positive regulation of lymphocyte apoptotic process / positive regulation of establishment of protein localization to mitochondrion / lymphocyte apoptotic process / negative regulation of growth / positive regulation of fibroblast apoptotic process / T cell apoptotic process / positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway / positive regulation of T cell apoptotic process / positive regulation of cysteine-type endopeptidase activity / mitochondrial envelope ...positive regulation of lymphocyte apoptotic process / positive regulation of establishment of protein localization to mitochondrion / lymphocyte apoptotic process / negative regulation of growth / positive regulation of fibroblast apoptotic process / T cell apoptotic process / positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway / positive regulation of T cell apoptotic process / positive regulation of cysteine-type endopeptidase activity / mitochondrial envelope / positive regulation of thymocyte apoptotic process / channel activity / fibroblast apoptotic process / mitochondrial fusion / Bcl-2 family protein complex / BH domain binding / execution phase of apoptosis / BH3 domain binding / positive regulation of release of cytochrome c from mitochondria / intrinsic apoptotic signaling pathway by p53 class mediator / negative regulation of anoikis / negative regulation of extrinsic apoptotic signaling pathway in absence of ligand / intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress / intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator / positive regulation of intrinsic apoptotic signaling pathway / extrinsic apoptotic signaling pathway in absence of ligand / response to endoplasmic reticulum stress / negative regulation of autophagy / release of cytochrome c from mitochondria / response to cytokine / determination of adult lifespan / cellular response to ionizing radiation / apoptotic signaling pathway / positive regulation of protein-containing complex assembly / negative regulation of cell growth / activation of cysteine-type endopeptidase activity involved in apoptotic process / intrinsic apoptotic signaling pathway in response to DNA damage / positive regulation of neuron apoptotic process / cellular response to hypoxia / regulation of apoptotic process / mitochondrial outer membrane / cell differentiation / protein dimerization activity / protein heterodimerization activity / positive regulation of apoptotic process / DNA damage response / negative regulation of apoptotic process / protein-containing complex binding / mitochondrion / nucleoplasm / membrane / nucleus / cytoplasm / cytosol Similarity search - Function
Bcl-2-binding component 3 / Bcl-2-binding component 3, p53 upregulated modulator of apoptosis / Apoptosis regulator, Mcl-1 / Blc2-like / Apoptosis Regulator Bcl-x / Apoptosis regulator, Bcl-2, BH3 motif, conserved site / Apoptosis regulator, Bcl-2 family BH3 motif signature. / Apoptosis regulator, Bcl-2, BH1 motif, conserved site / Apoptosis regulator, Bcl-2 family BH1 motif signature. / Apoptosis regulator, Bcl-2, BH2 motif, conserved site ...Bcl-2-binding component 3 / Bcl-2-binding component 3, p53 upregulated modulator of apoptosis / Apoptosis regulator, Mcl-1 / Blc2-like / Apoptosis Regulator Bcl-x / Apoptosis regulator, Bcl-2, BH3 motif, conserved site / Apoptosis regulator, Bcl-2 family BH3 motif signature. / Apoptosis regulator, Bcl-2, BH1 motif, conserved site / Apoptosis regulator, Bcl-2 family BH1 motif signature. / Apoptosis regulator, Bcl-2, BH2 motif, conserved site / Apoptosis regulator, Bcl-2 family BH2 motif signature. / BCL (B-Cell lymphoma); contains BH1, BH2 regions / Bcl-2 family / Bcl-2, Bcl-2 homology region 1-3 / Bcl2-like / Apoptosis regulator proteins, Bcl-2 family / BCL2-like apoptosis inhibitors family profile. / Bcl-2-like superfamily / Orthogonal Bundle / Mainly Alpha Similarity search - Domain/homology
Ionic strength: 120 mM / pH: 6.7 / Pressure: ambient / Temperature: 298 K
-
NMR measurement
NMR spectrometer
Type
Manufacturer
Model
Field strength (MHz)
Spectrometer-ID
Bruker Avance
Bruker
AVANCE
500
1
Bruker DRX
Bruker
DRX
600
2
Bruker Avance
Bruker
AVANCE
800
3
-
Processing
NMR software
Name
Version
Developer
Classification
TopSpin
1.3
BrukerBiospin
collection
XEASY
1.3
Bartelsetal.
dataanalysis
CYANA
2.1
Guntert, MumenthalerandWuthrich
structuresolution
X-PLOR NIH
Schwieters, Kuszewski, TjandraandClore
refinement
Refinement
Method: DGSA-distance geometry simulated annealing / Software ordinal: 1 Details: Structures were calculated on the basis of 3667 total constraints. 2943 of these constraints were NOE-derived distances of which 197 were intermolecular NOEs; 348 dihedral angle restraints and 188 hydrogen bonds
NMR constraints
NOE constraints total: 2943 / NOE intraresidue total count: 788 / NOE long range total count: 953 / NOE medium range total count: 591 / NOE sequential total count: 611 / Hydrogen bond constraints total count: 376 / Protein phi angle constraints total count: 174 / Protein psi angle constraints total count: 174
NMR representative
Selection criteria: closest to the average
NMR ensemble
Conformer selection criteria: structures with the least restraint violations Conformers calculated total number: 256 / Conformers submitted total number: 20 / Maximum torsion angle constraint violation: 5 ° / Maximum upper distance constraint violation: 0.2 Å
NMR ensemble rms
Distance rms dev: 0.01 Å / Distance rms dev error: 0.0009 Å
+
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