1QIP
HUMAN GLYOXALASE I COMPLEXED WITH S-P-NITROBENZYLOXYCARBONYLGLUTATHIONE
GO（遺伝子オントロジー）由来の情報
| 鎖名 | GO（遺伝子オントロジー）id | 名前空間 | 内容 |
| A | 0004462 | molecular_function | lactoylglutathione lyase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0005975 | biological_process | carbohydrate metabolic process |
| A | 0006357 | biological_process | regulation of transcription by RNA polymerase II |
| A | 0006749 | biological_process | glutathione metabolic process |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0009438 | biological_process | methylglyoxal metabolic process |
| A | 0016829 | molecular_function | lyase activity |
| A | 0030316 | biological_process | osteoclast differentiation |
| A | 0043066 | biological_process | negative regulation of apoptotic process |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0070062 | cellular_component | extracellular exosome |
| B | 0004462 | molecular_function | lactoylglutathione lyase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005654 | cellular_component | nucleoplasm |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0005975 | biological_process | carbohydrate metabolic process |
| B | 0006357 | biological_process | regulation of transcription by RNA polymerase II |
| B | 0006749 | biological_process | glutathione metabolic process |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0009438 | biological_process | methylglyoxal metabolic process |
| B | 0016829 | molecular_function | lyase activity |
| B | 0030316 | biological_process | osteoclast differentiation |
| B | 0043066 | biological_process | negative regulation of apoptotic process |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0070062 | cellular_component | extracellular exosome |
| C | 0004462 | molecular_function | lactoylglutathione lyase activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005654 | cellular_component | nucleoplasm |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0005975 | biological_process | carbohydrate metabolic process |
| C | 0006357 | biological_process | regulation of transcription by RNA polymerase II |
| C | 0006749 | biological_process | glutathione metabolic process |
| C | 0008270 | molecular_function | zinc ion binding |
| C | 0009438 | biological_process | methylglyoxal metabolic process |
| C | 0016829 | molecular_function | lyase activity |
| C | 0030316 | biological_process | osteoclast differentiation |
| C | 0043066 | biological_process | negative regulation of apoptotic process |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0070062 | cellular_component | extracellular exosome |
| D | 0004462 | molecular_function | lactoylglutathione lyase activity |
