[English] 日本語
Yorodumi- PDB-1tce: SOLUTION NMR STRUCTURE OF THE SHC SH2 DOMAIN COMPLEXED WITH A TYR... -
+Open data
-Basic information
Entry | Database: PDB / ID: 1tce | ||||||
---|---|---|---|---|---|---|---|
Title | SOLUTION NMR STRUCTURE OF THE SHC SH2 DOMAIN COMPLEXED WITH A TYROSINE-PHOSPHORYLATED PEPTIDE FROM THE T-CELL RECEPTOR, MINIMIZED AVERAGE STRUCTURE | ||||||
Components |
| ||||||
Keywords | COMPLEX (SIGNAL TRANSDUCTION/PEPTIDE) / SH2 DOMAIN / COMPLEX (SIGNAL TRANSDUCTION-PEPTIDE) / COMPLEX (SIGNAL TRANSDUCTION-PEPTIDE) complex | ||||||
Function / homology | Function and homology information Shc-EGFR complex / regulation of superoxide metabolic process / epidermal growth factor binding / gamma-delta T cell receptor complex / positive regulation of cell proliferation in bone marrow / Fc-gamma receptor III complex / gamma-delta T cell activation / Fc-gamma receptor signaling pathway / XBP1(S) activates chaperone genes / neurotrophin TRKA receptor binding ...Shc-EGFR complex / regulation of superoxide metabolic process / epidermal growth factor binding / gamma-delta T cell receptor complex / positive regulation of cell proliferation in bone marrow / Fc-gamma receptor III complex / gamma-delta T cell activation / Fc-gamma receptor signaling pathway / XBP1(S) activates chaperone genes / neurotrophin TRKA receptor binding / alpha-beta T cell receptor complex / positive regulation of protein localization to cell surface / transmembrane receptor protein tyrosine kinase adaptor activity / Nef and signal transduction / Interleukin-15 signaling / Interleukin-2 signaling / Signaling by LTK / T cell receptor complex / epidermal growth factor receptor binding / Signaling by ALK / Translocation of ZAP-70 to Immunological synapse / Phosphorylation of CD3 and TCR zeta chains / alpha-beta T cell activation / Generation of second messenger molecules / RET signaling / Activated NTRK3 signals through RAS / Activated NTRK2 signals through RAS / FCGR activation / Interleukin-3, Interleukin-5 and GM-CSF signaling / SHC1 events in ERBB4 signaling / SHC1 events in EGFR signaling / PD-1 signaling / Signalling to RAS / Role of phospholipids in phagocytosis / SHC-related events triggered by IGF1R / Role of LAT2/NTAL/LAB on calcium mobilization / Interleukin receptor SHC signaling / Signal attenuation / SHC1 events in ERBB2 signaling / SHC-mediated cascade:FGFR3 / MET activates RAS signaling / negative regulation of angiogenesis / SHC-mediated cascade:FGFR2 / SHC-mediated cascade:FGFR4 / Erythropoietin activates RAS / SHC-mediated cascade:FGFR1 / Signaling by CSF3 (G-CSF) / Tie2 Signaling / insulin-like growth factor receptor binding / ephrin receptor binding / phosphotyrosine residue binding / Integrin signaling / Constitutive Signaling by Overexpressed ERBB2 / FCERI mediated Ca+2 mobilization / Insulin receptor signalling cascade / FCGR3A-mediated IL10 synthesis / protein tyrosine kinase binding / insulin-like growth factor receptor signaling pathway / Signaling by ERBB2 TMD/JMD mutants / Constitutive Signaling by EGFRvIII / Signaling by ERBB2 ECD mutants / Signaling by ERBB2 KD Mutants / epidermal growth factor receptor signaling pathway / FCERI mediated MAPK activation / FCGR3A-mediated phagocytosis / cell-cell adhesion / insulin receptor binding / transmembrane signaling receptor activity / phospholipid binding / Regulation of actin dynamics for phagocytic cup formation / receptor tyrosine kinase binding / cellular response to growth factor stimulus / Signaling by CSF1 (M-CSF) in myeloid cells / GPER1 signaling / Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell / Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants / Signaling by ALK fusions and activated point mutants / Downstream TCR signaling / insulin receptor signaling pathway / DAP12 signaling / protein complex oligomerization / heart development / RAF/MAP kinase cascade / T cell receptor signaling