005509molecular_functioncalcium ion binding
A0005543molecular_functionphospholipid binding
A0004252molecular_functionserine-type endopeptidase activity
A0007596biological_processblood coagulation
A0007598biological_processblood coagulation, extrinsic pathway
A0006888biological_processER to Golgi vesicle-mediated transport
A0030335biological_processpositive regulation of cell migration
A0051897biological_processpositive regulation of protein kinase B signaling
B0005788cellular_componentendoplasmic reticulum lumen
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005796cellular_componentGolgi lumen
B0031233cellular_componentintrinsic component of external side of plasma membrane
B0005886cellular_componentplasma membrane
B0005509molecular_functioncalcium ion binding
B0005543molecular_functionphospholipid binding
B0004252molecular_functionserine-type endopeptidase activity
B0007596biological_processblood coagulation
B0007598biological_processblood coagulation, extrinsic pathway
B0006888biological_processER to Golgi vesicle-mediated transport
B0030335biological_processpositive regulation of cell migration
B0051897biological_processpositive regulation of protein kinase B signaling
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Functional Information from PDB Data

site_idNumber of ResiduesDetails
AC16BINDING SITE FOR RESIDUE CA A 261
ChainResidue
AASP70
AASN72
AGLN75
AGLU80
AHOH342
AHOH353

AC25BINDING SITE FOR RESIDUE CA A 262
ChainResidue
ATYR185
AASP185
AARG222
ALYS224
AHOH388

AC315BINDING SITE FOR RESIDUE D01 A 700
ChainResidue
AGLU97
ATYR99
APHE174
AASP189
AALA190
AGLN192
AVAL213
ATRP215
AGLY216
AGLU217
AGLY218
ACYS220
AGLY226
AILE227
ATYR228

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Functional Information from PDB atom coordinates for the "HETATM" binding sites

site_idNumber of ResiduesDetails
?

Functional Information from PROSITE/UniProt

site_idNumber of ResiduesDetails
PS0013512Serine proteases, trypsin family, serine active site.[DNSTAGC]-[GSTAPIMVQH]-x(2)-G-[DE]-S-G-[GS]-[SAPHV]-[LIVMFYWH]-[LIVMFYSTANQH].
ChainResidueDetails
AASP189-VAL200

PS0118616EGF-like domain signature 2.C-x-C-x(2)-[GP]-[FYW]-x(4,8)-C.
ChainResidueDetails
BCYS109-CYS124

PS001346Serine proteases, trypsin family, histidine active site.[LIVM]-[ST]-A-[STAG]-H-C.
ChainResidueDetails
ALEU53-CYS58

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Functional Information from SwissProt/UniProt

site_idNumber of ResiduesDetails
SWS_FT_FI13Charge relay system.
ChainResidueDetails
AHIS42
AASP88
ASER185

SWS_FT_FI23Charge relay system.
ChainResidueDetails
BNA*
BNA*
BNA*

CSA12Annotated By Reference To The Literature 1a0j
ChainResidueDetails
AASP102
AHIS57

CSA22Annotated By Reference To The Literature 1a0j
ChainResidueDetails
ASER195
AGLY196

CSA32Annotated By Reference To The Literature 1a0j
ChainResidueDetails
ASER195
AGLY193

CSA43Annotated By Reference To The Literature 1a0j
ChainResidueDetails
AASP102
ASER195
AHIS57

CSA54Annotated By Reference To The Literature 1a0j
ChainResidueDetails
ASER195
AASP100
AGLY193
AHIS57

CSA64Annotated By Reference To The Literature 1a0j
ChainResidueDetails
AASP102
ASER195
AHIS57
AGLY196

CSA74Annotated By Reference To The Literature 1a0j
ChainResidueDetails
AASP102
ASER195
AGLY193
AHIS57

?

Catalytic Information from CSA

site_idNumber of ResiduesDetails
CSA12Annotated By Reference To The Literature 1a0j
ChainResidueDetails
AASP102
AHIS57

CSA22Annotated By Reference To The Literature 1a0j
ChainResidueDetails
ASER195
AGLY196

CSA32Annotated By Reference To The Literature 1a0j
ChainResidueDetails
ASER195
AGLY193

CSA43Annotated By Reference To The Literature 1a0j
ChainResidueDetails
AASP102
ASER195
AHIS57

CSA54Annotated By Reference To The Literature 1a0j
ChainResidueDetails
ASER195
AASP100
AGLY193
AHIS57

CSA64Annotated By Reference To The Literature 1a0j
ChainResidueDetails
AASP102
ASER195
AHIS57
AGLY196

CSA74Annotated By Reference To The Literature 1a0j
ChainResidueDetails
AASP102
ASER195
AGLY193
AHIS57

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건을2020-07-15부터공개중