Entry Database : PDB / ID : 1ivo Structure visualization Downloads & linksTitle Crystal Structure of the Complex of Human Epidermal Growth Factor and Receptor Extracellular Domains. ComponentsEpidermal Growth Factor Receptor Epidermal growth factor DetailsKeywords TRANSFERASE/SIGNALING PROTEIN / Transmembrane / Glycoprotein / Receptor / RIKEN Structural Genomics/Proteomics Initiative / RSGI / Structural Genomics / TRANSFERASE-SIGNALING PROTEIN COMPLEXFunction / homology Function and homology informationFunction Domain/homology Component
Inhibition of Signaling by Overexpressed EGFR / EGFR interacts with phospholipase C-gamma / negative regulation of secretion / negative regulation of cholesterol efflux / positive regulation of hyaluronan biosynthetic process / PLCG1 events in ERBB2 signaling / positive regulation of cerebellar granule cell precursor proliferation / cerebellar granule cell precursor proliferation / ERBB2-EGFR signaling pathway / positive regulation of epithelial tube formation ... Inhibition of Signaling by Overexpressed EGFR / EGFR interacts with phospholipase C-gamma / negative regulation of secretion / negative regulation of cholesterol efflux / positive regulation of hyaluronan biosynthetic process / PLCG1 events in ERBB2 signaling / positive regulation of cerebellar granule cell precursor proliferation / cerebellar granule cell precursor proliferation / ERBB2-EGFR signaling pathway / positive regulation of epithelial tube formation / ERBB2 Activates PTK6 Signaling / regulation of calcium ion import / positive regulation of protein localization to early endosome / regulation of protein localization to cell surface / Signaling by EGFR / transmembrane receptor protein tyrosine kinase activator activity / Signaling by ERBB4 / positive regulation of ubiquitin-dependent protein catabolic process / ERBB2 Regulates Cell Motility / Differentiation of keratinocytes in interfollicular epidermis in mammalian skin / PI3K events in ERBB2 signaling / regulation of receptor signaling pathway via JAK-STAT / Estrogen-dependent nuclear events downstream of ESR-membrane signaling / NFE2L2 regulating tumorigenic genes / epidermal growth factor receptor binding / branching morphogenesis of an epithelial tube / positive regulation of DNA binding / GAB1 signalosome / positive regulation of phosphorylation / positive regulation of receptor internalization / Signaling by ERBB2 / GRB2 events in EGFR signaling / SHC1 events in EGFR signaling / Complex I biogenesis / mammary gland alveolus development / GRB2 events in ERBB2 signaling / Respiratory electron transport / SHC1 events in ERBB2 signaling / epithelial cell proliferation / positive regulation of endothelial cell proliferation / ERK1 and ERK2 cascade / NOTCH3 Activation and Transmission of Signal to the Nucleus / positive regulation of endothelial cell migration / positive regulation of mitotic nuclear division / EGFR downregulation / Signaling by ERBB2 TMD/JMD mutants / platelet alpha granule lumen / guanyl-nucleotide exchange factor activity / : / positive regulation of peptidyl-threonine phosphorylation / Constitutive Signaling by EGFRvIII / clathrin-coated endocytic vesicle membrane / mitochondrial electron transport, NADH to ubiquinone / Signaling by ERBB2 ECD mutants / proton motive force-driven mitochondrial ATP synthesis / Signaling by ERBB2 KD Mutants / epidermal growth factor receptor signaling pathway / NADH dehydrogenase (ubiquinone) activity / Downregulation of ERBB2 signaling / growth factor activity / aerobic respiration / Constitutive Signaling by Aberrant PI3K in Cancer / positive regulation of canonical Wnt signaling pathway / Cargo recognition for clathrin-mediated endocytosis / positive regulation of peptidyl-tyrosine phosphorylation / Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants / PIP3 activates AKT signaling / Clathrin-mediated endocytosis / Platelet degranulation / PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling / RAF/MAP kinase cascade / angiogenesis / Extra-nuclear estrogen signaling / positive regulation of MAPK cascade / positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / receptor ligand activity / electron transfer activity / mitochondrial inner membrane / positive regulation of cell migration / lysosomal membrane / positive regulation