1AE4
ALDEHYDE REDUCTASE COMPLEXED WITH COFACTOR AND INHIBITOR, ALPHA CARBON ATOMS ONLY
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004032 | molecular_function | aldose reductase (NADPH) activity |
A | 0004745 | molecular_function | all-trans-retinol dehydrogenase (NAD+) activity |
A | 0005737 | cellular_component | cytoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0005886 | cellular_component | plasma membrane |
A | 0006629 | biological_process | lipid metabolic process |
A | 0008106 | molecular_function | alcohol dehydrogenase (NADP+) activity |
A | 0016324 | cellular_component | apical plasma membrane |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0019853 | biological_process | L-ascorbic acid biosynthetic process |
A | 0042840 | biological_process | D-glucuronate catabolic process |
A | 0046185 | biological_process | aldehyde catabolic process |
A | 0047655 | molecular_function | allyl-alcohol dehydrogenase activity |
A | 0047939 | molecular_function | L-glucuronate reductase activity |
A | 0047941 | molecular_function | glucuronolactone reductase activity |
A | 0047956 | molecular_function | glycerol dehydrogenase (NADP+) activity |
A | 0110095 | biological_process | cellular detoxification of aldehyde |
A | 0160163 | molecular_function | S-nitrosoglutathione reductase (NADPH) activity |
A | 1990002 | molecular_function | methylglyoxal reductase (NADPH) (acetol producing) activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE NAP A 350 |
Chain | Residue |
A | GLY20 |
A | TRP22 |
A | SER211 |
A | LEU213 |
A | SER215 |
A | PRO262 |
A | SER264 |
A | TOL600 |
site_id | AC2 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE TOL A 600 |
Chain | Residue |
A | NAP350 |
Functional Information from PROSITE/UniProt
site_id | PS00062 |
Number of Residues | 18 |
Details | ALDOKETO_REDUCTASE_2 Aldo/keto reductase family signature 2. LealvakglVRALGLSNF |
Chain | Residue | Details |
A | LEU147-PHE164 |
site_id | PS00063 |
Number of Residues | 16 |
Details | ALDOKETO_REDUCTASE_3 Aldo/keto reductase family putative active site signature. IPKSVTpsRIpQNiQV |
Chain | Residue | Details |
A | ILE261-VAL276 |
site_id | PS00798 |
Number of Residues | 18 |
Details | ALDOKETO_REDUCTASE_1 Aldo/keto reductase family signature 1. GYRHIDCAaiygnEleIG |
Chain | Residue | Details |
A | GLY40-GLY57 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 1 |
Details | ACT_SITE: Proton donor => ECO:0000269|PubMed:11306083, ECO:0000269|PubMed:7552731 |
Chain | Residue | Details |
A | GLY51 |
site_id | SWS_FT_FI2 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000250|UniProtKB:O60218 |
Chain | Residue | Details |
A | GLN12 |
site_id | SWS_FT_FI3 |
Number of Residues | 15 |
Details | BINDING: BINDING => ECO:0000269|PubMed:11306083, ECO:0007744|PDB:1HQT |
Chain | Residue | Details |
A | TRP22 | |
A | SER264 | |
A | VAL265 | |
A | THR266 | |
A | PRO267 | |
A | ILE270 | |
A | ILE274 | |
A | LYS23 | |
A | CYS46 | |
A | ASN163 | |
A | PHE164 | |
A | PRO212 | |
A | GLY214 | |
A | SER216 | |
A | ASP217 |
site_id | SWS_FT_FI4 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:11306083, ECO:0007744|PDB:3CV7 |
Chain | Residue | Details |
A | ASN273 |
site_id | SWS_FT_FI5 |
Number of Residues | 1 |
Details | SITE: Lowers pKa of active site Tyr => ECO:0000250|UniProtKB:P14550 |
Chain | Residue | Details |
A | LEU81 |
site_id | SWS_FT_FI6 |
Number of Residues | 1 |
Details | MOD_RES: N-acetylalanine => ECO:0000250|UniProtKB:P14550 |
Chain | Residue | Details |
A | ALA3 |
site_id | SWS_FT_FI7 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P51635 |
Chain | Residue | Details |
A | CYS5 |
site_id | SWS_FT_FI8 |
Number of Residues | 1 |
Details | MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:Q9JII6 |
Chain | Residue | Details |
A | ASN128 |
site_id | SWS_FT_FI9 |
Number of Residues | 1 |
Details | MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:Q9JII6 |
Chain | Residue | Details |
A | ALA146 |
site_id | SWS_FT_FI10 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P14550 |
Chain | Residue | Details |
A | PRO212 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1mrq |
Chain | Residue | Details |
A | LYS80 | |
A | HIS113 | |
A | ASP45 | |
A | TYR50 |
site_id | CSA2 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1mrq |
Chain | Residue | Details |
A | LYS80 | |
A | TYR50 |