Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

5HG7

EGFR (L858R, T790M, V948R) in complex with 1-{(3R,4R)-3-[5-Chloro-2-(1-methyl-1H-pyrazol-4-ylamino)-7H-pyrrolo[2,3-d]pyrimidin-4-yloxymethyl]-4-methoxy-pyrrolidin-1-yl}propenone (PF-06459988)

Experimental procedure
Experimental methodSINGLE WAVELENGTH
Source typeSYNCHROTRON
Source detailsDIAMOND BEAMLINE I03
Synchrotron siteDiamond
BeamlineI03
Temperature [K]98
Detector technologyPIXEL
Collection date2012-02-03
DetectorDECTRIS PILATUS 6M
Wavelength(s)0.97630
Spacegroup nameP 21 21 21
Unit cell lengths35.110, 70.000, 112.880
Unit cell angles90.00, 90.00, 90.00
Refinement procedure
Resolution59.490 - 1.850
R-factor0.216
Rwork0.215
R-free0.24600
Structure solution methodMOLECULAR REPLACEMENT
RMSD bond length0.004
RMSD bond angle0.800
Data scaling softwareSCALA
Refinement softwareCNX (2005)
Data quality characteristics
 OverallOuter shell
Low resolution limit [Å]59.4901.880
High resolution limit [Å]1.8301.830
Rmerge0.752
Number of reflections24860
<I/σ(I)>16.83.5
Completeness [%]98.699.9
Redundancy12.612.8
Crystallization Conditions
crystal IDmethodpHtemperaturedetails
1VAPOR DIFFUSION, SITTING DROP2860.1 M (5.0 uL of stock 1.0 M) HEPES (pH 7.50), 0.2 M (2.5 uL of stock 4.0 M) Ammonium sulfate, 10.0 %v/v (5.0 uL of stock 100.0 %v/v) iso-propanol, 20.0 %w/v (20.0 uL of stock 50.0 %w/v) PEG 8000

225158

數據於2024-09-18公開中

PDB statisticsPDBj update infoContact PDBjnumon