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Yorodumi- PDB-6br1: Tubulin-RB3_SLD-TTL in complex with heterocyclic pyrimidine compo... -
+Open data
-Basic information
Entry | Database: PDB / ID: 6br1 | ||||||
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Title | Tubulin-RB3_SLD-TTL in complex with heterocyclic pyrimidine compound 4a | ||||||
Components |
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Keywords | CELL CYCLE/INHIBITOR / Microtubule Inhibitor / Colchicine Cancer / CELL CYCLE / CELL CYCLE-INHIBITOR complex | ||||||
Function / homology | Function and homology information tubulin-tyrosine ligase activity / Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane / Hedgehog 'off' state / Cilium Assembly / Intraflagellar transport / COPI-dependent Golgi-to-ER retrograde traffic / Carboxyterminal post-translational modifications of tubulin / RHOH GTPase cycle / Sealing of the nuclear envelope (NE) by ESCRT-III / Kinesins ...tubulin-tyrosine ligase activity / Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane / Hedgehog 'off' state / Cilium Assembly / Intraflagellar transport / COPI-dependent Golgi-to-ER retrograde traffic / Carboxyterminal post-translational modifications of tubulin / RHOH GTPase cycle / Sealing of the nuclear envelope (NE) by ESCRT-III / Kinesins / PKR-mediated signaling / The role of GTSE1 in G2/M progression after G2 checkpoint / Aggrephagy / Resolution of Sister Chromatid Cohesion / Mitotic Prometaphase / EML4 and NUDC in mitotic spindle formation / Separation of Sister Chromatids / RHO GTPases activate IQGAPs / RHO GTPases Activate Formins / Recruitment of NuMA to mitotic centrosomes / HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand / MHC class II antigen presentation / microtubule depolymerization / COPI-mediated anterograde transport / regulation of microtubule polymerization or depolymerization / tubulin binding / spindle microtubule / Hydrolases; Acting on acid anhydrides; Acting on GTP to facilitate cellular and subcellular movement / protein modification process / structural constituent of cytoskeleton / microtubule cytoskeleton organization / microtubule cytoskeleton / neuron projection development / mitotic cell cycle / growth cone / microtubule / neuron projection / GTPase activity / nucleotide binding / GTP binding / Golgi apparatus / metal ion binding / cytoplasm Similarity search - Function | ||||||
Biological species | Homo sapiens (human) Gallus gallus (chicken) Sus scrofa (pig) | ||||||
Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.304 Å | ||||||
Authors | Kumar, G. / Wang, Y. / Li, W. / White, S.W. | ||||||
Funding support | United States, 1items
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Citation | Journal: J. Med. Chem. / Year: 2018 Title: Heterocyclic-Fused Pyrimidines as Novel Tubulin Polymerization Inhibitors Targeting the Colchicine Binding Site: Structural Basis and Antitumor Efficacy. Authors: Banerjee, S. / Arnst, K.E. / Wang, Y. / Kumar, G. / Deng, S. / Yang, L. / Li, G.B. / Yang, J. / White, S.W. / Li, W. / Miller, D.D. | ||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 6br1.cif.gz | 922.2 KB | Display | PDBx/mmCIF format |
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PDB format | pdb6br1.ent.gz | 753.1 KB | Display | PDB format |
PDBx/mmJSON format | 6br1.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Summary document | 6br1_validation.pdf.gz | 2.6 MB | Display | wwPDB validaton report |
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Full document | 6br1_full_validation.pdf.gz | 2.7 MB | Display | |
Data in XML | 6br1_validation.xml.gz | 86.7 KB | Display | |
Data in CIF | 6br1_validation.cif.gz | 118.7 KB | Display | |
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/br/6br1 ftp://data.pdbj.org/pub/pdb/validation_reports/br/6br1 | HTTPS FTP |
-Related structure data
-Links
-Assembly
Deposited unit |
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Unit cell |
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments:
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