登録情報 | データベース: PDB / ID: 6xa6 |
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タイトル | Crystal Structure of Human Scribble PDZ3:Vangl2 Complex |
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要素 | - Protein scribble homolog
- Vang-like protein 2
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キーワード | CYTOSOLIC PROTEIN (細胞質基質) / Cell polarity |
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機能・相同性 | 機能・相同性情報
cell migration involved in kidney development / neurotransmitter receptor transport postsynaptic membrane to endosome / extrinsic component of postsynaptic density membrane / establishment of T cell polarity / establishment of planar polarity / apoptotic process involved in morphogenesis / establishment of apical/basal cell polarity / cochlear nucleus development / synaptic vesicle targeting / Scrib-APC-beta-catenin complex ...cell migration involved in kidney development / neurotransmitter receptor transport postsynaptic membrane to endosome / extrinsic component of postsynaptic density membrane / establishment of T cell polarity / establishment of planar polarity / apoptotic process involved in morphogenesis / establishment of apical/basal cell polarity / cochlear nucleus development / synaptic vesicle targeting / Scrib-APC-beta-catenin complex / astrocyte cell migration / polarized epithelial cell differentiation / myelin sheath abaxonal region / neurotransmitter receptor transport, endosome to postsynaptic membrane / protein localization to adherens junction / cell-cell contact zone / mammary gland duct morphogenesis / post-anal tail morphogenesis / apical protein localization / non-motile cilium assembly / establishment or maintenance of epithelial cell apical/basal polarity / activation of GTPase activity / PCP/CE pathway / regulation of postsynaptic neurotransmitter receptor internalization / auditory receptor cell stereocilium organization / Wnt signaling pathway, planar cell polarity pathway / RND1 GTPase cycle / RND2 GTPase cycle / RND3 GTPase cycle / positive regulation of receptor recycling / positive chemotaxis / receptor clustering / heart looping / RHOJ GTPase cycle / RHOQ GTPase cycle / negative regulation of activated T cell proliferation / CDC42 GTPase cycle / synaptic vesicle endocytosis / negative regulation of mitotic cell cycle / 免疫シナプス / lateral plasma membrane / signaling adaptor activity / Asymmetric localization of PCP proteins / neural tube closure / 接着結合 / wound healing / 細胞接着 / 遊走 / cell-cell junction / positive regulation of type II interferon production / presynapse / 細胞結合 / lamellipodium / basolateral plasma membrane / cell population proliferation / postsynaptic density / membrane => GO:0016020 / cadherin binding / positive regulation of apoptotic process / apical plasma membrane / glutamatergic synapse / extracellular exosome / 核質 / 細胞膜類似検索 - 分子機能 Vang-like protein / Strabismus protein / Leucine-rich repeats, bacterial type / ロイシンリッチリピート / ロイシンリッチリピート / Leucine-rich repeat, typical subtype / Leucine-rich repeats, typical (most populated) subfamily / Leucine-rich repeat profile. / ロイシンリッチリピート / PDZドメイン ...Vang-like protein / Strabismus protein / Leucine-rich repeats, bacterial type / ロイシンリッチリピート / ロイシンリッチリピート / Leucine-rich repeat, typical subtype / Leucine-rich repeats, typical (most populated) subfamily / Leucine-rich repeat profile. / ロイシンリッチリピート / PDZドメイン / PDZ domain profile. / Domain present in PSD-95, Dlg, and ZO-1/2. / PDZドメイン / PDZ superfamily / Leucine-rich repeat domain superfamily類似検索 - ドメイン・相同性 Protein scribble homolog / Vang-like protein 2類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.95 Å |
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データ登録者 | How, J.Y. / Kvansakul, M. |
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資金援助 | オーストラリア, 3件 組織 | 認可番号 | 国 |
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National Health and Medical Research Council (NHMRC, Australia) | APP1103871 | オーストラリア | National Health and Medical Research Council (NHMRC, Australia) | APP1079133 | オーストラリア | Australian Research Council (ARC) | FT130101349 | オーストラリア |
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引用 | ジャーナル: Biochem.J. / 年: 2021 タイトル: Structural basis of the human Scribble-Vangl2 association in health and disease. 著者: How, J.Y. / Stephens, R.K. / Lim, K.Y.B. / Humbert, P.O. / Kvansakul, M. |
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履歴 | 登録 | 2020年6月4日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2021年3月24日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2021年4月21日 | Group: Database references / カテゴリ: citation / citation_author Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation_author.name |
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改定 1.2 | 2023年10月18日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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