1GSF

GLUTATHIONE TRANSFERASE A1-1 COMPLEXED WITH ETHACRYNIC ACID

GO（遺伝子オントロジー）由来の情報

鎖名	GO（遺伝子オントロジー）id	名前空間	内容
A	0004364	molecular_function	glutathione transferase activity
A	0004601	molecular_function	peroxidase activity
A	0004602	molecular_function	glutathione peroxidase activity
A	0004769	molecular_function	steroid delta-isomerase activity
A	0005504	molecular_function	fatty acid binding
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006629	biological_process	lipid metabolic process
A	0006693	biological_process	prostaglandin metabolic process
A	0006749	biological_process	glutathione metabolic process
A	0006805	biological_process	xenobiotic metabolic process
A	0016740	molecular_function	transferase activity
A	0016853	molecular_function	isomerase activity
A	0030855	biological_process	epithelial cell differentiation
A	0043651	biological_process	linoleic acid metabolic process
A	0070062	cellular_component	extracellular exosome
A	0098869	biological_process	cellular oxidant detoxification
A	1901687	biological_process	glutathione derivative biosynthetic process
B	0004364	molecular_function	glutathione transferase activity
B	0004601	molecular_function	peroxidase activity
B	0004602	molecular_function	glutathione peroxidase activity
B	0004769	molecular_function	steroid delta-isomerase activity
B	0005504	molecular_function	fatty acid binding
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006629	biological_process	lipid metabolic process
B	0006693	biological_process	prostaglandin metabolic process
B	0006749	biological_process	glutathione metabolic process
B	0006805	biological_process	xenobiotic metabolic process
B	0016740	molecular_function	transferase activity
B	0016853	molecular_function	isomerase activity
B	0030855	biological_process	epithelial cell differentiation
B	0043651	biological_process	linoleic acid metabolic process
B	0070062	cellular_component	extracellular exosome
B	0098869	biological_process	cellular oxidant detoxification
B	1901687	biological_process	glutathione derivative biosynthetic process
C	0004364	molecular_function	glutathione transferase activity
C	0004601	molecular_function	peroxidase activity
C	0004602	molecular_function	glutathione peroxidase activity
C	0004769	molecular_function	steroid delta-isomerase activity
C	0005504	molecular_function	fatty acid binding
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006629	biological_process	lipid metabolic process
C	0006693	biological_process	prostaglandin metabolic process
C	0006749	biological_process	glutathione metabolic process
C	0006805	biological_process	xenobiotic metabolic process
C	0016740	molecular_function	transferase activity
C	0016853	molecular_function	isomerase activity
C	0030855	biological_process	epithelial cell differentiation
C	0043651	biological_process	linoleic acid metabolic process
C	0070062	cellular_component	extracellular exosome
C	0098869	biological_process	cellular oxidant detoxification
C	1901687	biological_process	glutathione derivative biosynthetic process
D	0004364	molecular_function	glutathione transferase activity
D	0004601	molecular_function	peroxidase activity
D	0004602	molecular_function	glutathione peroxidase activity
D	0004769	molecular_function	steroid delta-isomerase activity
D	0005504	molecular_function	fatty acid binding
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006629	biological_process	lipid metabolic process
D	0006693	biological_process	prostaglandin metabolic process
D	0006749	biological_process	glutathione metabolic process
D	0006805	biological_process	xenobiotic metabolic process
D	0016740	molecular_function	transferase activity
D	0016853	molecular_function	isomerase activity
D	0030855	biological_process	epithelial cell differentiation
D	0043651	biological_process	linoleic acid metabolic process
D	0070062	cellular_component	extracellular exosome
D	0098869	biological_process	cellular oxidant detoxification
D	1901687	biological_process	glutathione derivative biosynthetic process

PDBデータベースに由来する情報

site_id	AC1
残基数	11
詳細	BINDING SITE FOR RESIDUE EAA A 223

鎖名	残基
A	TYR9
A	HOH271
A	HOH288
A	PHE10
A	GLY14
A	ARG15
A	VAL55
A	LEU107
A	VAL111
A	MET208
A	PHE220

---

site_id	AC2
残基数	11
詳細	BINDING SITE FOR RESIDUE EAA B 223

鎖名	残基
B	TYR9
B	PHE10
B	GLY14
B	ARG15
B	VAL55
B	LEU107
B	VAL111
B	MET208
B	PHE220
B	HOH276
B	HOH293

---

site_id	AC3
残基数	9
詳細	BINDING SITE FOR RESIDUE EAA C 223

鎖名	残基
C	TYR9
C	PHE10
C	GLY14
C	ARG15
C	VAL55
C	LEU107
C	VAL111
C	MET208
C	PHE220

---

site_id	AC4
残基数	9
詳細	BINDING SITE FOR RESIDUE EAA D 223

鎖名	残基
D	TYR9
D	PHE10
D	GLY14
D	ARG15
D	VAL55
D	LEU107
D	VAL111
D	MET208
D	PHE220

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SwissProt/UniProtに記載されている蛋白質分子機能情報

site_id	SWS_FT_FI1
残基数	16
詳細	BINDING: BINDING => ECO:0000269|PubMed:16421451, ECO:0000269|PubMed:19618965

鎖名	残基	詳細
A	PHE10
C	ASN46
C	VAL55
C	THR68
D	PHE10
D	ASN46
D	VAL55
D	THR68
A	ASN46
A	VAL55
A	THR68
B	PHE10
B	ASN46
B	VAL55
B	THR68
C	PHE10

---

site_id	SWS_FT_FI2
残基数	4
詳細	MOD_RES: N-acetylmethionine => ECO:0000250|UniProtKB:P80894

鎖名	残基	詳細
A	ALA2
B	ALA2
C	ALA2
D	ALA2

---

site_id	SWS_FT_FI3
残基数	4
詳細	MOD_RES: N-acetylalanine; in Glutathione S-transferase A1, N-terminally processed => ECO:0000250|UniProtKB:P30115

鎖名	残基	詳細
A	GLU3
B	GLU3
C	GLU3
D	GLU3

---

site_id	SWS_FT_FI4
残基数	4
詳細	MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:P30115

鎖名	残基	詳細
A	PRO5
B	PRO5
C	PRO5
D	PRO5

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CSAにおける酵素触媒機能の情報

site_id	CSA1
残基数	1
詳細	Annotated By Reference To The Literature 1oe8

鎖名	残基	詳細
A	TYR9

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site_id	CSA2
残基数	1
詳細	Annotated By Reference To The Literature 1oe8

鎖名	残基	詳細
B	TYR9

---

site_id	CSA3
残基数	1
詳細	Annotated By Reference To The Literature 1oe8

鎖名	残基	詳細
C	TYR9

---

site_id	CSA4
残基数	1
詳細	Annotated By Reference To The Literature 1oe8

鎖名	残基	詳細
D	TYR9

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