| D | 0005515 | molecular_function | protein binding |
| D | 0005654 | cellular_component | nucleoplasm |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0005886 | cellular_component | plasma membrane |
| D | 0005975 | biological_process | carbohydrate metabolic process |
| D | 0006357 | biological_process | regulation of transcription by RNA polymerase II |
| D | 0006749 | biological_process | glutathione metabolic process |
| D | 0008270 | molecular_function | zinc ion binding |
| D | 0009438 | biological_process | methylglyoxal metabolic process |
| D | 0016829 | molecular_function | lyase activity |
| D | 0030316 | biological_process | osteoclast differentiation |
| D | 0043066 | biological_process | negative regulation of apoptotic process |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0070062 | cellular_component | extracellular exosome |
PDBデータベースに由来する情報
| site_id | AC1 |
| 残基数 | 6 |
| 詳細 | BINDING SITE FOR RESIDUE ZN B 901 |
| 鎖名 | 残基 |
| A | HIS126 |
| A | GLU172 |
| A | HOH1227 |
| A | HOH1228 |
| B | GLN33 |
| B | GLU99 |
| site_id | AC2 |
| 残基数 | 6 |
| 詳細 | BINDING SITE FOR RESIDUE ZN A 902 |
| 鎖名 | 残基 |
| B | HOH1225 |
| A | GLN33 |
| A | GLU99 |
| A | HOH1229 |
| B | HIS126 |
| B | GLU172 |
| site_id | AC3 |
| 残基数 | 6 |
| 詳細 | BINDING SITE FOR RESIDUE ZN D 903 |
| 鎖名 | 残基 |
| C | HIS126 |
| C | GLU172 |
| C | HOH1232 |
| D | GLN33 |
| D | GLU99 |
| D | HOH1227 |
| site_id | AC4 |
| 残基数 | 6 |
| 詳細 | BINDING SITE FOR RESIDUE ZN C 904 |
| 鎖名 | 残基 |
| C | GLN33 |
| C | GLU99 |
| C | HOH1233 |
| D | HIS126 |
| D | GLU172 |
| D | HOH1228 |
| site_id | AC5 |
| 残基数 | 25 |
| 詳細 | BINDING SITE FOR RESIDUE GNB B 1001 |
| 鎖名 | 残基 |
| A | ARG122 |
| A | LEU160 |
| A | PHE162 |
| A | GLU172 |
| A | MET179 |
| A | LEU182 |
| A | HOH1227 |
| B | ARG37 |
| B | CYS60 |
| B | PHE67 |
| B | ILE88 |
| B | LEU92 |
| B | THR101 |
| B | ASN103 |
| B | BME204 |
| B | HOH1006 |
| B | HOH1040 |
| B | HOH1100 |
| B | HOH1102 |
| B | HOH1107 |
| B | HOH1113 |
| B | HOH1125 |
| B | HOH1129 |
| B | HOH1197 |
| C | SER17 |
| site_id | AC6 |
| 残基数 | 22 |
| 詳細 | BINDING SITE FOR RESIDUE GNB A 1002 |
| 鎖名 | 残基 |
| A | ARG37 |
| A | GLN58 |
| A | CYS60 |
| A | PHE67 |
| A | PHE71 |
| A | ILE88 |
| A | LEU92 |
| A | THR101 |
| A | ASN103 |
| A | BME204 |
| A | HOH1037 |
| A | HOH1112 |
| A | HOH1138 |
| A | HOH1178 |
| B | ARG122 |
| B | MET157 |
| B | LEU160 |
| B | PHE162 |
| B | TRP170 |
| D | ASP154 |
| D | LYS158 |
| D | HOH1005 |
| site_id | AC7 |
| 残基数 | 25 |
| 詳細 | BINDING SITE FOR RESIDUE GNB D 1003 |
| 鎖名 | 残基 |
| A | SER17 |
| A | HOH1116 |
| C | ARG122 |
| C | MET157 |
| C | LEU160 |
| C | PHE162 |
| C | MET179 |
