Entry Database : PDB / ID : 3v64 Structure visualization Downloads & linksTitle Crystal Structure of agrin and LRP4 ComponentsLow-density lipoprotein receptor-related protein 4 agrin DetailsKeywords PROTEIN BINDING / beta propeller / laminin-G / signalingFunction / homology Function and homology informationFunction Domain/homology Component
negative regulation of sodium ion export across plasma membrane / A tetrasaccharide linker sequence is required for GAG synthesis / HS-GAG biosynthesis / HS-GAG degradation / positive regulation of presynaptic membrane organization / positive regulation of protein geranylgeranylation / ECM proteoglycans / acetylcholine receptor regulator activity / regulation of axon guidance / regulation of synaptic activity ... negative regulation of sodium ion export across plasma membrane / A tetrasaccharide linker sequence is required for GAG synthesis / HS-GAG biosynthesis / HS-GAG degradation / positive regulation of presynaptic membrane organization / positive regulation of protein geranylgeranylation / ECM proteoglycans / acetylcholine receptor regulator activity / regulation of axon guidance / regulation of synaptic activity / Retinoid metabolism and transport / positive regulation of synaptic assembly at neuromuscular junction / postsynaptic membrane assembly / positive regulation of motor neuron apoptotic process / skeletal muscle acetylcholine-gated channel clustering / chondroitin sulfate binding / regulation of cardiac muscle cell membrane potential / BMP binding / presynaptic membrane assembly / sialic acid binding / plasma membrane organization / negative regulation of axonogenesis / proximal/distal pattern formation / positive regulation of skeletal muscle acetylcholine-gated channel clustering / dystroglycan binding / amyloid-beta clearance by cellular catabolic process / ATPase inhibitor activity / heparan sulfate proteoglycan binding / anatomical structure development / transforming growth factor beta binding / negative regulation of ossification / synaptic assembly at neuromuscular junction / dorsal/ventral pattern formation / embryonic limb morphogenesis / dendrite morphogenesis / limb development / motor neuron apoptotic process / positive regulation of filopodium assembly / generation of neurons / embryonic digit morphogenesis / neuromuscular junction development / regulation of synapse organization / receptor clustering / enzyme-linked receptor protein signaling pathway / odontogenesis of dentin-containing tooth / positive regulation of Rac protein signal transduction / plasma membrane raft / apolipoprotein binding / basement membrane / hair follicle development / regulation of cardiac muscle contraction / synaptic cleft / coreceptor activity / axonal growth cone / regulation of microtubule cytoskeleton organization / synapse assembly / synaptic membrane / kidney development / synapse organization / regulation of protein phosphorylation / negative regulation of canonical Wnt signaling pathway / sarcolemma / neuromuscular junction / protein localization / receptor tyrosine kinase binding / Wnt signaling pathway / positive regulation of GTPase activity / endocytosis / positive regulation of peptidyl-tyrosine phosphorylation / protein transport / chemical synaptic transmission / scaffold protein binding / collagen-containing extracellular matrix / transmembrane transporter binding / postsynaptic density / cell differentiation / receptor ligand activity / positive regulation of protein phosphorylation / dendrite / neuronal cell body / glutamatergic synapse / synapse / calcium ion binding / cell surface / protein homodimerization activity / positive regulation of transcription by RNA polymerase II / extracellular space / extracellular region / plasma membrane Similarity search - Function Follistatin-like, N-terminal / Follistatin-N-terminal domain-like / Factor I / membrane attack complex / factor I membrane attack complex / Complement Clr-like EGF domain / Domain found in sea urchin sperm protein, enterokinase, agrin / Laminin-type EGF-like (LE) domain profile. / Laminin G domain / Laminin-type EGF-like (LE) domain signature. / Laminin-type epidermal growth factor-like domai ... Follistatin-like, N-terminal / Follistatin-N-terminal domain-like / Factor I / membrane attack complex / factor I membrane attack complex / Complement Clr-like EGF domain / Domain found in sea urchin sperm protein, enterokinase, agrin / Laminin-type EGF-like (LE) domain profile. / Laminin G domain / Laminin-type EGF-like (LE) domain signature. / Laminin-type epidermal growth factor-like domai / Laminin EGF domain / Complement Clr-like EGF-like / Kazal-type serine protease inhibitor domain / SEA domain superfamily / Laminin-type EGF domain / SEA domain profile. / Kazal-type serine protease inhibitor domain / SEA domain / SEA domain / Low-density lipoprotein receptor repeat class B / LDL-receptor class B (LDLRB) repeat profile. / Laminin G domain profile. / LDLR class B repeat / Low-density lipoprotein-receptor YWTD domain / Kazal type serine protease inhibitors / TolB, C-terminal domain / Laminin G domain / Laminin G domain / Kazal domain superfamily / Kazal domain / Kazal domain profile. / Low-density lipoprotein receptor domain class A / Low-density lipoprotein (LDL) receptor class A, conserved site / LDL-receptor class A (LDLRA) domain signature. / LDL-receptor class A (LDLRA) domain profile. / Low-density lipoprotein receptor domain class A / Low-density lipoprotein (LDL) receptor class A repeat / LDL receptor-like superfamily / Six-bladed beta-propeller, TolB-like / Coagulation Factor Xa inhibitory site / Laminin / Laminin / EGF-like domain / EGF-like calcium-binding, conserved site / Calcium-binding EGF-like domain signature. / Aspartic acid and asparagine hydroxylation site. / 6 Propeller / Neuraminidase / EGF-like calcium-binding domain / Calcium-binding EGF-like domain / Epidermal growth factor-like domain. / Jelly Rolls - #200 / EGF-like domain profile. / Growth factor receptor cysteine-rich domain superfamily / EGF-like domain signature 2. / EGF-like domain signature 1. / EGF-like domain / Ribbon / Concanavalin A-like lectin/glucanase domain superfamily / Jelly Rolls / Sandwich / Mainly Beta Similarity search - Domain/homologyBiological species Rattus norvegicus (Norway rat)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.85 Å DetailsAuthors Zong, Y. / Zhang, B. / Gu, S. / Lee, K. / Zhou, J. / Yao, G. / Figueiedo, D. / Perry, K. / Mei, L. / Jin, R. CitationJournal : Genes Dev. / Year : 2012Title : Structural basis of agrin-LRP4-MuSK signaling.Authors : Zong, Y. / Zhang, B. / Gu, S. / Lee, K. / Zhou, J. / Yao, G. / Figueiredo, D. / Perry, K. / Mei, L. / Jin, R. History Deposition Dec 18, 2011 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Apr 25, 2012 Provider : repository / Type : Initial releaseRevision 1.1 Mar 1, 2017 Group : Structure summaryRevision 1.2 Jul 29, 2020 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Structure summary Category : chem_comp / entity ... chem_comp / entity / pdbx_chem_comp_identifier / pdbx_entity_nonpoly / pdbx_struct_conn_angle / struct_conn / struct_ref_seq_dif / struct_site / struct_site_gen Item : _chem_comp.name / _chem_comp.type ... _chem_comp.name / _chem_comp.type / _entity.pdbx_description / _pdbx_entity_nonpoly.name / _pdbx_struct_conn_angle.ptnr1_auth_asym_id / _pdbx_struct_conn_angle.ptnr1_auth_comp_id / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr1_label_asym_id / _pdbx_struct_conn_angle.ptnr1_label_atom_id / _pdbx_struct_conn_angle.ptnr1_label_comp_id / _pdbx_struct_conn_angle.ptnr1_label_seq_id / _pdbx_struct_conn_angle.ptnr2_auth_asym_id / _pdbx_struct_conn_angle.ptnr2_auth_seq_id / _pdbx_struct_conn_angle.ptnr2_label_asym_id / _pdbx_struct_conn_angle.ptnr3_auth_asym_id / _pdbx_struct_conn_angle.ptnr3_auth_comp_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_label_asym_id / _pdbx_struct_conn_angle.ptnr3_label_atom_id / _pdbx_struct_conn_angle.ptnr3_label_comp_id / _pdbx_struct_conn_angle.ptnr3_label_seq_id / _pdbx_struct_conn_angle.value / _struct_conn.pdbx_dist_value / _struct_conn.pdbx_leaving_atom_flag / _struct_conn.pdbx_role / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_ref_seq_dif.details Description : Carbohydrate remediation / Provider : repository / Type : Remediation
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