登録情報 | データベース: PDB / ID: 6oel |
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タイトル | Engineered Fab bound to IL-4 receptor |
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要素 | - (engineered Fab ...) x 2
- Cytokine receptor common subunit gamma
- Interleukin-4 receptor subunit alpha
- engineered Interleukin-4, RGA variant
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キーワード | IMMUNE SYSTEM (免疫系) / cytokine receptor / fab |
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機能・相同性 | 機能・相同性情報
interleukin-4 receptor activity / interleukin-7-mediated signaling pathway / mature B cell differentiation / CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation / interleukin-15 receptor activity / interleukin-2 binding / production of molecular mediator involved in inflammatory response / interleukin-4 receptor binding / positive regulation of isotype switching to IgE isotypes / positive regulation of eosinophil chemotaxis ...interleukin-4 receptor activity / interleukin-7-mediated signaling pathway / mature B cell differentiation / CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation / interleukin-15 receptor activity / interleukin-2 binding / production of molecular mediator involved in inflammatory response / interleukin-4 receptor binding / positive regulation of isotype switching to IgE isotypes / positive regulation of eosinophil chemotaxis / B cell costimulation / negative regulation of T-helper 1 cell differentiation / negative regulation of complement-dependent cytotoxicity / T-helper 1 cell differentiation / negative regulation of macrophage activation / negative regulation of chronic inflammatory response / Interleukin-18 signaling / regulation of isotype switching / negative regulation of neuroinflammatory response / positive regulation of T-helper 2 cell differentiation / positive regulation of T cell differentiation in thymus / positive regulation of cellular respiration / negative regulation of epithelial cell migration / negative regulation of T-helper 17 cell differentiation / dendritic cell differentiation / positive regulation of T-helper 2 cell cytokine production / Interleukin-9 signaling / Interleukin-21 signaling / interleukin-9-mediated signaling pathway / positive regulation of isotype switching to IgG isotypes / positive regulation of amyloid-beta clearance / neuroinflammatory response / interleukin-4-mediated signaling pathway / positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation / interleukin-2-mediated signaling pathway / マクロファージ / myeloid dendritic cell differentiation / positive regulation of mast cell degranulation / positive regulation of mononuclear cell migration / regulation of phosphorylation / type 2 immune response / STAT3 nuclear events downstream of ALK signaling / positive regulation of macrophage activation / activation of Janus kinase activity / interleukin-15-mediated signaling pathway / positive regulation of MHC class II biosynthetic process / T-helper 2 cell differentiation / Interleukin-15 signaling / cytokine receptor activity / Interleukin-2 signaling / negative regulation of cellular response to transforming growth factor beta stimulus / positive regulation of T cell differentiation / positive regulation of B cell differentiation / positive regulation of interleukin-13 production / positive regulation of myoblast fusion / cytokine binding / positive regulation of ATP biosynthetic process / defense response to protozoan / negative regulation of osteoclast differentiation / positive regulation of macroautophagy / positive regulation of interleukin-10 production / immunoglobulin mediated immune response / positive regulation of immunoglobulin production / negative regulation of acute inflammatory response / centriolar satellite / negative regulation of tumor necrosis factor production / regulation of immune response / Interleukin receptor SHC signaling / coreceptor activity / positive regulation of phagocytosis / negative regulation of endothelial cell apoptotic process / positive regulation of B cell proliferation / positive regulation of chemokine production / positive regulation of tyrosine phosphorylation of STAT protein / positive regulation of defense response to virus by host / extrinsic apoptotic signaling pathway in absence of ligand / cholesterol metabolic process / positive regulation of T cell proliferation / Interleukin-7 signaling / T細胞 / B cell differentiation / innate immune response in mucosa / cytokine activity / negative regulation of extrinsic apoptotic signaling pathway / microglial cell activation / growth factor activity / negative regulation of inflammatory response / positive regulation of receptor-mediated endocytosis / cytokine-mediated signaling pathway / T cell differentiation in thymus / 遺伝子発現 / positive regulation of cold-induced