| C | HOH1061 |
| D | ARG37 |
| D | CYS60 |
| D | PHE67 |
| D | ILE88 |
| D | LEU92 |
| D | THR101 |
| D | ASN103 |
| D | BME204 |
| D | HOH1049 |
| D | HOH1104 |
| D | HOH1105 |
| D | HOH1109 |
| D | HOH1114 |
| D | HOH1117 |
| D | HOH1125 |
| D | HOH1128 |
| D | HOH1194 |
| site_id | AC8 |
| 残基数 | 22 |
| 詳細 | BINDING SITE FOR RESIDUE GNB C 1004 |
| 鎖名 | 残基 |
| C | ARG37 |
| C | CYS60 |
| C | PHE67 |
| C | ILE88 |
| C | LEU92 |
| C | THR101 |
| C | ASN103 |
| C | BME204 |
| C | HOH1005 |
| C | HOH1038 |
| C | HOH1092 |
| C | HOH1109 |
| C | HOH1113 |
| C | HOH1165 |
| C | HOH1171 |
| C | HOH1186 |
| C | HOH1225 |
| D | ARG122 |
| D | MET157 |
| D | LEU160 |
| D | PHE162 |
| D | MET179 |
| site_id | AC9 |
| 残基数 | 5 |
| 詳細 | BINDING SITE FOR RESIDUE BME A 204 |
| 鎖名 | 残基 |
| A | GLN58 |
| A | LYS59 |
| A | CYS60 |
| A | PHE62 |
| A | GNB1002 |
| site_id | BC1 |
| 残基数 | 6 |
| 詳細 | BINDING SITE FOR RESIDUE BME B 204 |
| 鎖名 | 残基 |
| B | GLN58 |
| B | LYS59 |
| B | CYS60 |
| B | LYS84 |
| B | GNB1001 |
| B | HOH1222 |
| site_id | BC2 |
| 残基数 | 3 |
| 詳細 | BINDING SITE FOR RESIDUE BME C 204 |
| 鎖名 | 残基 |
| C | GLN58 |
| C | CYS60 |
| C | GNB1004 |
| site_id | BC3 |
| 残基数 | 3 |
| 詳細 | BINDING SITE FOR RESIDUE BME D 204 |
| 鎖名 | 残基 |
| D | CYS60 |
| D | PHE62 |
| D | GNB1003 |
| site_id | GH1 |
| 残基数 | 3 |
| 詳細 | BINDING SITE FOR GSH MOIETY - SUBSTRATE BINDING SITE IS FORMED BY ZN2 HYD2 AND GSH2. |
| 鎖名 | 残基 |
| A | ARG37 |
| A | ASN103 |
| B | ARG122 |
| site_id | GH2 |
| 残基数 | 3 |
| 詳細 | BINDING SITE FOR GSH MOIETY - SUBSTRATE BINDING SITE IS FORMED BY ZN1 HYD1 AND GSH1. |
| 鎖名 | 残基 |
| B | ARG37 |
| B | ASN103 |
| A | ARG122 |
| site_id | GH3 |
| 残基数 | 3 |
| 詳細 | BINDING SITE FOR GSH MOIETY - SUBSTRATE BINDING SITE IS FORMED BY ZN2 HYD2 AND GSH2. |
| 鎖名 | 残基 |
| C | ARG37 |
| C | ASN103 |
| D | ARG122 |
| site_id | GH4 |
| 残基数 | 3 |
| 詳細 | BINDING SITE FOR GSH MOIETY - SUBSTRATE BINDING SITE IS FORMED BY ZN1 HYD1 AND GSH1. |
| 鎖名 | 残基 |
| D | ARG37 |
| D | ASN103 |
| C | ARG122 |
| site_id | HD2 |
| 残基数 | 14 |
| 詳細 | HYDROPHOBIC SUBSTRATE BINDING POCKET AT DIMER INTERFACE. |
| 鎖名 | 残基 |
| A | CYS60 |
| A | PHE62 |
| A | MET65 |
| A | PHE67 |
| A | LEU69 |
| A | PHE71 |
| A | ILE88 |
| A | LEU92 |
| B | MET157 |
| B | LEU160 |
| B | PHE162 |
| B | LEU174 |
| B | MET179 |
| B | MET183 |
| site_id | HD3 |
| 残基数 | 14 |
| 詳細 | HYDROPHOBIC SUBSTRATE BINDING POCKET AT DIMER INTERFACE. |
| 鎖名 | 残基 |
| B | CYS60 |
| B | PHE62 |
| B | MET65 |
| B | PHE67 |
| B | LEU69 |
| B | PHE71 |
| B | ILE88 |
| B | LEU92 |
| A | MET157 |
| A | LEU160 |
| A | PHE162 |
| A | LEU174 |
| A | MET179 |
| A | MET183 |
| site_id | HD4 |
| 残基数 | 14 |
