登録情報 | データベース: PDB / ID: 7cly |
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タイトル | Structure of the DOCK8 DHR-1 domain crystallized with di-C8-phosphatidylinositol-(4,5)-bisphosphate |
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要素 | Dedicator of cytokinesis protein 8 |
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キーワード | SIGNALING PROTEIN / Dock / guanine nucleotide exchange factor (グアニンヌクレオチド交換因子) / GTPase (GTPアーゼ) / Cdc42 / membrane (生体膜) / di-C8-PI(4 / 5)P2 / phosphoinositide (ホスファチジルイノシトール) |
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機能・相同性 | 機能・相同性情報
memory T cell proliferation / RHOJ GTPase cycle / CDC42 GTPase cycle / RAC1 GTPase cycle / dendritic cell migration / immunological synapse formation / Factors involved in megakaryocyte development and platelet production / leading edge membrane / negative regulation of T cell apoptotic process / cellular response to chemokine ...memory T cell proliferation / RHOJ GTPase cycle / CDC42 GTPase cycle / RAC1 GTPase cycle / dendritic cell migration / immunological synapse formation / Factors involved in megakaryocyte development and platelet production / leading edge membrane / negative regulation of T cell apoptotic process / cellular response to chemokine / small GTPase-mediated signal transduction / cell leading edge / lamellipodium membrane / positive regulation of T cell migration / positive regulation of establishment of T cell polarity / guanyl-nucleotide exchange factor activity / 細胞膜 / 細胞質基質 / 細胞質類似検索 - 分子機能 Dedicator of cytokinesis C, C2 domain / Dedicator of cytokinesis C/D, N-terminal / Dedicator of cytokinesis C/D, N terminal / DOCKER, Lobe A / DOCKER, Lobe B / DOCKER, Lobe C / DHR-2, Lobe C / DHR-2, Lobe B / Dedicator of cytokinesis / C2 DOCK-type domain ...Dedicator of cytokinesis C, C2 domain / Dedicator of cytokinesis C/D, N-terminal / Dedicator of cytokinesis C/D, N terminal / DOCKER, Lobe A / DOCKER, Lobe B / DOCKER, Lobe C / DHR-2, Lobe C / DHR-2, Lobe B / Dedicator of cytokinesis / C2 DOCK-type domain / DOCKER domain / Dedicator of cytokinesis, C-terminal, lobe A / Dedicator of cytokinesis, C-terminal, lobe C / DHR-2, Lobe A / C2 domain in Dock180 and Zizimin proteins / C2 DOCK-type domain profile. / DOCKER domain profile. / C2 domain superfamily / Armadillo-type fold類似検索 - ドメイン・相同性 |
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生物種 | Mus musculus (ハツカネズミ) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.432 Å |
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データ登録者 | Kukimoto-Niino, M. / Shirouzu, M. / Yokoyama, S. / Fukui, Y. / Uruno, T. |
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引用 | ジャーナル: Life Sci Alliance / 年: 2021 タイトル: A conserved PI(4,5)P2-binding domain is critical for immune regulatory function of DOCK8. 著者: Sakurai, T. / Kukimoto-Niino, M. / Kunimura, K. / Yamane, N. / Sakata, D. / Aihara, R. / Yasuda, T. / Yokoyama, S. / Shirouzu, M. / Fukui, Y. / Uruno, T. |
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履歴 | 登録 | 2020年7月22日 | 登録サイト: PDBJ / 処理サイト: PDBJ |
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改定 1.0 | 2021年2月10日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2021年3月17日 | Group: Database references / カテゴリ: citation / citation_author Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.year / _citation_author.identifier_ORCID |
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改定 1.2 | 2023年11月29日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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