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Yorodumi- PDB-1cyl: ASPECTS OF RECEPTOR BINDING AND SIGNALLING OF INTERLEUKIN-4 INVES... -
+Open data
-Basic information
Entry | Database: PDB / ID: 1cyl | ||||||
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Title | ASPECTS OF RECEPTOR BINDING AND SIGNALLING OF INTERLEUKIN-4 INVESTIGATED BY SITE-DIRECTED MUTAGENESIS AND NMR SPECTROSCOPY | ||||||
Components | INTERLEUKIN-4 | ||||||
Keywords | CYTOKINE | ||||||
Function / homology | Function and homology information interleukin-4 receptor binding / positive regulation of isotype switching to IgE isotypes / negative regulation of cellular response to transforming growth factor beta stimulus / negative regulation of complement-dependent cytotoxicity / positive regulation of cellular respiration / regulation of isotype switching / Interleukin-18 signaling / negative regulation of neuroinflammatory response / negative regulation of epithelial cell migration / positive regulation of T-helper 2 cell cytokine production ...interleukin-4 receptor binding / positive regulation of isotype switching to IgE isotypes / negative regulation of cellular response to transforming growth factor beta stimulus / negative regulation of complement-dependent cytotoxicity / positive regulation of cellular respiration / regulation of isotype switching / Interleukin-18 signaling / negative regulation of neuroinflammatory response / negative regulation of epithelial cell migration / positive regulation of T-helper 2 cell cytokine production / dendritic cell differentiation / positive regulation of isotype switching to IgG isotypes / neuroinflammatory response / interleukin-4-mediated signaling pathway / macrophage activation / positive regulation of interleukin-13 production / myeloid dendritic cell differentiation / positive regulation of amyloid-beta clearance / regulation of phosphorylation / type 2 immune response / activation of Janus kinase activity / positive regulation of MHC class II biosynthetic process / positive regulation of T cell differentiation / positive regulation of ATP biosynthetic process / negative regulation of osteoclast differentiation / positive regulation of interleukin-10 production / positive regulation of macroautophagy / negative regulation of tumor necrosis factor production / regulation of immune response / negative regulation of endothelial cell apoptotic process / positive regulation of T cell proliferation / positive regulation of B cell proliferation / positive regulation of tyrosine phosphorylation of STAT protein / T cell activation / cholesterol metabolic process / B cell differentiation / cytokine activity / negative regulation of inflammatory response / growth factor activity / positive regulation of receptor-mediated endocytosis / positive regulation of cold-induced thermogenesis / Interleukin-4 and Interleukin-13 signaling / positive regulation of cell migration / immune response / negative regulation of DNA-templated transcription / positive regulation of cell population proliferation / positive regulation of gene expression / positive regulation of DNA-templated transcription / negative regulation of apoptotic process / negative regulation of transcription by RNA polymerase II / positive regulation of transcription by RNA polymerase II / extracellular space / extracellular region Similarity search - Function | ||||||
Biological species | Homo sapiens (human) | ||||||
Method | SOLUTION NMR | ||||||
Authors | Mueller, T. / Sebald, W. / Oschkinat, H. | ||||||
Citation | Journal: J.Mol.Biol. / Year: 1994 Title: Aspects of receptor binding and signalling of interleukin-4 investigated by site-directed mutagenesis and NMR spectroscopy. Authors: Muller, T. / Dieckmann, T. / Sebald, W. / Oschkinat, H. | ||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 1cyl.cif.gz | 818.3 KB | Display | PDBx/mmCIF format |
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PDB format | pdb1cyl.ent.gz | 713.6 KB | Display | PDB format |
PDBx/mmJSON format | 1cyl.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Summary document | 1cyl_validation.pdf.gz | 344.2 KB | Display | wwPDB validaton report |
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Full document | 1cyl_full_validation.pdf.gz | 634.1 KB | Display | |
Data in XML | 1cyl_validation.xml.gz | 83.8 KB | Display | |
Data in CIF | 1cyl_validation.cif.gz | 111.8 KB | Display | |
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/cy/1cyl ftp://data.pdbj.org/pub/pdb/validation_reports/cy/1cyl | HTTPS FTP |
-Related structure data
-Links
-Assembly
Deposited unit |
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1 |
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NMR ensembles |
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-Components
#1: Protein | Mass: 14989.248 Da / Num. of mol.: 1 Source method: isolated from a genetically manipulated source Source: (gene. exp.) Homo sapiens (human) / References: UniProt: P05112 |
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-Experimental details
-Experiment
Experiment | Method: SOLUTION NMR |
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-Sample preparation
Crystal grow | *PLUS Method: other / Details: NMR |
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-Processing
Software |
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NMR software | Name: X-PLOR / Developer: BRUNGER / Classification: refinement | ||||||||
NMR ensemble | Conformers submitted total number: 20 |