1QIN
HUMAN GLYOXALASE I COMPLEXED WITH S-(N-HYDROXY-N-P-IODOPHENYLCARBAMOYL) GLUTATHIONE
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004462 | molecular_function | lactoylglutathione lyase activity |
A | 0005515 | molecular_function | protein binding |
A | 0005654 | cellular_component | nucleoplasm |
A | 0005737 | cellular_component | cytoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0005886 | cellular_component | plasma membrane |
A | 0005975 | biological_process | carbohydrate metabolic process |
A | 0006357 | biological_process | regulation of transcription by RNA polymerase II |
A | 0006749 | biological_process | glutathione metabolic process |
A | 0008270 | molecular_function | zinc ion binding |
A | 0009438 | biological_process | methylglyoxal metabolic process |
A | 0016829 | molecular_function | lyase activity |
A | 0030316 | biological_process | osteoclast differentiation |
A | 0043066 | biological_process | negative regulation of apoptotic process |
A | 0046872 | molecular_function | metal ion binding |
A | 0070062 | cellular_component | extracellular exosome |
B | 0004462 | molecular_function | lactoylglutathione lyase activity |
B | 0005515 | molecular_function | protein binding |
B | 0005654 | cellular_component | nucleoplasm |
B | 0005737 | cellular_component | cytoplasm |
B | 0005829 | cellular_component | cytosol |
B | 0005886 | cellular_component | plasma membrane |
B | 0005975 | biological_process | carbohydrate metabolic process |
B | 0006357 | biological_process | regulation of transcription by RNA polymerase II |
B | 0006749 | biological_process | glutathione metabolic process |
B | 0008270 | molecular_function | zinc ion binding |
B | 0009438 | biological_process | methylglyoxal metabolic process |
B | 0016829 | molecular_function | lyase activity |
B | 0030316 | biological_process | osteoclast differentiation |
B | 0043066 | biological_process | negative regulation of apoptotic process |
B | 0046872 | molecular_function | metal ion binding |
B | 0070062 | cellular_component | extracellular exosome |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE ZN B 301 |
Chain | Residue |
A | HIS126 |
A | GLU172 |
A | GIP300 |
B | GLN33 |
B | GLU99 |
site_id | AC2 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE ZN A 401 |
Chain | Residue |
A | GLN33 |
A | GLU99 |
B | HIS126 |
B | GLU172 |
B | GIP400 |
site_id | AC3 |
Number of Residues | 27 |
Details | BINDING SITE FOR RESIDUE GIP A 300 |
Chain | Residue |
A | ARG122 |
A | HIS126 |
A | LYS150 |
A | GLY155 |
A | LYS156 |
A | MET157 |
A | LEU160 |
A | PHE162 |
A | GLU172 |
A | MET179 |
A | MET183 |
A | HOH404 |
A | HOH435 |
A | HOH450 |
A | HOH462 |
A | HOH476 |
A | HOH491 |
A | HOH492 |
B | GLN33 |
B | ARG37 |
B | PHE67 |
B | LEU69 |
B | PHE71 |
B | GLU99 |
B | THR101 |
B | ASN103 |
B | ZN301 |
site_id | AC4 |
Number of Residues | 26 |
Details | BINDING SITE FOR RESIDUE GIP B 400 |
Chain | Residue |
B | GLU172 |
B | MET179 |
B | HOH413 |
B | HOH421 |
B | HOH422 |
B | HOH438 |
B | HOH448 |
B | HOH472 |
A | GLN33 |
A | ARG37 |
A | PHE67 |
A | LEU69 |
A | PHE71 |
A | GLU99 |
A | THR101 |
A | ASN103 |
A | ZN401 |
A | HOH406 |
B | ARG122 |
B | HIS126 |
B | LYS150 |
B | GLY155 |
B | LYS156 |
B | MET157 |
B | LEU160 |
B | PHE162 |
site_id | GH1 |
Number of Residues | 3 |
Details | BINDING SITE FOR GSH MOIETY - SUBSTRATE BINDING SITE IS FORMED BY ZN2 HYD2 AND GSH2. |
Chain | Residue |
A | ARG37 |
A | ASN103 |
B | ARG122 |
site_id | GH2 |
Number of Residues | 3 |
Details | BINDING SITE FOR GSH MOIETY - SUBSTRATE BINDING SITE IS FORMED BY ZN1 HYD1 AND GSH1. |
Chain | Residue |
B | ARG37 |
B | ASN103 |
A | ARG122 |
site_id | HD2 |
Number of Residues | 14 |
Details | HYDROPHOBIC SUBSTRATE BINDING POCKET AT DIMER INTERFACE. |
