登録情報 | データベース: PDB / ID: 5ue3 |
---|
タイトル | proMMP-9desFnII |
---|
要素 | Matrix metalloproteinase-9マトリックスメタロプロテアーゼ |
---|
キーワード | HYDROLASE (加水分解酵素) / prommp9 / zymogen (酵素前駆体) |
---|
機能・相同性 | 機能・相同性情報
ゼラチナーゼB / negative regulation of epithelial cell differentiation involved in kidney development / negative regulation of cation channel activity / negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway / cellular response to UV-A / positive regulation of keratinocyte migration / regulation of neuroinflammatory response / positive regulation of epidermal growth factor receptor signaling pathway / Assembly of collagen fibrils and other multimeric structures / Activation of Matrix Metalloproteinases ...ゼラチナーゼB / negative regulation of epithelial cell differentiation involved in kidney development / negative regulation of cation channel activity / negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway / cellular response to UV-A / positive regulation of keratinocyte migration / regulation of neuroinflammatory response / positive regulation of epidermal growth factor receptor signaling pathway / Assembly of collagen fibrils and other multimeric structures / Activation of Matrix Metalloproteinases / endodermal cell differentiation / positive regulation of release of cytochrome c from mitochondria / response to amyloid-beta / macrophage differentiation / Collagen degradation / EPH-ephrin mediated repulsion of cells / collagen catabolic process / extracellular matrix disassembly / ephrin receptor signaling pathway / positive regulation of DNA binding / negative regulation of intrinsic apoptotic signaling pathway / 着床 / positive regulation of vascular associated smooth muscle cell proliferation / cellular response to cadmium ion / collagen binding / Degradation of the extracellular matrix / extracellular matrix organization / positive regulation of receptor binding / skeletal system development / Signaling by SCF-KIT / metalloendopeptidase activity / cellular response to reactive oxygen species / metallopeptidase activity / 遊走 / tertiary granule lumen / peptidase activity / collagen-containing extracellular matrix / Interleukin-4 and Interleukin-13 signaling / endopeptidase activity / cellular response to lipopolysaccharide / ficolin-1-rich granule lumen / Extra-nuclear estrogen signaling / positive regulation of protein phosphorylation / positive regulation of apoptotic process / serine-type endopeptidase activity / apoptotic process / Neutrophil degranulation / negative regulation of apoptotic process / タンパク質分解 / extracellular space / extracellular exosome / zinc ion binding / extracellular region / identical protein binding類似検索 - 分子機能 フィブロネクチンII型ドメイン / Fibronectin type II domain superfamily / フィブロネクチンII型ドメイン / Fibronectin type-II collagen-binding domain signature. / Fibronectin type-II collagen-binding domain profile. / Fibronectin type 2 domain / Hemopexin, conserved site / Hemopexin domain signature. / Hemopexin-like domain / Peptidase M10A, cysteine switch, zinc binding site ...フィブロネクチンII型ドメイン / Fibronectin type II domain superfamily / フィブロネクチンII型ドメイン / Fibronectin type-II collagen-binding domain signature. / Fibronectin type-II collagen-binding domain profile. / Fibronectin type 2 domain / Hemopexin, conserved site / Hemopexin domain signature. / Hemopexin-like domain / Peptidase M10A, cysteine switch, zinc binding site / Matrixins cysteine switch. / Putative peptidoglycan binding domain / Hemopexin-like repeats / Hemopexin-like domain superfamily / ヘモペキシン / Hemopexin repeat profile. / Hemopexin-like repeats. / Peptidase M10A / Peptidase M10A, catalytic domain / Peptidase M10, metallopeptidase / マトリックスメタロプロテアーゼ / PGBD-like superfamily / Peptidase, metallopeptidase / Zinc-dependent metalloprotease / Collagenase (Catalytic Domain) / Collagenase (Catalytic Domain) / Metallopeptidase, catalytic domain superfamily / Kringle-like fold / Neutral zinc metallopeptidases, zinc-binding region signature. / 3-Layer(aba) Sandwich / Alpha Beta類似検索 - ドメイン・相同性 |
---|
生物種 | Homo sapiens (ヒト) |
---|
手法 | X線回折 / シンクロトロン / 解像度: 1.599 Å |
---|
データ登録者 | Alexander, R.S. / Spurlino, J. / Milligan, C. |
---|
引用 | ジャーナル: J. Biol. Chem. / 年: 2017 タイトル: Discovery of a highly selective chemical inhibitor of matrix metalloproteinase-9 (MMP-9) that allosterically inhibits zymogen activation. 著者: Scannevin, R.H. / Alexander, R. / Haarlander, T.M. / Burke, S.L. / Singer, M. / Huo, C. / Zhang, Y.M. / Maguire, D. / Spurlino, J. / Deckman, I. / Carroll, K.I. / Lewandowski, F. / Devine, E. ...著者: Scannevin, R.H. / Alexander, R. / Haarlander, T.M. / Burke, S.L. / Singer, M. / Huo, C. / Zhang, Y.M. / Maguire, D. / Spurlino, J. / Deckman, I. / Carroll, K.I. / Lewandowski, F. / Devine, E. / Dzordzorme, K. / Tounge, B. / Milligan, C. / Bayoumy, S. / Williams, R. / Schalk-Hihi, C. / Leonard, K. / Jackson, P. / Todd, M. / Kuo, L.C. / Rhodes, K.J. |
---|
履歴 | 登録 | 2016年12月29日 | 登録サイト: RCSB / 処理サイト: RCSB |
---|
改定 1.0 | 2017年9月13日 | Provider: repository / タイプ: Initial release |
---|
改定 1.1 | 2017年11月8日 | Group: Database references / カテゴリ: citation / citation_author Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation_author.name |
---|
改定 1.2 | 2024年3月6日 | Group: Advisory / Data collection ...Advisory / Data collection / Database references / Derived calculations カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_unobs_or_zero_occ_atoms / struct_conn Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_conn.pdbx_dist_value / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id |
---|
|
---|