thermogenesis / RAF/MAP kinase cascade / Interleukin-4 and Interleukin-13 signaling / receptor complex / エンドソーム / positive regulation of cell migration / 免疫応答 / external side of plasma membrane / negative regulation of DNA-templated transcription類似検索 - 分子機能 Interleukin-4 receptor alpha, N-terminal / Interleukin-4 receptor alpha chain, N-terminal / : / : / Cytokine receptor-like factor 2-like, D1 domain / Cytokine receptor-like factor 2-like, D2 domain / インターロイキン-4 / インターロイキン-4 / Interleukin-4/interleukin-13 / Interleukin-4/interleukin-13, conserved site ...Interleukin-4 receptor alpha, N-terminal / Interleukin-4 receptor alpha chain, N-terminal / : / : / Cytokine receptor-like factor 2-like, D1 domain / Cytokine receptor-like factor 2-like, D2 domain / インターロイキン-4 / インターロイキン-4 / Interleukin-4/interleukin-13 / Interleukin-4/interleukin-13, conserved site / Interleukins -4 and -13 signature. / Interleukins 4 and 13 / Short hematopoietin receptor family 1 signature. / Short hematopoietin receptor, family 1, conserved site / Growth Hormone; Chain: A; - #10 / Four-helical cytokine-like, core / Growth Hormone; Chain: A; / Fibronectin type-III domain profile. / Fibronectin type III / Fibronectin type III superfamily / 抗体 / Immunoglobulin-like fold / Up-down Bundle / Immunoglobulin-like / サンドイッチ / Mainly Beta / Mainly Alpha類似検索 - ドメイン・相同性 硝酸塩 / インターロイキン-4 / Interleukin-4 receptor subunit alpha / Cytokine receptor common subunit gamma類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 3.1 Å |
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データ登録者 | Jude, K.M. / Moraga, I. / Spangler, J.B. / Garcia, K.C. |
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資金援助 | 米国, 1件 組織 | 認可番号 | 国 |
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National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID) | R01 AI51321 | 米国 |
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引用 | ジャーナル: J.Biol.Chem. / 年: 2019 タイトル: A strategy for the selection of monovalent antibodies that span protein dimer interfaces. 著者: Spangler, J.B. / Moraga, I. / Jude, K.M. / Savvides, C.S. / Garcia, K.C. |
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履歴 | 登録 | 2019年3月27日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2019年8月7日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2019年8月21日 | Group: Data collection / Database references / カテゴリ: citation / citation_author Item: _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed ..._citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation_author.identifier_ORCID |
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改定 1.2 | 2019年10月2日 | Group: Data collection / Database references / カテゴリ: chem_comp / citation / citation_author Item: _chem_comp.type / _citation.journal_volume ..._chem_comp.type / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation_author.identifier_ORCID |
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改定 1.3 | 2019年12月18日 | Group: Author supporting evidence / カテゴリ: pdbx_audit_support / Item: _pdbx_audit_support.funding_organization |
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改定 2.0 | 2020年7月29日 | Group: Atomic model / Data collection ...Atomic model / Data collection / Derived calculations / Structure summary カテゴリ: atom_site / chem_comp ...atom_site / chem_comp / entity / pdbx_branch_scheme / pdbx_chem_comp_identifier / pdbx_entity_branch / pdbx_entity_branch_descriptor / pdbx_entity_branch_link / pdbx_entity_branch_list / pdbx_entity_nonpoly / pdbx_nonpoly_scheme / pdbx_struct_assembly_gen / struct_asym / struct_conn / struct_site / struct_site_gen Item: _atom_site.B_iso_or_equiv / _atom_site.Cartn_x ..._atom_site.B_iso_or_equiv / _atom_site.Cartn_x / _atom_site.Cartn_y / _atom_site.Cartn_z / _atom_site.auth_asym_id / _atom_site.auth_atom_id / _atom_site.auth_comp_id / _atom_site.auth_seq_id / _atom_site.label_asym_id / _atom_site.label_atom_id / _atom_site.label_comp_id / _atom_site.label_entity_id / _atom_site.type_symbol / _chem_comp.name / _chem_comp.type / _entity.formula_weight / _entity.pdbx_description / _entity.pdbx_number_of_molecules / _entity.type / _pdbx_struct_assembly_gen.asym_id_list / _struct_conn.pdbx_role / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id 解説: Carbohydrate remediation / Provider: repository / タイプ: Remediation |
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改定 2.1 | 2023年10月11日 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Refinement description / Structure summary カテゴリ: chem_comp / chem_comp_atom ...chem_comp / chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_conn Item: _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI ..._chem_comp.pdbx_synonyms / _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_conn.pdbx_leaving_atom_flag |
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