登録情報 | データベース: PDB / ID: 6hkc |
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タイトル | Solution structure of the Sushi 1 domain of GABAbR1a |
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要素 | Gamma-aminobutyric acid type B receptor subunit 1 |
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キーワード | MEMBRANE PROTEIN (膜タンパク質) / neurotransmitter receptor (神経伝達物質受容体) / G protein coupled receptors |
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機能・相同性 | 機能・相同性情報
G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential / GABA B receptor activation / G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential / G protein-coupled GABA receptor complex / negative regulation of gamma-aminobutyric acid secretion / neuron-glial cell signaling / G protein-coupled GABA receptor activity / G protein-coupled receptor heterodimeric complex / negative regulation of epinephrine secretion / negative regulation of dopamine secretion ...G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential / GABA B receptor activation / G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential / G protein-coupled GABA receptor complex / negative regulation of gamma-aminobutyric acid secretion / neuron-glial cell signaling / G protein-coupled GABA receptor activity / G protein-coupled receptor heterodimeric complex / negative regulation of epinephrine secretion / negative regulation of dopamine secretion / positive regulation of growth hormone secretion / extracellular matrix protein binding / Class C/3 (Metabotropic glutamate/pheromone receptors) / synaptic transmission, GABAergic / gamma-aminobutyric acid signaling pathway / positive regulation of glutamate secretion / negative regulation of synaptic transmission / axolemma / GABA-ergic synapse / adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway / dendritic shaft / response to nicotine / ミトコンドリア / Schaffer collateral - CA1 synapse / Activation of G protein gated Potassium channels / Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits / osteoblast differentiation / シナプス小胞 / presynaptic membrane / G alpha (i) signalling events / postsynaptic membrane / response to ethanol / 樹状突起スパイン / protein heterodimerization activity / negative regulation of cell population proliferation / neuronal cell body / glutamatergic synapse / endoplasmic reticulum membrane / extracellular space / 細胞膜類似検索 - 分子機能 GPCR family 3, gamma-aminobutyric acid receptor, type B1 / GPCR family 3, GABA-B receptor / GPCR family 3, C-terminal / 7 transmembrane sweet-taste receptor of 3 GCPR / G-protein coupled receptors family 3 profile. / Sushi repeat (SCR repeat) / Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR) / Sushi/SCR/CCP domain / Sushi/CCP/SCR domain profile. / Sushi/SCR/CCP superfamily ...GPCR family 3, gamma-aminobutyric acid receptor, type B1 / GPCR family 3, GABA-B receptor / GPCR family 3, C-terminal / 7 transmembrane sweet-taste receptor of 3 GCPR / G-protein coupled receptors family 3 profile. / Sushi repeat (SCR repeat) / Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR) / Sushi/SCR/CCP domain / Sushi/CCP/SCR domain profile. / Sushi/SCR/CCP superfamily / Receptor, ligand binding region / Receptor family ligand binding region / Periplasmic binding protein-like I類似検索 - ドメイン・相同性 Gamma-aminobutyric acid type B receptor subunit 1類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | 溶液NMR / simulated annealing |
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データ登録者 | Volkov, A.N. / Buts, L. / Van Molle, I. |
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資金援助 | ベルギー, 2件 組織 | 認可番号 | 国 |
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Research Foundation - Flanders | Odyssey | ベルギー | European Research Council | 311083 | ベルギー |
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引用 | ジャーナル: Science / 年: 2019 タイトル: Secreted amyloid-beta precursor protein functions as a GABABR1a ligand to modulate synaptic transmission. 著者: Rice, H.C. / de Malmazet, D. / Schreurs, A. / Frere, S. / Van Molle, I. / Volkov, A.N. / Creemers, E. / Vertkin, I. / Nys, J. / Ranaivoson, F.M. / Comoletti, D. / Savas, J.N. / Remaut, H. / ...著者: Rice, H.C. / de Malmazet, D. / Schreurs, A. / Frere, S. / Van Molle, I. / Volkov, A.N. / Creemers, E. / Vertkin, I. / Nys, J. / Ranaivoson, F.M. / Comoletti, D. / Savas, J.N. / Remaut, H. / Balschun, D. / Wierda, K.D. / Slutsky, I. / Farrow, K. / De Strooper, B. / de Wit, J. |
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履歴 | 登録 | 2018年9月6日 | 登録サイト: PDBE / 処理サイト: PDBE |
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改定 1.0 | 2019年1月23日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2019年5月8日 | Group: Data collection / カテゴリ: pdbx_nmr_software / Item: _pdbx_nmr_software.name |
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改定 1.2 | 2023年6月14日 | Group: Data collection / Database references / Other カテゴリ: database_2 / pdbx_database_status / pdbx_nmr_spectrometer Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_nmr_data / _pdbx_nmr_spectrometer.model |
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