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Yorodumi- PDB-1hcn: STRUCTURE OF HUMAN CHORIONIC GONADOTROPIN AT 2.6 ANGSTROMS RESOLU... -
+Open data
-Basic information
Entry | Database: PDB / ID: 1hcn | ||||||
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Title | STRUCTURE OF HUMAN CHORIONIC GONADOTROPIN AT 2.6 ANGSTROMS RESOLUTION FROM MAD ANALYSIS OF THE SELENOMETHIONYL PROTEIN | ||||||
Components | (HUMAN CHORIONIC GONADOTROPIN) x 2 | ||||||
Keywords | HORMONE | ||||||
Function / homology | Function and homology information follicle-stimulating hormone activity / follicle-stimulating hormone complex / pituitary gonadotropin complex / luteinizing hormone secretion / follicle-stimulating hormone secretion / positive regulation of steroid biosynthetic process / Thyroxine biosynthesis / Mineralocorticoid biosynthesis / Hormone ligand-binding receptors / Glycoprotein hormones ...follicle-stimulating hormone activity / follicle-stimulating hormone complex / pituitary gonadotropin complex / luteinizing hormone secretion / follicle-stimulating hormone secretion / positive regulation of steroid biosynthetic process / Thyroxine biosynthesis / Mineralocorticoid biosynthesis / Hormone ligand-binding receptors / Glycoprotein hormones / Reactions specific to the complex N-glycan synthesis pathway / Androgen biosynthesis / follicle-stimulating hormone signaling pathway / female gamete generation / negative regulation of organ growth / thyroid hormone generation / regulation of signaling receptor activity / organ growth / thyroid gland development / TFAP2 (AP-2) family regulates transcription of growth factors and their receptors / hormone-mediated signaling pathway / hormone activity / Golgi lumen / cell-cell signaling / G alpha (s) signalling events / positive regulation of cell migration / G protein-coupled receptor signaling pathway / positive regulation of cell population proliferation / apoptotic process / signal transduction / positive regulation of transcription by RNA polymerase II / extracellular space / extracellular region / cytoplasm Similarity search - Function | ||||||
Biological species | Homo sapiens (human) | ||||||
Method | X-RAY DIFFRACTION / Resolution: 2.6 Å | ||||||
Authors | Wu, H. / Lustbader, J.W. / Liu, Y. / Canfield, R.E. / Hendrickson, W.A. | ||||||
Citation | Journal: Structure / Year: 1994 Title: Structure of human chorionic gonadotropin at 2.6 A resolution from MAD analysis of the selenomethionyl protein. Authors: Wu, H. / Lustbader, J.W. / Liu, Y. / Canfield, R.E. / Hendrickson, W.A. #1: Journal: To be Published Title: The Expression, Characterization and Crystallization of Wild-Type and Selenomethionyl Hcg Authors: Lustbader, J.W. / Wu, H. / Birken, S. / Pollak, S. / Kolks, M.A.G. / Pound, A.M. / Austin, D. / Hendrickson, W.A. / Canfield, R.E. | ||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 1hcn.cif.gz | 48.7 KB | Display | PDBx/mmCIF format |
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PDB format | pdb1hcn.ent.gz | 37.4 KB | Display | PDB format |
PDBx/mmJSON format | 1hcn.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Summary document | 1hcn_validation.pdf.gz | 396.6 KB | Display | wwPDB validaton report |
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Full document | 1hcn_full_validation.pdf.gz | 407.1 KB | Display | |
Data in XML | 1hcn_validation.xml.gz | 7.1 KB | Display | |
Data in CIF | 1hcn_validation.cif.gz | 10.1 KB | Display | |
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/hc/1hcn ftp://data.pdbj.org/pub/pdb/validation_reports/hc/1hcn | HTTPS FTP |
-Related structure data
Similar structure data |
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-Links
-Assembly
Deposited unit |
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1 |
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2 |
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Unit cell |
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Atom site foot note | 1: CIS PROLINE - PRO B 50 |
-Components
#1: Protein | Mass: 10217.769 Da / Num. of mol.: 1 Source method: isolated from a genetically manipulated source Source: (gene. exp.) Homo sapiens (human) / References: UniProt: P01215 | ||
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#2: Protein | Mass: 15548.979 Da / Num. of mol.: 1 Source method: isolated from a genetically manipulated source References: UniProt: P01233, UniProt: P0DN86*PLUS | ||
#3: Sugar | #4: Water | ChemComp-HOH / | |
-Experimental details
-Experiment
Experiment | Method: X-RAY DIFFRACTION |
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-Sample preparation
Crystal | Density Matthews: 3.6 Å3/Da / Density % sol: 65.84 % |
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-Data collection
Radiation | Scattering type: x-ray |
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Radiation wavelength | Relative weight: 1 |
-Processing
Software |
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Refinement | Resolution: 2.6→5 Å / σ(F): 3 Details: HOH 301 MIGHT BE SO4, BUT NO ATTEMPT WAS MADE TO MODEL IT AS S04.
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Refinement step | Cycle: LAST / Resolution: 2.6→5 Å
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Refine LS restraints |
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Refinement | *PLUS Rfactor obs: 0.199 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Solvent computation | *PLUS | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Displacement parameters | *PLUS | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Refine LS restraints | *PLUS
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