pathway / actin cytoskeleton organization / protein-containing complex assembly / angiogenesis / adaptive immune response / Extra-nuclear estrogen signaling / positive regulation of ERK1 and ERK2 cascade / positive regulation of MAPK cascade / cell surface receptor signaling pathway / intracellular signal transduction / mitochondrial matrix / defense response to bacterium / protein heterodimerization activity / focal adhesion / negative regulation of DNA-templated transcription / positive regulation of cell population proliferation / positive regulation of DNA-templated transcription Similarity search - Function | ||||||
Biological species | Homo sapiens (human) | ||||||
Method | SOLUTION NMR | ||||||
Authors | Zhou, M.-M. / Meadows, R.P. / Logan, T.M. / Yoon, H.S. / Wade, W.R. / Ravichandran, K.S. / Burakoff, S.J. / Feisk, S.W. | ||||||
Citation | Journal: Proc.Natl.Acad.Sci.USA / Year: 1995 Title: Solution structure of the Shc SH2 domain complexed with a tyrosine-phosphorylated peptide from the T-cell receptor. Authors: Zhou, M.M. / Meadows, R.P. / Logan, T.M. / Yoon, H.S. / Wade, W.S. / Ravichandran, K.S. / Burakoff, S.J. / Fesik, S.W. #1: Journal: Cell(Cambridge,Mass.) / Year: 1994 Title: Nuclear Magnetic Resonance Structure of an Sh2 Domain of Phospholipase C-Gamma 1 Complexed with a High Affinity Binding Peptide Authors: Pascal, S.M. / Singer, A.U. / Gish, G. / Yamazaki, T. / Shoelson, S.E. / Pawson, T. / Kay, L.E. / Forman-Kay, J.D. #2: Journal: Cell(Cambridge,Mass.) / Year: 1993 Title: Binding of a High Affinity Phosphotyrosyl Peptide to the Src Sh2 Domain: Crystal Structures of the Complexed and Peptide-Free Forms Authors: Waksman, G. / Shoelson, S.E. / Pant, N. / Cowburn, D. / Kuriyan, J. #3: Journal: Nature / Year: 1993 Title: Recognition of a High-Affinity Phosphotyrosyl Peptide by the Src Homology-2 Domain of P56Lck Authors: Eck, M.J. / Shoelson, S.E. / Harrison, S.C. | ||||||
History |
|
-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
---|
-Downloads & links
-Download
PDBx/mmCIF format | 1tce.cif.gz | 50.3 KB | Display | PDBx/mmCIF format |
---|---|---|---|---|
PDB format | pdb1tce.ent.gz | 39.8 KB | Display | PDB format |
PDBx/mmJSON format | 1tce.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Summary document | 1tce_validation.pdf.gz | 259.6 KB | Display | wwPDB validaton report |
---|---|---|---|---|
Full document | 1tce_full_validation.pdf.gz | 259.4 KB | Display | |
Data in XML | 1tce_validation.xml.gz | 4.8 KB | Display | |
Data in CIF | 1tce_validation.cif.gz | 6.1 KB | Display | |
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/tc/1tce ftp://data.pdbj.org/pub/pdb/validation_reports/tc/1tce | HTTPS FTP |
-Related structure data
Similar structure data |
---|
-Links
-Assembly
Deposited unit |
| |||||||||
---|---|---|---|---|---|---|---|---|---|---|
1 |
| |||||||||
NMR ensembles |
|
-Components
#1: Protein | Mass: 12123.677 Da / Num. of mol.: 1 / Fragment: SH2 DOMAIN Source method: isolated from a genetically manipulated source Source: (gene. exp.) Homo sapiens (human) / Strain: BL21 (DE3) / Cell line: BL21 / Gene: SH2 DOMAIN OF SHC / Plasmid: PET20B / Gene (production host): SH2 DOMAIN OF SHC / Production host: Escherichia coli (E. coli) / References: UniProt: P29353 |
---|---|
#2: Protein/peptide | Mass: 1529.545 Da / Num. of mol.: 1 Source method: isolated from a genetically manipulated source References: UniProt: P20963 |
-Experimental details
-Experiment
Experiment | Method: SOLUTION NMR |
---|
-Sample preparation
Crystal grow | *PLUS Method: other / Details: NMR |
---|
-Processing
Software |
| ||||||||
---|---|---|---|---|---|---|---|---|---|
NMR software | Name: X-PLOR / Developer: BRUNGER / Classification: refinement | ||||||||
Refinement | Software ordinal: 1 Details: SET OF IDEAL BOND LENGTHS AND ANGLES USED DURING REFINEMENT: PARALLHDG.PRO IN X-PLOR. | ||||||||
NMR ensemble | Conformers submitted total number: 1 |