1FUO
FUMARASE C WITH BOUND CITRATE
GO（遺伝子オントロジー）由来の情報
| 鎖名 | GO（遺伝子オントロジー）id | 名前空間 | 内容 |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004333 | molecular_function | fumarate hydratase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006099 | biological_process | tricarboxylic acid cycle |
| A | 0006106 | biological_process | fumarate metabolic process |
| A | 0006108 | biological_process | malate metabolic process |
| A | 0006979 | biological_process | response to oxidative stress |
| A | 0016829 | molecular_function | lyase activity |
| A | 0042802 | molecular_function | identical protein binding |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004333 | molecular_function | fumarate hydratase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006099 | biological_process | tricarboxylic acid cycle |
| B | 0006106 | biological_process | fumarate metabolic process |
| B | 0006108 | biological_process | malate metabolic process |
| B | 0006979 | biological_process | response to oxidative stress |
| B | 0016829 | molecular_function | lyase activity |
| B | 0042802 | molecular_function | identical protein binding |
PDBデータベースに由来する情報
| site_id | AC1 |
| 残基数 | 5 |
| 詳細 | BINDING SITE FOR RESIDUE MLT A 468 |
| 鎖名 | 残基 |
| A | ARG126 |
| A | HIS129 |
| A | PRO130 |
| A | ASN131 |
| A | ASP132 |
| site_id | AC2 |
| 残基数 | 5 |
| 詳細 | BINDING SITE FOR RESIDUE MLT B 468 |
| 鎖名 | 残基 |
| B | ASP132 |
| B | ARG126 |
| B | HIS129 |
| B | PRO130 |
| B | ASN131 |
| site_id | AC3 |
| 残基数 | 11 |
| 詳細 | BINDING SITE FOR RESIDUE CIT A 469 |
| 鎖名 | 残基 |
| A | THR100 |
| A | SER139 |
| A | SER140 |
| A | ASN141 |
| A | LYS324 |
| A | ASN326 |
| A | HOH506 |
| A | HOH666 |
| A | HOH684 |
| B | THR187 |
| B | HIS188 |
| site_id | AC4 |
| 残基数 | 9 |
| 詳細 | BINDING SITE FOR RESIDUE CIT B 469 |
| 鎖名 | 残基 |
| A | THR187 |
| A | HIS188 |
| B | THR100 |
| B | SER139 |
| B | SER140 |
| B | ASN141 |
| B | LYS324 |
| B | ASN326 |
| B | HOH482 |
UniProtにおけるモチーフ・データベースPROSITEからの機能情報
SwissProt/UniProtに記載されている蛋白質分子機能情報
| site_id | SWS_FT_FI1 |
| 残基数 | 2 |
| 詳細 | ACT_SITE: Proton donor/acceptor => ECO:0000255|HAMAP-Rule:MF_00743, ECO:0000269|PubMed:9098893 |
| 鎖名 | 残基 | 詳細 |
| A | HIS188 | |
| B | HIS188 |
| site_id | SWS_FT_FI2 |
| 残基数 | 2 |
| 詳細 | ACT_SITE: ACT_SITE => ECO:0000255|HAMAP-Rule:MF_00743 |
| 鎖名 | 残基 | 詳細 |
| A | SER318 | |
| B | SER318 |
| site_id | SWS_FT_FI3 |
| 残基数 | 2 |
| 詳細 | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00743, ECO:0000305|PubMed:12021453, ECO:0000305|PubMed:8909293, ECO:0000305|PubMed:9098893, ECO:0007744|PDB:1FUO, ECO:0007744|PDB:1FUP, ECO:0007744|PDB:1FUQ, ECO:0007744|PDB:1KQ7, ECO:0007744|PDB:2FUS |
| 鎖名 | 残基 | 詳細 |
| A | SER98 | |
| B | SER98 |
| site_id | SWS_FT_FI4 |
| 残基数 | 2 |
| 詳細 | BINDING: BINDING => ECO:0000269|PubMed:8909293, ECO:0000269|PubMed:9098893, ECO:0007744|PDB:1FUO, ECO:0007744|PDB:1FUP, ECO:0007744|PDB:1FUQ, ECO:0007744|PDB:1FUR |
| 鎖名 | 残基 | 詳細 |
| A | ARG126 | |
| B | ARG126 |
| site_id | SWS_FT_FI5 |
| 残基数 | 2 |
| 詳細 | BINDING: in site B => ECO:0000269|PubMed:12021453, ECO:0000269|PubMed:8909293, ECO:0000269|PubMed:9098893, ECO:0007744|PDB:1FUO, ECO:0007744|PDB:1FUP, ECO:0007744|PDB:1FUQ, ECO:0007744|PDB:1FUR, ECO:0007744|PDB:1KQ7 |
| 鎖名 | 残基 | 詳細 |
| A | HIS129 | |
| B | HIS129 |
| site_id | SWS_FT_FI6 |
| 残基数 | 2 |
| 詳細 | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00743, ECO:0000269|PubMed:12021453, ECO:0000269|PubMed:8909293, ECO:0000269|PubMed:9098893, ECO:0007744|PDB:1FUO, ECO:0007744|PDB:1FUP, ECO:0007744|PDB:1FUQ, ECO:0007744|PDB:1KQ7, ECO:0007744|PDB:2FUS |
| 鎖名 | 残基 | 詳細 |
| A | SER139 | |
| B | SER139 |
| site_id | SWS_FT_FI7 |
| 残基数 | 6 |
| 詳細 | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00743 |
| 鎖名 | 残基 | 詳細 |
| A | THR187 | |
| A | SER319 | |
| A | LYS324 | |
| B | THR187 | |
| B | SER319 | |
| B | LYS324 |
| site_id | SWS_FT_FI8 |
| 残基数 | 2 |
| 詳細 | SITE: Important for catalytic activity => ECO:0000255|HAMAP-Rule:MF_00743, ECO:0000305|PubMed:8909293 |
| 鎖名 | 残基 | 詳細 |
| A | GLU331 | |
| B | GLU331 |
CSAにおける酵素触媒機能の情報
| site_id | CSA1 |
| 残基数 | 4 |
| 詳細 | Annotated By Reference To The Literature 1auw |
| 鎖名 | 残基 | 詳細 |
| A | THR187 | |
| A | HIS188 | |
| B | GLU331 | |
| B | LYS324 |
| site_id | CSA2 |
| 残基数 | 5 |
| 詳細 | Annotated By Reference To The Literature 1auw |
| 鎖名 | 残基 | 詳細 |
| A | GLU331 | |
| A | SER318 | |
| A | LYS324 | |
| B | THR187 | |
| B | HIS188 |
| site_id | MCSA1 |
| 残基数 | 4 |
| 詳細 | M-CSA 569 |
| 鎖名 | 残基 | 詳細 |
| A | HIS188 | electrostatic stabiliser, proton acceptor |
| A | SER318 | proton donor |
| A | LYS324 | electrostatic stabiliser |
| A | GLU331 | increase basicity |
| site_id | MCSA2 |
| 残基数 | 4 |
| 詳細 | M-CSA 569 |
| 鎖名 | 残基 | 詳細 |
| B | HIS188 | electrostatic stabiliser, proton acceptor |
| B | SER318 | proton donor |
| B | LYS324 | electrostatic stabiliser |
| B | GLU331 | increase basicity |