| 詳細 | HYDROPHOBIC SUBSTRATE BINDING POCKET AT DIMER INTERFACE. |
| 鎖名 | 残基 |
| C | CYS60 |
| C | PHE62 |
| C | MET65 |
| C | PHE67 |
| C | LEU69 |
| C | PHE71 |
| C | ILE88 |
| C | LEU92 |
| D | MET157 |
| D | LEU160 |
| D | PHE162 |
| D | LEU174 |
| D | MET179 |
| D | MET183 |
| site_id | HD5 |
| 残基数 | 14 |
| 詳細 | HYDROPHOBIC SUBSTRATE BINDING POCKET AT DIMER INTERFACE. |
| 鎖名 | 残基 |
| D | CYS60 |
| D | PHE62 |
| D | MET65 |
| D | PHE67 |
| D | LEU69 |
| D | PHE71 |
| D | ILE88 |
| D | LEU92 |
| C | MET157 |
| C | LEU160 |
| C | PHE162 |
| C | LEU174 |
| C | MET179 |
| C | MET183 |
| site_id | ZN1 |
| 残基数 | 5 |
| 詳細 | ZINC BINDING SITE AT DIMER INTERFACE. |
| 鎖名 | 残基 |
| A | ZN902 |
| A | GLN33 |
| A | GLU99 |
| B | HIS126 |
| B | GLU172 |
| site_id | ZN2 |
| 残基数 | 5 |
| 詳細 | ZINC BINDING SITE AT DIMER INTERFACE. |
| 鎖名 | 残基 |
| A | GLU172 |
| B | ZN901 |
| B | GLN33 |
| B | GLU99 |
| A | HIS126 |
| site_id | ZN3 |
| 残基数 | 5 |
| 詳細 | ZINC BINDING SITE AT DIMER INTERFACE. |
| 鎖名 | 残基 |
| C | ZN904 |
| C | GLN33 |
| C | GLU99 |
| D | HIS126 |
| D | GLU172 |
| site_id | ZN4 |
| 残基数 | 5 |
| 詳細 | ZINC BINDING SITE AT DIMER INTERFACE. |
| 鎖名 | 残基 |
| D | ZN903 |
| D | GLN33 |
| D | GLU99 |
| C | HIS126 |
| C | GLU172 |
UniProtにおけるモチーフ・データベースPROSITEからの機能情報
SwissProt/UniProtに記載されている蛋白質分子機能情報
| site_id | SWS_FT_FI1 |
| 残基数 | 4 |
| 詳細 | ACT_SITE: Proton donor/acceptor => ECO:0000269|PubMed:10521255, ECO:0000269|PubMed:9705294 |
| 鎖名 | 残基 | 詳細 |
| A | ILE173 | |
| B | ILE173 | |
| C | ILE173 | |
| D | ILE173 |
| site_id | SWS_FT_FI2 |
| 残基数 | 8 |
| 詳細 | BINDING: BINDING => ECO:0000269|PubMed:23122816, ECO:0000269|PubMed:9218781, ECO:0000269|PubMed:9705294 |
| 鎖名 | 残基 | 詳細 |
| A | THR34 | |
| A | LEU100 | |
| B | THR34 | |
| B | LEU100 | |
| C | THR34 | |
| C | LEU100 | |
| D | THR34 | |
| D | LEU100 |
| site_id | SWS_FT_FI3 |
| 残基数 | 8 |
| 詳細 | BINDING: |
| 鎖名 | 残基 | 詳細 |
| A | VAL38 | |
| A | TRP104 | |
| B | VAL38 | |
| B | TRP104 | |
| C | VAL38 | |
| C | TRP104 | |
| D | VAL38 | |
| D | TRP104 |
| site_id | SWS_FT_FI4 |
| 残基数 | 8 |
| 詳細 | BINDING: in other chain |
| 鎖名 | 残基 | 詳細 |
| A | GLY123 | |
| A | MET157 | |
| B | GLY123 | |
| B | MET157 | |
| C | GLY123 | |
| C | MET157 | |
| D | GLY123 | |
| D | MET157 |
| site_id | SWS_FT_FI5 |
| 残基数 | 8 |
| 詳細 | BINDING: in other chain => ECO:0000269|PubMed:23122816, ECO:0000269|PubMed:9218781, ECO:0000269|PubMed:9705294 |
| 鎖名 | 残基 | 詳細 |
| A | ILE127 | |
| A | ILE173 | |
| B | ILE127 | |
| B | ILE173 | |
| C | ILE127 | |
| C | ILE173 | |
| D | ILE127 | |
| D | ILE173 |
| site_id | SWS_FT_FI6 |
| 残基数 | 4 |
| 詳細 | MOD_RES: N-acetylalanine => ECO:0000269|PubMed:20454679, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:25944712 |
