登録情報 | データベース: PDB / ID: 5k2b |
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タイトル | 2.5 angstrom A2a adenosine receptor structure with MR phasing using XFEL data |
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要素 | Adenosine receptor A2a/Soluble cytochrome b562 chimera |
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キーワード | MEMBRANE PROTEIN (膜タンパク質) / A2a adenosine receptor / GPCR (Gタンパク質共役受容体) / Structural Genomics (構造ゲノミクス) / PSI-Biology / GPCR Network |
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機能・相同性 | 機能・相同性情報
positive regulation of acetylcholine secretion, neurotransmission / positive regulation of circadian sleep/wake cycle, sleep / regulation of norepinephrine secretion / negative regulation of alpha-beta T cell activation / Adenosine P1 receptors / G protein-coupled adenosine receptor activity / G protein-coupled adenosine receptor signaling pathway / response to purine-containing compound / 知覚 / positive regulation of urine volume ...positive regulation of acetylcholine secretion, neurotransmission / positive regulation of circadian sleep/wake cycle, sleep / regulation of norepinephrine secretion / negative regulation of alpha-beta T cell activation / Adenosine P1 receptors / G protein-coupled adenosine receptor activity / G protein-coupled adenosine receptor signaling pathway / response to purine-containing compound / 知覚 / positive regulation of urine volume / NGF-independant TRKA activation / Surfactant metabolism / protein kinase C-activating G protein-coupled receptor signaling pathway / synaptic transmission, dopaminergic / inhibitory postsynaptic potential / negative regulation of vascular permeability / type 5 metabotropic glutamate receptor binding / positive regulation of glutamate secretion / 循環器 / synaptic transmission, cholinergic / response to caffeine / 中間径フィラメント / eating behavior / presynaptic active zone / alpha-actinin binding / 脱分極 / regulation of calcium ion transport / asymmetric synapse / axolemma / response to inorganic substance / cellular defense response / prepulse inhibition / 食作用 / positive regulation of apoptotic signaling pathway / response to amphetamine / excitatory postsynaptic potential / presynaptic modulation of chemical synaptic transmission / positive regulation of synaptic transmission, glutamatergic / neuron projection morphogenesis / regulation of mitochondrial membrane potential / locomotory behavior / synaptic transmission, glutamatergic / central nervous system development / positive regulation of long-term synaptic potentiation / astrocyte activation / apoptotic signaling pathway / positive regulation of synaptic transmission, GABAergic / positive regulation of protein secretion / adenylate cyclase-modulating G protein-coupled receptor signaling pathway / adenylate cyclase-activating G protein-coupled receptor signaling pathway / negative regulation of inflammatory response / vasodilation / 凝固・線溶系 / cell-cell signaling / presynaptic membrane / G alpha (s) signalling events / postsynaptic membrane / negative regulation of neuron apoptotic process / electron transfer activity / ペリプラズム / calmodulin binding / response to xenobiotic stimulus / 炎症 / iron ion binding / negative regulation of cell population proliferation / neuronal cell body / 樹状突起 / glutamatergic synapse / apoptotic process / lipid binding / heme binding / protein-containing complex binding / regulation of DNA-templated transcription / enzyme binding / 生体膜 / identical protein binding / 細胞膜類似検索 - 分子機能 Adenosine A2A receptor / アデノシン受容体 / Cytochrome b562 / Cytochrome b562 / Cytochrome c/b562 / Serpentine type 7TM GPCR chemoreceptor Srsx / G-protein coupled receptors family 1 signature. / G protein-coupled receptor, rhodopsin-like / GPCR, rhodopsin-like, 7TM / G-protein coupled receptors family 1 profile. / 7 transmembrane receptor (rhodopsin family)類似検索 - ドメイン・相同性 コレステロール / オレイン酸 / (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate / (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate / Chem-ZMA / Soluble cytochrome b562 / Adenosine receptor A2a類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) Escherichia coli (大腸菌) |
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手法 | X線回折 / 自由電子レーザー / 分子置換 / 解像度: 2.5 Å |
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データ登録者 | Batyuk, A. / Galli, L. / Ishchenko, A. / Han, G.W. / Gati, C. / Popov, P. / Lee, M.-Y. / Stauch, B. / White, T.A. / Barty, A. ...Batyuk, A. / Galli, L. / Ishchenko, A. / Han, G.W. / Gati, C. / Popov, P. / Lee, M.-Y. / Stauch, B. / White, T.A. / Barty, A. / Aquila, A. / Hunter, M.S. / Liang, M. / Boutet, S. / Pu, M. / Liu, Z.-J. / Nelson, G. / James, D. / Li, C. / Zhao, Y. / Spence, J.C.H. / Liu, W. / Fromme, P. / Katritch, V. / Weierstall, U. / Stevens, R.C. / Cherezov, V. / GPCR Network (GPCR) |
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引用 | ジャーナル: Sci Adv / 年: 2016 タイトル: Native phasing of x-ray free-electron laser data for a G protein-coupled receptor. 著者: Batyuk, A. / Galli, L. / Ishchenko, A. / Han, G.W. / Gati, C. / Popov, P.A. / Lee, M.Y. / Stauch, B. / White, T.A. / Barty, A. / Aquila, A. / Hunter, M.S. / Liang, M. / Boutet, S. / Pu, M. / ...著者: Batyuk, A. / Galli, L. / Ishchenko, A. / Han, G.W. / Gati, C. / Popov, P.A. / Lee, M.Y. / Stauch, B. / White, T.A. / Barty, A. / Aquila, A. / Hunter, M.S. / Liang, M. / Boutet, S. / Pu, M. / Liu, Z.J. / Nelson, G. / James, D. / Li, C. / Zhao, Y. / Spence, J.C. / Liu, W. / Fromme, P. / Katritch, V. / Weierstall, U. / Stevens, R.C. / Cherezov, V. |
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履歴 | 登録 | 2016年5月18日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2016年9月21日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2016年10月12日 | Group: Database references |
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改定 1.2 | 2018年2月14日 | Group: Data collection / Derived calculations / カテゴリ: diffrn_source / pdbx_struct_oper_list Item: _diffrn_source.pdbx_synchrotron_beamline / _diffrn_source.pdbx_synchrotron_site / _pdbx_struct_oper_list.symmetry_operation |
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改定 1.3 | 2018年11月28日 | Group: Data collection カテゴリ: diffrn / pdbx_serial_crystallography_data_reduction ...diffrn / pdbx_serial_crystallography_data_reduction / pdbx_serial_crystallography_measurement / pdbx_serial_crystallography_sample_delivery / pdbx_serial_crystallography_sample_delivery_injection Item: _diffrn.pdbx_serial_crystal_experiment |
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改定 1.4 | 2023年9月27日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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