Entry Database : PDB / ID : 3bpl Structure visualization Downloads & linksTitle Crystal structure of the IL4-IL4R-Common Gamma ternary complex ComponentsCytokine receptor common gamma chain Interleukin-4 Interleukin-4 receptor alpha chain DetailsKeywords Cytokine/Cytokine receptor / IL4 / IL13 / receptor / cytokine / B-cell activation / Glycoprotein / Growth factor / Secreted / Immune response / Membrane / Phosphoprotein / Transmembrane / Disease mutation / Host-virus interaction / SCID / Cytokine-receptor COMPLEX / Cytokine-Cytokine receptor COMPLEXFunction / homology Function and homology informationFunction Domain/homology Component
interleukin-4 receptor activity / mature B cell differentiation / interleukin-15 receptor activity / interleukin-7-mediated signaling pathway / interleukin-2 binding / CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation / production of molecular mediator involved in inflammatory response / interleukin-4 receptor binding / positive regulation of isotype switching to IgE isotypes / negative regulation of T-helper 1 cell differentiation ... interleukin-4 receptor activity / mature B cell differentiation / interleukin-15 receptor activity / interleukin-7-mediated signaling pathway / interleukin-2 binding / CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation / production of molecular mediator involved in inflammatory response / interleukin-4 receptor binding / positive regulation of isotype switching to IgE isotypes / negative regulation of T-helper 1 cell differentiation / negative regulation of complement-dependent cytotoxicity / T-helper 1 cell differentiation / positive regulation of cellular respiration / regulation of isotype switching / Interleukin-18 signaling / negative regulation of neuroinflammatory response / positive regulation of T cell differentiation in thymus / positive regulation of T-helper 2 cell differentiation / negative regulation of epithelial cell migration / positive regulation of T-helper 2 cell cytokine production / Interleukin-9 signaling / Interleukin-21 signaling / interleukin-9-mediated signaling pathway / dendritic cell differentiation / positive regulation of isotype switching to IgG isotypes / neuroinflammatory response / interleukin-4-mediated signaling pathway / positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation / positive regulation of mast cell degranulation / interleukin-2-mediated signaling pathway / macrophage activation / positive regulation of interleukin-13 production / myeloid dendritic cell differentiation / cellular homeostasis / positive regulation of amyloid-beta clearance / regulation of phosphorylation / type 2 immune response / activation of Janus kinase activity / T-helper 2 cell differentiation / interleukin-15-mediated signaling pathway / STAT3 nuclear events downstream of ALK signaling / positive regulation of MHC class II biosynthetic process / positive regulation of macrophage activation / Interleukin-15 signaling / Interleukin-2 signaling / cytokine receptor activity / negative regulation of cellular response to transforming growth factor beta stimulus / positive regulation of T cell differentiation / positive regulation of immunoglobulin production / positive regulation of B cell differentiation / positive regulation of myoblast fusion / positive regulation of ATP biosynthetic process / defense response to protozoan / negative regulation of osteoclast differentiation / cytokine binding / positive regulation of interleukin-10 production / positive regulation of macroautophagy / negative regulation of tumor necrosis factor production / centriolar satellite / regulation of immune response / immunoglobulin mediated immune response / Interleukin receptor SHC signaling / coreceptor activity / negative regulation of endothelial cell apoptotic process / positive regulation of chemokine production / positive regulation of T cell proliferation / positive regulation of B cell proliferation / positive regulation of phagocytosis / positive regulation of tyrosine phosphorylation of STAT protein / T cell activation / Interleukin-7 signaling / cholesterol metabolic process / B cell differentiation / cytokine activity / growth factor activity / cytokine-mediated signaling pathway / negative regulation of inflammatory response / positive regulation of receptor-mediated endocytosis / positive regulation of cold-induced thermogenesis / gene expression / T cell differentiation in thymus / RAF/MAP kinase cascade / Interleukin-4 and Interleukin-13 signaling / receptor complex / endosome / positive regulation of cell migration / immune response / external side of plasma membrane / negative regulation of DNA-templated transcription / positive regulation of cell population proliferation / positive regulation of gene expression / negative regulation of apoptotic process / positive regulation of DNA-templated transcription / negative regulation of transcription by RNA polymerase II / cell surface / signal transduction / endoplasmic reticulum / positive regulation of transcription by RNA polymerase II / extracellular space / extracellular region Similarity search - Function Interleukin-4 receptor alpha, N-terminal / Interleukin-4 receptor alpha chain, N-terminal / : / : / Cytokine receptor-like factor 2-like, D1 domain / Cytokine receptor-like factor 2-like, D2 domain / Interleukin-4 / Interleukin 4 / Interleukin-4/interleukin-13 / Interleukin-4/interleukin-13, conserved site ... Interleukin-4 receptor alpha, N-terminal / Interleukin-4 receptor alpha chain, N-terminal / : / : / Cytokine receptor-like factor 2-like, D1 domain / Cytokine receptor-like factor 2-like, D2 domain / Interleukin-4 / Interleukin 4 / Interleukin-4/interleukin-13 / Interleukin-4/interleukin-13, conserved site / Interleukins -4 and -13 signature. / Interleukins 4 and 13 / Short hematopoietin receptor family 1 signature. / Interleukin-6 receptor alpha chain, binding / Short hematopoietin receptor, family 1, conserved site / Growth Hormone; Chain: A; - #10 / Four-helical cytokine-like, core / Growth Hormone; Chain: A; / Fibronectin type-III domain profile. / Fibronectin type III / Fibronectin type III superfamily / Immunoglobulins / Immunoglobulin-like fold / Up-down Bundle / Immunoglobulin-like / Sandwich / Mainly Beta / Mainly Alpha Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.93 Å DetailsAuthors Garcia, K.C. CitationJournal : Cell(Cambridge,Mass.) / Year : 2008Title : Molecular and Structural Basis of Cytokine Receptor Pleiotropy in the Interleukin-4/13 System.Authors : Laporte, S.L. / Juo, Z.S. / Vaclavikova, J. / Colf, L.A. / Qi, X. / Heller, N.M. / Keegan, A.D. / Garcia, K.C. History Deposition Dec 18, 2007 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Feb 5, 2008 Provider : repository / Type : Initial releaseRevision 1.1 Jul 13, 2011 Group : Advisory / Version format complianceRevision 2.0 Jul 29, 2020 Group : Advisory / Atomic model ... Advisory / Atomic model / Data collection / Database references / Derived calculations / Structure summary Category : atom_site / chem_comp ... atom_site / chem_comp / entity / pdbx_branch_scheme / pdbx_chem_comp_identifier / pdbx_entity_branch / pdbx_entity_branch_descriptor / pdbx_entity_branch_link / pdbx_entity_branch_list / pdbx_entity_nonpoly / pdbx_nonpoly_scheme / pdbx_struct_assembly_gen / pdbx_unobs_or_zero_occ_atoms / struct_asym / struct_conn / struct_ref_seq_dif / struct_site / struct_site_gen Item : _atom_site.auth_asym_id / _atom_site.auth_seq_id ... _atom_site.auth_asym_id / _atom_site.auth_seq_id / _atom_site.label_asym_id / _atom_site.label_entity_id / _chem_comp.name / _chem_comp.type / _pdbx_struct_assembly_gen.asym_id_list / _struct_conn.pdbx_leaving_atom_flag / _struct_conn.pdbx_role / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_ref_seq_dif.details Description : Carbohydrate remediation / Provider : repository / Type : RemediationRevision 2.1 Oct 20, 2021 Group : Advisory / Database references / Structure summaryCategory : chem_comp / database_2 ... chem_comp / database_2 / pdbx_unobs_or_zero_occ_atoms / struct_ref_seq_dif Item : _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI ... _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details
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