| 鎖名 | 残基 | 詳細 |
| A | GLU2 | |
| B | GLU2 | |
| C | GLU2 | |
| D | GLU2 |
| site_id | SWS_FT_FI7 |
| 残基数 | 4 |
| 詳細 | MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:Q9CPU0 |
| 鎖名 | 残基 | 詳細 |
| A | ILE88 | |
| B | ILE88 | |
| C | ILE88 | |
| D | ILE88 |
| site_id | SWS_FT_FI8 |
| 残基数 | 4 |
| 詳細 | MOD_RES: Phosphothreonine => ECO:0000269|PubMed:19199007 |
| 鎖名 | 残基 | 詳細 |
| A | GLU107 | |
| B | GLU107 | |
| C | GLU107 | |
| D | GLU107 |
| site_id | SWS_FT_FI9 |
| 残基数 | 4 |
| 詳細 | MOD_RES: S-glutathionyl cysteine; alternate => ECO:0000269|PubMed:20454679 |
| 鎖名 | 残基 | 詳細 |
| A | LYS139 | |
| B | LYS139 | |
| C | LYS139 | |
| D | LYS139 |
| site_id | SWS_FT_FI10 |
| 残基数 | 4 |
| 詳細 | MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:Q9CPU0 |
| 鎖名 | 残基 | 詳細 |
| A | PHE148 | |
| B | PHE148 | |
| C | PHE148 | |
| D | PHE148 |
CSAにおける酵素触媒機能の情報
| site_id | CSA1 |
| 残基数 | 1 |
| 詳細 | Annotated By Reference To The Literature 1fro |
| 鎖名 | 残基 | 詳細 |
| A | GLU172 |
| site_id | CSA2 |
| 残基数 | 1 |
| 詳細 | Annotated By Reference To The Literature 1fro |
| 鎖名 | 残基 | 詳細 |
| B | GLU172 |
| site_id | CSA3 |
| 残基数 | 1 |
| 詳細 | Annotated By Reference To The Literature 1fro |
| 鎖名 | 残基 | 詳細 |
| C | GLU172 |
| site_id | CSA4 |
| 残基数 | 1 |
| 詳細 | Annotated By Reference To The Literature 1fro |
| 鎖名 | 残基 | 詳細 |
| D | GLU172 |
| site_id | MCSA1 |
| 残基数 | 4 |
| 詳細 | M-CSA 32 |
| 鎖名 | 残基 | 詳細 |
| A | THR34 | metal ligand |
| A | LEU100 | hydrogen bond acceptor, hydrogen bond donor, metal ligand, proton acceptor, proton donor |
| A | ILE127 | metal ligand |
| A | ILE173 | hydrogen bond acceptor, metal ligand, proton acceptor, proton donor, proton relay |
| site_id | MCSA2 |
| 残基数 | 4 |
| 詳細 | M-CSA 32 |
| 鎖名 | 残基 | 詳細 |
| B | THR34 | metal ligand |
| B | LEU100 | hydrogen bond acceptor, hydrogen bond donor, metal ligand, proton acceptor, proton donor |
| B | ILE127 | metal ligand |
| B | ILE173 | hydrogen bond acceptor, metal ligand, proton acceptor, proton donor, proton relay |
| site_id | MCSA3 |
| 残基数 | 4 |
| 詳細 | M-CSA 32 |
| 鎖名 | 残基 | 詳細 |
| C | THR34 | metal ligand |
| C | LEU100 | hydrogen bond acceptor, hydrogen bond donor, metal ligand, proton acceptor, proton donor |
| C | ILE127 | metal ligand |
| C | ILE173 | hydrogen bond acceptor, metal ligand, proton acceptor, proton donor, proton relay |
| site_id | MCSA4 |
| 残基数 | 4 |
| 詳細 | M-CSA 32 |
| 鎖名 | 残基 | 詳細 |
| D | THR34 | metal ligand |
| D | LEU100 | hydrogen bond acceptor, hydrogen bond donor, metal ligand, proton acceptor, proton donor |
| D | ILE127 | metal ligand |
| D | ILE173 | hydrogen bond acceptor, metal ligand, proton acceptor, proton donor, proton relay |
