7HL0
 
 | | Group deposition for crystallographic fragment screening of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2 -- Crystal structure of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2 in complex with NCL-00023818 (DNV2_NS5A-x0963) | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 4-IODOPYRAZOLE, DI(HYDROXYETHYL)ETHER, ... | | Authors: | Saini, M, Chopra, A, Aschenbrenner, J.C, Marples, P.G, Balcomb, B.H, Fearon, D, von Delft, F, Ruiz, F.X, Arnold, E. | | Deposit date: | 2024-10-15 | | Release date: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (2.23 Å) | | Cite: | Group deposition for crystallographic fragment screening of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2
To Be Published
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7HL1
 | | Group deposition for crystallographic fragment screening of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2 -- Crystal structure of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2 in complex with Z3241250482 (DNV2_NS5A-x1037) | | Descriptor: | 1,1-bis(oxidanylidene)thietan-3-ol, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, DI(HYDROXYETHYL)ETHER, ... | | Authors: | Saini, M, Chopra, A, Aschenbrenner, J.C, Marples, P.G, Balcomb, B.H, Fearon, D, von Delft, F, Ruiz, F.X, Arnold, E. | | Deposit date: | 2024-10-15 | | Release date: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (1.66 Å) | | Cite: | Group deposition for crystallographic fragment screening of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2
To Be Published
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7HL2
 | | Group deposition for crystallographic fragment screening of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2 -- Crystal structure of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2 in complex with Z3219959731 (DNV2_NS5A-x1046) | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, DI(HYDROXYETHYL)ETHER, DIMETHYL SULFOXIDE, ... | | Authors: | Saini, M, Chopra, A, Aschenbrenner, J.C, Marples, P.G, Balcomb, B.H, Fearon, D, von Delft, F, Ruiz, F.X, Arnold, E. | | Deposit date: | 2024-10-15 | | Release date: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (1.84 Å) | | Cite: | Group deposition for crystallographic fragment screening of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2
To Be Published
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7HL3
 | | Group deposition for crystallographic fragment screening of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2 -- Crystal structure of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2 in complex with Z1741972704 (DNV2_NS5A-x1073) | | Descriptor: | 1,2-oxazol-3-amine, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, DI(HYDROXYETHYL)ETHER, ... | | Authors: | Saini, M, Chopra, A, Aschenbrenner, J.C, Marples, P.G, Balcomb, B.H, Fearon, D, von Delft, F, Ruiz, F.X, Arnold, E. | | Deposit date: | 2024-10-15 | | Release date: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | Group deposition for crystallographic fragment screening of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2
To Be Published
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7HL4
 | | Group deposition for crystallographic fragment screening of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2 -- Crystal structure of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2 in complex with HL11 (DNV2_NS5A-x1094) | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-bromopyrimidine, DI(HYDROXYETHYL)ETHER, ... | | Authors: | Saini, M, Chopra, A, Aschenbrenner, J.C, Marples, P.G, Balcomb, B.H, Fearon, D, von Delft, F, Ruiz, F.X, Arnold, E. | | Deposit date: | 2024-10-15 | | Release date: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (1.78 Å) | | Cite: | Group deposition for crystallographic fragment screening of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2
To Be Published
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7HL5
 | | Group deposition for crystallographic fragment screening of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2 -- Crystal structure of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2 in complex with Z44548882 (DNV2_NS5A-x1149) | | Descriptor: | 1,1-diphenylmethanamine, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, DI(HYDROXYETHYL)ETHER, ... | | Authors: | Saini, M, Chopra, A, Aschenbrenner, J.C, Marples, P.G, Balcomb, B.H, Fearon, D, von Delft, F, Ruiz, F.X, Arnold, E. | | Deposit date: | 2024-10-15 | | Release date: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (1.63 Å) | | Cite: | Group deposition for crystallographic fragment screening of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2
To Be Published
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7HL6
