登録情報 | データベース: PDB / ID: 5hvj |
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タイトル | Crystal structure of LIMK1 D460N mutant in complex with AMP-PNP |
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要素 | LIM domain kinase 1 |
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キーワード | TRANSFERASE (転移酵素) / kinase ATP analog actin-remodeling |
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機能・相同性 | 機能・相同性情報
positive regulation of actin filament bundle assembly / negative regulation of ubiquitin-protein transferase activity / RHO GTPases Activate ROCKs / axon extension / Sema4D induced cell migration and growth-cone collapse / Fc-gamma receptor signaling pathway involved in phagocytosis / stress fiber assembly / RHO GTPases activate PAKs / Rho protein signal transduction / Sema3A PAK dependent Axon repulsion ...positive regulation of actin filament bundle assembly / negative regulation of ubiquitin-protein transferase activity / RHO GTPases Activate ROCKs / axon extension / Sema4D induced cell migration and growth-cone collapse / Fc-gamma receptor signaling pathway involved in phagocytosis / stress fiber assembly / RHO GTPases activate PAKs / Rho protein signal transduction / Sema3A PAK dependent Axon repulsion / positive regulation of axon extension / positive regulation of stress fiber assembly / EPHB-mediated forward signaling / heat shock protein binding / male germ cell nucleus / Regulation of actin dynamics for phagocytic cup formation / lamellipodium / nervous system development / actin cytoskeleton organization / 細胞骨格 / non-specific serine/threonine protein kinase / protein kinase activity / neuron projection / nuclear speck / protein phosphorylation / focal adhesion / protein serine kinase activity / protein serine/threonine kinase activity / シグナル伝達 / ATP binding / 生体膜 / metal ion binding / 細胞核 / 細胞質基質 / 細胞質類似検索 - 分子機能 LIM zinc-binding domain signature. / LIM domain / Zinc-binding domain present in Lin-11, Isl-1, Mec-3. / Zinc finger, LIM-type / LIM domain profile. / PDZドメイン / PDZ domain profile. / Domain present in PSD-95, Dlg, and ZO-1/2. / PDZドメイン / PDZ superfamily ...LIM zinc-binding domain signature. / LIM domain / Zinc-binding domain present in Lin-11, Isl-1, Mec-3. / Zinc finger, LIM-type / LIM domain profile. / PDZドメイン / PDZ domain profile. / Domain present in PSD-95, Dlg, and ZO-1/2. / PDZドメイン / PDZ superfamily / Protein tyrosine and serine/threonine kinase / Serine-threonine/tyrosine-protein kinase, catalytic domain / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha Beta類似検索 - ドメイン・相同性 PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER / LIM domain kinase 1類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.2 Å |
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データ登録者 | Hamill, S. / Boggon, T.J. |
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資金援助 | 米国, 2件 組織 | 認可番号 | 国 |
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National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) | R01GM102262 | 米国 | National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) | P41GM103403 | 米国 |
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引用 | ジャーナル: Mol.Cell / 年: 2016 タイトル: Structural Basis for Noncanonical Substrate Recognition of Cofilin/ADF Proteins by LIM Kinases. 著者: Hamill, S. / Lou, H.J. / Turk, B.E. / Boggon, T.J. |
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履歴 | 登録 | 2016年1月28日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2016年5月4日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2016年5月18日 | Group: Database references |
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改定 1.2 | 2017年9月13日 | Group: Author supporting evidence / Database references / Derived calculations カテゴリ: citation / pdbx_audit_support / pdbx_struct_oper_list Item: _citation.journal_id_CSD / _pdbx_audit_support.funding_organization / _pdbx_struct_oper_list.symmetry_operation |
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改定 1.3 | 2019年12月25日 | Group: Author supporting evidence / カテゴリ: pdbx_audit_support / Item: _pdbx_audit_support.funding_organization |
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改定 1.4 | 2023年9月27日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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