Chain | Residue |
A | CYS60 |
A | PHE62 |
A | MET65 |
A | PHE67 |
A | LEU69 |
A | PHE71 |
A | ILE88 |
A | LEU92 |
B | MET157 |
B | LEU160 |
B | PHE162 |
B | LEU174 |
B | MET179 |
B | MET183 |
site_id | HD3 |
Number of Residues | 14 |
Details | HYDROPHOBIC SUBSTRATE BINDING POCKET AT DIMER INTERFACE. |
Chain | Residue |
B | CYS60 |
B | PHE62 |
B | MET65 |
B | PHE67 |
B | LEU69 |
B | PHE71 |
B | ILE88 |
B | LEU92 |
A | MET157 |
A | LEU160 |
A | PHE162 |
A | LEU174 |
A | MET179 |
A | MET183 |
site_id | ZN1 |
Number of Residues | 5 |
Details | ZINC BINDING SITE AT DIMER INTERFACE. |
Chain | Residue |
A | ZN401 |
A | GLN33 |
A | GLU99 |
B | HIS126 |
B | GLU172 |
site_id | ZN2 |
Number of Residues | 5 |
Details | ZINC BINDING SITE AT DIMER INTERFACE. |
Chain | Residue |
A | GLU172 |
B | ZN301 |
B | GLN33 |
B | GLU99 |
A | HIS126 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | ACT_SITE: Proton donor/acceptor => ECO:0000269|PubMed:10521255, ECO:0000269|PubMed:9705294 |
Chain | Residue | Details |
A | ILE173 | |
B | ILE173 |
site_id | SWS_FT_FI2 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000269|PubMed:23122816, ECO:0000269|PubMed:9218781, ECO:0000269|PubMed:9705294 |
Chain | Residue | Details |
A | THR34 | |
A | LEU100 | |
B | THR34 | |
B | LEU100 |
site_id | SWS_FT_FI3 |
Number of Residues | 4 |
Details | BINDING: |
Chain | Residue | Details |
A | VAL38 | |
A | TRP104 | |
B | VAL38 | |
B | TRP104 |
site_id | SWS_FT_FI4 |
Number of Residues | 4 |
Details | BINDING: in other chain |
Chain | Residue | Details |
A | GLY123 | |
A | MET157 | |
B | GLY123 | |
B | MET157 |
site_id | SWS_FT_FI5 |
Number of Residues | 4 |
Details | BINDING: in other chain => ECO:0000269|PubMed:23122816, ECO:0000269|PubMed:9218781, ECO:0000269|PubMed:9705294 |
Chain | Residue | Details |
A | ILE127 | |
A | ILE173 | |
B | ILE127 | |
B | ILE173 |
site_id | SWS_FT_FI6 |
Number of Residues | 2 |
Details | MOD_RES: N-acetylalanine => ECO:0000269|PubMed:20454679, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:25944712 |
Chain | Residue | Details |
A | GLU2 | |
B | GLU2 |
site_id | SWS_FT_FI7 |
Number of Residues | 2 |
Details | MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:Q9CPU0 |
Chain | Residue | Details |
A | ILE88 | |
B | ILE88 |
site_id | SWS_FT_FI8 |
Number of Residues | 2 |
Details | MOD_RES: Phosphothreonine => ECO:0000269|PubMed:19199007 |
Chain | Residue | Details |
A | GLU107 | |
B | GLU107 |
site_id | SWS_FT_FI9 |
Number of Residues | 2 |
Details | MOD_RES: S-glutathionyl cysteine; alternate => ECO:0000269|PubMed:20454679 |
Chain | Residue | Details |
A | LYS139 | |
B | LYS139 |
site_id | SWS_FT_FI10 |
Number of Residues | 2 |
Details | MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:Q9CPU0 |
Chain | Residue | Details |
A | PHE148 | |
B | PHE148 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 1fro |
Chain | Residue | Details |
A | GLU172 |
site_id | CSA2 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 1fro |
Chain | Residue | Details |
B | GLU172 |
site_id | MCSA1 |
Number of Residues | 4 |
Details | M-CSA 32 |
Chain | Residue | Details |
A | THR34 | metal ligand |
A | LEU100 | hydrogen bond acceptor, hydrogen bond donor, metal ligand, proton acceptor, proton donor |
A | ILE127 | metal ligand |
A | ILE173 | hydrogen bond acceptor, metal ligand, proton acceptor, proton donor, proton relay |
site_id | MCSA2 |
Number of Residues | 4 |
Details | M-CSA 32 |
Chain | Residue | Details |
B | THR34 | metal ligand |
B | LEU100 | hydrogen bond acceptor, hydrogen bond donor, metal ligand, proton acceptor, proton donor |
B | ILE127 | metal ligand |
B | ILE173 | hydrogen bond acceptor, metal ligand, proton acceptor, proton donor, proton relay |