 | | Group deposition for crystallographic fragment screening of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2 -- Crystal structure of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2 in complex with Z31113727 (DNV2_NS5A-x1192) | | Descriptor: | 1-(pyridin-2-yl)piperidin-4-one, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, DI(HYDROXYETHYL)ETHER, ... | | Authors: | Saini, M, Chopra, A, Aschenbrenner, J.C, Marples, P.G, Balcomb, B.H, Fearon, D, von Delft, F, Ruiz, F.X, Arnold, E. | | Deposit date: | 2024-10-15 | | Release date: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Group deposition for crystallographic fragment screening of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2
To Be Published
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7HL7
 | | Group deposition for crystallographic fragment screening of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2 -- Crystal structure of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2 in complex with Z48978335 (DNV2_NS5A-x1196) | | Descriptor: | 1'H-spiro[cyclopentane-1,2'-quinazolin]-4'(3'H)-one, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, DI(HYDROXYETHYL)ETHER, ... | | Authors: | Saini, M, Chopra, A, Aschenbrenner, J.C, Marples, P.G, Balcomb, B.H, Fearon, D, von Delft, F, Ruiz, F.X, Arnold, E. | | Deposit date: | 2024-10-15 | | Release date: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (1.66 Å) | | Cite: | Group deposition for crystallographic fragment screening of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2
To Be Published
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7HL8
 | | Group deposition for crystallographic fragment screening of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2 -- Crystal structure of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2 in complex with Z57157143 (DNV2_NS5A-x1212) | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, DI(HYDROXYETHYL)ETHER, DIMETHYL SULFOXIDE, ... | | Authors: | Saini, M, Chopra, A, Aschenbrenner, J.C, Marples, P.G, Balcomb, B.H, Fearon, D, von Delft, F, Ruiz, F.X, Arnold, E. | | Deposit date: | 2024-10-15 | | Release date: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (1.86 Å) | | Cite: | Group deposition for crystallographic fragment screening of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2
To Be Published
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7HL9
 | | Group deposition for crystallographic fragment screening of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2 -- Crystal structure of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2 in complex with Z53833304 (DNV2_NS5A-x1217) | | Descriptor: | 1-ethyl-1H-benzimidazole, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, DI(HYDROXYETHYL)ETHER, ... | | Authors: | Saini, M, Chopra, A, Aschenbrenner, J.C, Marples, P.G, Balcomb, B.H, Fearon, D, von Delft, F, Ruiz, F.X, Arnold, E. | | Deposit date: | 2024-10-15 | | Release date: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | Group deposition for crystallographic fragment screening of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2
To Be Published
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7LZ6
 | | The Cryo-EM structure of a complex between GAD65 and b96.11 Fab | | Descriptor: | Glutamate decarboxylase 2, b96.11 Fab heavy chain, b96.11 Fab light chain | | Authors: | Reboul, C.F, Le, S.N, Williams, D.E, Buckle, A.M. | | Deposit date: | 2021-03-09 | | Release date: | 2024-10-30 | | Method: | ELECTRON MICROSCOPY (7.3 Å) | | Cite: | Structure and dynamics of the autoantigen GAD65 in complex with the human autoimmune polyendocrine syndrome type 2-associated autoantibody b96.11
Biorxiv, 2024
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8G4I
 | | 40S ribosomal subunit of the 80S Giardia intestinalis assemblage A ribosome with Emetine bound in V1 conformation | | Descriptor: | 18S rRNA, 40S ribosomal protein S21, 40S ribosomal protein S25, ... | | Authors: | Eiler, D.R, Wimberly, B.T, Bilodeau, D.Y, Rissland, O.S, Kieft, J.S. | | Deposit date: | 2023-02-09 | | Release date: | 2024-10-30 | | Method: | ELECTRON MICROSCOPY (3.24 Å) | | Cite: | The Giardia lamblia ribosome structure reveals divergence in several biological pathways and the mode of emetine function.
Structure, 32, 2024
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8IHU
 | | Cryo-EM structure of an amyloid fibril formed by ALS-causing SOD1 mutation G85R | | Descriptor: | Superoxide dismutase [Cu-Zn] | | Authors: | Wang, L.Q, Ma, Y.Y, Zhang, M.Y, Yuan, H.Y, Li, X.N, Zhao, K, Chen, J, Li, D, Wang, Z.Z, Le, W.D, Liu, C, Liang, Y. | | Deposit date: | 2023-02-23 | | Release date: | 2024-10-30 | | Method: | ELECTRON MICROSCOPY (2.97 Å) | | Cite: | Amyloid fibril structures and ferroptosis activation induced by ALS-causing SOD1 mutations.