of cell population proliferation / calcium ion binding / positive regulation of gene expression / positive regulation of DNA-templated transcription / extracellular space / extracellular exosome / extracellular region / plasma membrane Similarity search - Function Pro-epidermal growth factor / 24 nucleotide stem-loop, u2 snrnp hairpin iv. U2 a'; Chain A / Receptor L-domain / : / Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A domain 2 / Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A, domain 2 / Growth factor receptor domain IV / Low-density lipoprotein receptor repeat class B / LDL-receptor class B (LDLRB) repeat profile. / LDLR class B repeat ... Pro-epidermal growth factor / 24 nucleotide stem-loop, u2 snrnp hairpin iv. U2 a'; Chain A / Receptor L-domain / : / Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A domain 2 / Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A, domain 2 / Growth factor receptor domain IV / Low-density lipoprotein receptor repeat class B / LDL-receptor class B (LDLRB) repeat profile. / LDLR class B repeat / Low-density lipoprotein-receptor YWTD domain / : / Calcium-binding EGF domain / Furin-like cysteine rich region / Receptor L domain / Alpha-Beta Horseshoe / Six-bladed beta-propeller, TolB-like / Laminin / Coagulation Factor Xa inhibitory site / Laminin / EGF-like domain / NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial / EGF-type aspartate/asparagine hydroxylation site / EGF-like calcium-binding, conserved site / Zinc finger, CHCC-type / Zinc-finger domain / Calcium-binding EGF-like domain signature. / Aspartic acid and asparagine hydroxylation site. / EGF-like calcium-binding domain / Calcium-binding EGF-like domain / Growth factor receptor cysteine-rich domain superfamily / Epidermal growth factor-like domain. / EGF-like domain profile. / EGF-like domain signature 2. / EGF-like domain signature 1. / EGF-like domain / Ribbon / Mainly Beta / Alpha Beta Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MAD / Resolution : 3.3 Å DetailsAuthors Ogiso, H. / Ishitani, R. / Nureki, O. / Fukai, S. / Yamanaka, M. / Kim, J.H. / Saito, K. / Shirouzu, M. / Yokoyama, S. / RIKEN Structural Genomics/Proteomics Initiative (RSGI) CitationJournal : Cell(Cambridge,Mass.) / Year : 2002Title : Crystal Structure of the Complex of Human Epidermal Growth Factor and Receptor Extracellular Domains.Authors : Ogiso, H. / Ishitani, R. / Nureki, O. / Fukai, S. / Yamanaka, M. / Kim, J.H. / Saito, K. / Inoue, M. / Shirouzu, M. / Yokoyama, S. History Deposition Mar 28, 2002 Deposition site : PDBJ / Processing site : PDBJRevision 1.0 Oct 16, 2002 Provider : repository / Type : Initial releaseRevision 1.1 Apr 27, 2008 Group : Version format complianceRevision 1.2 Jul 13, 2011 Group : Non-polymer description / Version format complianceRevision 2.0 Jul 29, 2020 Group : Advisory / Atomic model ... Advisory / Atomic model / Data collection / Derived calculations / Structure summary Category : atom_site / chem_comp ... atom_site / chem_comp / entity / pdbx_branch_scheme / pdbx_chem_comp_identifier / pdbx_entity_branch / pdbx_entity_branch_descriptor / pdbx_entity_branch_link / pdbx_entity_branch_list / pdbx_entity_nonpoly / pdbx_nonpoly_scheme / pdbx_struct_assembly_gen / pdbx_unobs_or_zero_occ_residues / struct_asym / struct_conn / struct_site / struct_site_gen Item : _atom_site.B_iso_or_equiv / _atom_site.Cartn_x ... _atom_site.B_iso_or_equiv / _atom_site.Cartn_x / _atom_site.Cartn_y / _atom_site.Cartn_z / _atom_site.auth_asym_id / _atom_site.auth_seq_id / _atom_site.label_asym_id / _atom_site.label_entity_id / _chem_comp.name / _chem_comp.type / _pdbx_entity_nonpoly.entity_id / _pdbx_entity_nonpoly.name / _pdbx_struct_assembly_gen.asym_id_list / _struct_conn.pdbx_leaving_atom_flag / _struct_conn.pdbx_role / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id Description : Carbohydrate remediation / Provider : repository / Type : RemediationRevision 2.1 Dec 27, 2023 Group : Advisory / Data collection ... Advisory / Data collection / Database references / Structure summary Category : chem_comp / chem_comp_atom ... chem_comp / chem_comp_atom / chem_comp_bond / database_2 / pdbx_unobs_or_zero_occ_residues Item : _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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