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Yorodumi- PDB-1qg1: GROWTH FACTOR RECEPTOR BINDING PROTEIN SH2 DOMAIN COMPLEXED WITH ... -
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-Basic information
Entry | Database: PDB / ID: 1qg1 | ||||||
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Title | GROWTH FACTOR RECEPTOR BINDING PROTEIN SH2 DOMAIN COMPLEXED WITH AN SHC-DERIVED PEPTIDE | ||||||
Components |
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Keywords | HORMONE/GROWTH FACTOR / SIGNAL TRANSDUCTION / SH2 DOMAIN / PHOSPHOTYROSYL PEPTIDE / COMPLEX (SIGNAL TRANSDUCTION-PEPTIDE) / HORMONE-GROWTH FACTOR COMPLEX | ||||||
Function / homology | Function and homology information regulation of superoxide metabolic process / positive regulation of cell proliferation in bone marrow / guanyl-nucleotide exchange factor adaptor activity / Grb2-EGFR complex / branching involved in labyrinthine layer morphogenesis / XBP1(S) activates chaperone genes / STAT5 Activation / COP9 signalosome / vesicle membrane / neurotrophin TRKA receptor binding ...regulation of superoxide metabolic process / positive regulation of cell proliferation in bone marrow / guanyl-nucleotide exchange factor adaptor activity / Grb2-EGFR complex / branching involved in labyrinthine layer morphogenesis / XBP1(S) activates chaperone genes / STAT5 Activation / COP9 signalosome / vesicle membrane / neurotrophin TRKA receptor binding / Activated NTRK2 signals through PI3K / MET receptor recycling / transmembrane receptor protein tyrosine kinase adaptor activity / Signaling by cytosolic FGFR1 fusion mutants / Interleukin-15 signaling / MET activates PTPN11 / MET activates RAP1 and RAC1 / Shc-EGFR complex / Interleukin-2 signaling / CD28 dependent Vav1 pathway / Costimulation by the CD28 family / MET activates PI3K/AKT signaling / epidermal growth factor binding / Signal regulatory protein family interactions / Regulation of KIT signaling / epidermal growth factor receptor binding / Signaling by ALK / positive regulation of actin filament polymerization / PI-3K cascade:FGFR3 / STAT5 activation downstream of FLT3 ITD mutants / PI-3K cascade:FGFR2 / PI-3K cascade:FGFR4 / PI-3K cascade:FGFR1 / endodermal cell differentiation / regulation of MAPK cascade / GRB2:SOS provides linkage to MAPK signaling for Integrins / RHOU GTPase cycle / PI3K events in ERBB2 signaling / Signaling by ALK fusions and activated point mutants / SOS-mediated signalling / Activated NTRK3 signals through RAS / RET signaling / Activated NTRK2 signals through RAS / insulin receptor substrate binding / PI3K Cascade / Interleukin-3, Interleukin-5 and GM-CSF signaling / SHC1 events in ERBB4 signaling / RHO GTPases Activate WASPs and WAVEs / Signalling to RAS / fibroblast growth factor receptor signaling pathway / GAB1 signalosome / SHC-related events triggered by IGF1R / Activated NTRK2 signals through FRS2 and FRS3 / Role of LAT2/NTAL/LAB on calcium mobilization / Signal attenuation / Interleukin receptor SHC signaling / SHC-mediated cascade:FGFR3 / MET activates RAS signaling / Schwann cell development / Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants / Signaling by PDGFRA extracellular domain mutants / SHC-mediated cascade:FGFR2 / SHC-mediated cascade:FGFR4 / Signaling by FGFR4 in disease / SHC-mediated cascade:FGFR1 / Erythropoietin activates RAS / signal transduction in response to DNA damage / FRS-mediated FGFR3 signaling / Signaling by CSF3 (G-CSF) / Signaling by FLT3 ITD and TKD mutants / FRS-mediated FGFR2 signaling / FRS-mediated FGFR4 signaling / Signaling by FGFR3 in disease / FRS-mediated FGFR1 signaling / Tie2 Signaling / Signaling by FGFR2 in disease / GRB2 events in EGFR signaling / insulin-like growth factor receptor binding / SHC1 events in EGFR signaling / myelination / EGFR Transactivation by Gastrin / Signaling by FLT3 fusion proteins / FLT3 Signaling / Signaling by FGFR1 in disease / GRB2 events in ERBB2 signaling / NCAM signaling for neurite out-growth / phosphotyrosine residue binding / ephrin receptor binding / SHC1 events in ERBB2 signaling / Integrin signaling / Downstream signal transduction / Insulin receptor signalling cascade / Constitutive Signaling by Overexpressed ERBB2 / negative regulation of angiogenesis / FCERI mediated Ca+2 mobilization / InlB-mediated entry of Listeria monocytogenes into host cell / insulin-like growth factor receptor signaling pathway / Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants / Antigen activates B Cell Receptor (BCR) leading to generation of second messengers / cellular response to ionizing radiation Similarity search - Function | ||||||
Biological species | Homo sapiens (human) | ||||||
Method | SOLUTION NMR | ||||||
Authors | Ogura, K. | ||||||
Citation | Journal: J.Mol.Biol. / Year: 1999 Title: Solution structure of the SH2 domain of Grb2 complexed with the Shc-derived phosphotyrosine-containing peptide. Authors: Ogura, K. / Tsuchiya, S. / Terasawa, H. / Yuzawa, S. / Hatanaka, H. / Mandiyan, V. / Schlessinger, J. / Inagaki, F. | ||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 1qg1.cif.gz | 49.2 KB | Display | PDBx/mmCIF format |
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PDB format | pdb1qg1.ent.gz | 35 KB | Display | PDB format |
PDBx/mmJSON format | 1qg1.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/qg/1qg1 ftp://data.pdbj.org/pub/pdb/validation_reports/qg/1qg1 | HTTPS FTP |
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-Related structure data
Similar structure data |
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-Links
-Assembly
Deposited unit |
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1 |
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NMR ensembles |
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-Components
#1: Protein | Mass: 12012.516 Da / Num. of mol.: 1 / Fragment: SH2 Source method: isolated from a genetically manipulated source Details: RESIDUES HIS-58 - THR-159 AND THE EXTRINSIC N-TERMINAL TWO RESIDUES, GLY-56 AND SER-57 Source: (gene. exp.) Homo sapiens (human) / Plasmid: BL21 (DE3) Gene (production host): PROTEIN WAS EXPRESSED WITH PGEX-4T-2 VECTOR AND BL21 (DE3) CELL AS GST-FUSION PROTEIN, AND CLEAVED WITH TRYPSIN Production host: Escherichia coli (E. coli) / References: UniProt: P62993 |
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#2: Protein/peptide | Mass: 1587.558 Da / Num. of mol.: 1 / Fragment: 423-435 / Source method: obtained synthetically Details: THE PEPTIDE WAS CHEMICALLY SYNTHESIZED BY THE SOLID-PHASE FMOC STRATEGY. THE SEQUENCE OF THIS PEPTIDE IS NATURALLY FOUND IN HOMO SAPIENS (HUMAN). References: UniProt: P29353 |
-Experimental details
-Experiment
Experiment | Method: SOLUTION NMR |
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NMR details | Text: MEAN STRUCTURE. NULL |
-Sample preparation
Sample conditions | pH: 6.3 / Temperature: 301 K |
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Crystal grow | *PLUS Method: other / Details: NMR |
-Processing
NMR software |
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NMR ensemble | Conformer selection criteria: LOWEST ENERGY / Conformers calculated total number: 100 / Conformers submitted total number: 1 |