Sci Adv, 2024
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8IHV
 | | Cryo-EM structure of an amyloid fibril formed by ALS-causing SOD1 mutation H46R | | Descriptor: | Superoxide dismutase [Cu-Zn] | | Authors: | Wang, L.Q, Ma, Y.Y, Zhang, M.Y, Yuan, H.Y, Li, X.N, Zhao, K, Chen, J, Li, D, Wang, Z.Z, Le, W.D, Liu, C, Liang, Y. | | Deposit date: | 2023-02-23 | | Release date: | 2024-10-30 | | Method: | ELECTRON MICROSCOPY (3.11 Å) | | Cite: | Amyloid fibril structures and ferroptosis activation induced by ALS-causing SOD1 mutations.
Sci Adv, 2024
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8ORJ
 | | Cryo-EM structure of human tRNA ligase RTCB in complex with human PYROXD1. | | Descriptor: | DIHYDROFLAVINE-ADENINE DINUCLEOTIDE, MAGNESIUM ION, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... | | Authors: | Loeff, L, Kroupova, A, Asanovic, I, Boneberg, F, Pfleiderer, M.M, Ferdigg, A, Ackle, F, Martinez, J, Jinek, M. | | Deposit date: | 2023-04-14 | | Release date: | 2024-10-30 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Mechanistic basis for oxidative stress protection of the human tRNA ligase complex by the oxidoreductase PYROXD1
BioRxiv, 2023
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8PUU
 | | Giardia intestinales deoxyadenosine kinase forms a functional tetramer | | Descriptor: | 2'-DEOXYADENOSINE-5'-DIPHOSPHATE, 2'-DEOXYADENOSINE-5'-MONOPHOSPHATE, Deoxynucleoside kinase, ... | | Authors: | Ranjbarian, F, Rafie, K, Shankar, K, Krakovka, S, Svaerd, S, Carlson, L.-A, Hofer, A. | | Deposit date: | 2023-07-17 | | Release date: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Giardia intestinalis deoxyadenosine kinase has a unique tetrameric structure that enables high substrate affinity and makes the parasite sensitive to deoxyadenosine analogues
To Be Published
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8QDQ
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8QDR
 | | Vitis vinifera dimeric 13S-lipoxygenase LOXA in a detergent bound open conformation | | Descriptor: | 1,2-ETHANEDIOL, 3,6,12,15,18,21,24-HEPTAOXAHEXATRIACONTAN-1-OL, FE (III) ION, ... | | Authors: | Wild, K, Sinning, I. | | Deposit date: | 2023-08-30 | | Release date: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Vitis vinifera lipoxygenase LoxA is an allosteric dimer activated by lipidic surfaces.
J.Mol.Biol., 2024
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8QL2
 | | Ultrafast structural transitions in an azobenzene photoswitch at near-atomic resolution: dark structure | | Descriptor: | Azo-Combretastatin A4 (cis), CALCIUM ION, Designed Ankyrin Repeat Protein (DARPIN) D1, ... | | Authors: | Weinert, T, Wranik, M, Seidel, H.-P, Church, J, Steinmetz, M.O, Schapiro, I, Standfuss, J. | | Deposit date: | 2023-09-19 | | Release date: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Ultrafast structural transitions in an azobenzene photoswitch at near-atomic resolution
To Be Published
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8QMU
 | | The complex of Glycogen Phosphorylase with (-)-Epigallocatechin-3-gallate (EGCG). | | Descriptor: | (2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl 3,4,5-trihydroxybenzoate, DIMETHYL SULFOXIDE, Glycogen phosphorylase, ... | | Authors: | Alexopoulos, S, Papakostopoulou, S, Koulas, M.S, Leonidas, D.D, Skamnaki, V. | | Deposit date: | 2023-09-25 | | Release date: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Evidence for the Quercetin Binding Site of Glycogen Phosphorylase as a Target for Liver-Isoform-Selective Inhibitors against Glioblastoma: Investigation of Flavanols Epigallocatechin Gallate and Epigallocatechin.
J.Agric.Food Chem., 2024
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8QVN
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8QVT
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8QVX
 | | Structure of the PBD of human SRP68/72 (cryoSPARC 3DFlex) | | Descriptor: | Signal recognition particle subunit SRP68, Signal recognition particle subunit SRP72 | | Authors: | Zhong, Y, Feng, J, Koh, A.F, Kotecha, A, Greber, B.J, Ataide, S.F. | | Deposit date: | 2023-10-18 | | Release date: | 2024-10-30 | | Method: | ELECTRON MICROSCOPY (2.7 Å) | | Cite: | To be published
To Be Published
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8QX1
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8QX3
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