2CAG

CATALASE COMPOUND II

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004096	molecular_function	catalase activity
A	0004601	molecular_function	peroxidase activity
A	0005737	cellular_component	cytoplasm
A	0006979	biological_process	response to oxidative stress
A	0020037	molecular_function	heme binding
A	0042542	biological_process	response to hydrogen peroxide
A	0042744	biological_process	hydrogen peroxide catabolic process
A	0046872	molecular_function	metal ion binding
A	0098869	biological_process	cellular oxidant detoxification

Functional Information from PDB Data

site_id	AC1
Number of Residues	20
Details	BINDING SITE FOR RESIDUE HEM A 485

Chain	Residue
A	ASN127
A	PRO137
A	PHE140
A	GLY195
A	SER196
A	PHE313
A	ARG333
A	SER336
A	TYR337
A	HIS341
A	ARG344
A	HOH553
A	HOH555
A	ASP44
A	ARG51
A	HIS54
A	ARG91
A	GLY110
A	VAL125
A	GLY126

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site_id	DH
Number of Residues	1
Details	DISTAL HISTIDINE.

Chain	Residue
A	HIS54

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site_id	PT
Number of Residues	1
Details	PROXIMAL TYROSINE.

Chain	Residue
A	TYR337

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Functional Information from PROSITE/UniProt

site_id	PS00437
Number of Residues	9
Details	CATALASE_1 Catalase proximal heme-ligand signature. RLFSYgDAH

Chain	Residue	Details
A	ARG333-HIS341

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site_id	PS00438
Number of Residues	17
Details	CATALASE_2 Catalase proximal active site signature. FdRevipERrmHakGSG

Chain	Residue	Details
A	PHE43-GLY59

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE:

Chain	Residue	Details
A	HIS54
A	ASN127

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site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING: axial binding residue => ECO:0000269|PubMed:7791219

Chain	Residue	Details
A	TYR337

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Methionine sulfone => ECO:0000269|PubMed:7786407

Chain	Residue	Details
A	OMT53

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1iph

Chain	Residue	Details
A	HIS54
A	ASN127
A	SER93

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