1TGV
Structure of E. coli Uridine Phosphorylase complexed with 5-Fluorouridine and sulfate
GO（遺伝子オントロジー）由来の情報
| 鎖名 | GO（遺伝子オントロジー）id | 名前空間 | 内容 |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004850 | molecular_function | uridine phosphorylase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006218 | biological_process | uridine catabolic process |
| A | 0006974 | biological_process | DNA damage response |
| A | 0009116 | biological_process | nucleoside metabolic process |
| A | 0009164 | biological_process | nucleoside catabolic process |
| A | 0009166 | biological_process | nucleotide catabolic process |
| A | 0016757 | molecular_function | glycosyltransferase activity |
| A | 0016763 | molecular_function | pentosyltransferase activity |
| A | 0030955 | molecular_function | potassium ion binding |
| A | 0032991 | cellular_component | protein-containing complex |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0044206 | biological_process | UMP salvage |
| A | 0046050 | biological_process | UMP catabolic process |
| A | 0047847 | molecular_function | deoxyuridine phosphorylase activity |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004850 | molecular_function | uridine phosphorylase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006218 | biological_process | uridine catabolic process |
| B | 0006974 | biological_process | DNA damage response |
| B | 0009116 | biological_process | nucleoside metabolic process |
| B | 0009164 | biological_process | nucleoside catabolic process |
| B | 0009166 | biological_process | nucleotide catabolic process |
| B | 0016757 | molecular_function | glycosyltransferase activity |
| B | 0016763 | molecular_function | pentosyltransferase activity |
| B | 0030955 | molecular_function | potassium ion binding |
| B | 0032991 | cellular_component | protein-containing complex |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0044206 | biological_process | UMP salvage |
| B | 0046050 | biological_process | UMP catabolic process |
| B | 0047847 | molecular_function | deoxyuridine phosphorylase activity |
PDBデータベースに由来する情報
| site_id | AC1 |
| 残基数 | 8 |
| 詳細 | BINDING SITE FOR RESIDUE SO4 A 482 |
| 鎖名 | 残基 |
| A | GLY26 |
| A | ARG30 |
| A | ARG91 |
| A | ILE92 |
| A | GLY93 |
| A | THR94 |
| A | 5UD3001 |
| B | ARG48 |
| site_id | AC2 |
| 残基数 | 8 |
| 詳細 | BINDING SITE FOR RESIDUE SO4 B 682 |
| 鎖名 | 残基 |
| B | GLY26 |
| B | ARG30 |
| B | ARG91 |
| B | ILE92 |
| B | GLY93 |
| B | THR94 |
| B | 5UD5002 |
| A | ARG48 |
| site_id | AC3 |
| 残基数 | 6 |
| 詳細 | BINDING SITE FOR RESIDUE K A 1001 |
| 鎖名 | 残基 |
| A | GLU49 |
| A | ILE69 |
| A | SER73 |
| B | GLU49 |
| B | ILE69 |
| B | SER73 |
| site_id | AC4 |
| 残基数 | 17 |
| 詳細 | BINDING SITE FOR RESIDUE 5UD A 3001 |
| 鎖名 | 残基 |
| A | ARG91 |
| A | THR94 |
| A | THR95 |
| A | GLY96 |
| A | PHE162 |
| A | GLN166 |
| A | ARG168 |
| A | GLU196 |
| A | MET197 |
| A | GLU198 |
| A | ILE220 |
| A | VAL221 |
| A | SO4482 |
| A | HOH3032 |
| A | HOH3035 |
| B | PHE7 |
| B | HIS8 |
| site_id | AC5 |
| 残基数 | 17 |
| 詳細 | BINDING SITE FOR RESIDUE 5UD B 5002 |
| 鎖名 | 残基 |
| A | HIS8 |
| B | ILE69 |
| B | ARG91 |
| B | THR94 |
| B | THR95 |
| B | GLY96 |
| B | PHE162 |
| B | GLN166 |
| B | ARG168 |
| B | GLU196 |
| B | MET197 |
| B | GLU198 |
| B | ILE220 |
| B | VAL221 |
| B | SO4682 |
| B | HOH5020 |
| B | HOH5084 |
UniProtにおけるモチーフ・データベースPROSITEからの機能情報
| site_id | PS01232 |
| 残基数 | 16 |
| 詳細 | PNP_UDP_1 Purine and other phosphorylases family 1 signature. StGIGgPStSIaveEL |
| 鎖名 | 残基 | 詳細 |
| A | SER66-LEU81 |
CSAにおける酵素触媒機能の情報
| site_id | CSA1 |
| 残基数 | 3 |
| 詳細 | Annotated By Reference To The Literature 1t0u |
| 鎖名 | 残基 | 詳細 |
| A | GLU80 | |
| A | HIS8 | |
| A | ARG223 |
| site_id | CSA2 |
| 残基数 | 3 |
| 詳細 | Annotated By Reference To The Literature 1t0u |
| 鎖名 | 残基 | 詳細 |
| B | GLU80 | |
| B | HIS8 | |
| B | ARG223 |
| site_id | MCSA1 |
| 残基数 | 4 |
| 詳細 | M-CSA 787 |
| 鎖名 | 残基 | 詳細 |
| A | HIS8 | proton acceptor, proton donor |
| A | GLU80 | electrostatic stabiliser, polar interaction |
| A | ARG168 | proton acceptor, proton donor |
| A | ARG223 | electrostatic stabiliser, polar interaction |
| site_id | MCSA2 |
| 残基数 | 4 |
| 詳細 | M-CSA 787 |
| 鎖名 | 残基 | 詳細 |
| B | HIS8 | proton acceptor, proton donor |
| B | GLU80 | electrostatic stabiliser, polar interaction |
| B | ARG168 | proton acceptor, proton donor |
| B | ARG223 | electrostatic stabiliser, polar interaction |
