登録情報 データベース : PDB / ID : 5f85 構造の表示 ダウンロードとリンクタイトル Crystal structure of Drosophila Poglut1 (Rumi) complexed with its substrate protein (EGF repeat) and UDP 要素Coagulation factor IX 第IX因子 O-glucosyltransferase rumi 詳細キーワード TRANSFERASE/HYDROLASE / glycosyltransferase (グリコシルトランスフェラーゼ) / protein O-glucosyltransferase / Notch regulation / EGF repeat / TRANSFERASE-HYDROLASE complex機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
EGF-domain serine glucosyltransferase activity / EGF-domain serine xylosyltransferase activity / muscle tissue development / rhabdomere development / protein O-linked glycosylation via serine / UDP-xylosyltransferase activity / Defective F9 secretion / Defective gamma-carboxylation of F9 / 第IX因子 / UDP-glucosyltransferase activity ... EGF-domain serine glucosyltransferase activity / EGF-domain serine xylosyltransferase activity / muscle tissue development / rhabdomere development / protein O-linked glycosylation via serine / UDP-xylosyltransferase activity / Defective F9 secretion / Defective gamma-carboxylation of F9 / 第IX因子 / UDP-glucosyltransferase activity / glucosyltransferase activity / Defective F9 activation / protein O-linked glycosylation / Defective factor IX causes thrombophilia / Defective cofactor function of FVIIIa variant / Defective F9 variant does not activate FX / zymogen activation / Extrinsic Pathway of Fibrin Clot Formation / 転移酵素; グリコシル基を移すもの; 六炭糖残基を移すもの / positive regulation of Notch signaling pathway / negative regulation of Notch signaling pathway / ヒドロキシル化 / 細胞内膜系 / 細胞分化 / Gamma-carboxylation of protein precursors / Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus / Removal of aminoterminal propeptides from gamma-carboxylated proteins / Notchシグナリング / Intrinsic Pathway of Fibrin Clot Formation / Golgi lumen / 凝固・線溶系 / collagen-containing extracellular matrix / endopeptidase activity / 小胞体 / serine-type endopeptidase activity / calcium ion binding / タンパク質分解 / extracellular space / extracellular exosome / extracellular region / metal ion binding / 細胞膜 類似検索 - 分子機能 Glycosyl transferase CAP10 domain / Glycosyl transferase family 90 / Putative lipopolysaccharide-modifying enzyme. / Endoplasmic reticulum targeting sequence. / Peptidase S1A, coagulation factor VII/IX/X/C/Z / Coagulation factor-like, Gla domain superfamily / Coagulation Factor Xa inhibitory site / EGF-type aspartate/asparagine hydroxylation site / EGF様ドメイン / EGF-like calcium-binding, conserved site ... Glycosyl transferase CAP10 domain / Glycosyl transferase family 90 / Putative lipopolysaccharide-modifying enzyme. / Endoplasmic reticulum targeting sequence. / Peptidase S1A, coagulation factor VII/IX/X/C/Z / Coagulation factor-like, Gla domain superfamily / Coagulation Factor Xa inhibitory site / EGF-type aspartate/asparagine hydroxylation site / EGF様ドメイン / EGF-like calcium-binding, conserved site / Calcium-binding EGF-like domain signature. / Aspartic acid and asparagine hydroxylation site. / EGF-like calcium-binding domain / Calcium-binding EGF-like domain / Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain / Gamma-carboxyglutamic acid-rich (GLA) domain / Gamma-carboxyglutamic acid-rich (GLA) domain superfamily / Vitamin K-dependent carboxylation domain. / Gla domain profile. / Domain containing Gla (gamma-carboxyglutamate) residues. / Epidermal growth factor-like domain. / EGF-like domain profile. / EGF-like domain signature 2. / EGF-like domain signature 1. / EGF様ドメイン / Serine proteases, trypsin family, histidine active site / Serine proteases, trypsin family, serine active site / Peptidase S1A, chymotrypsin family / Serine proteases, trypsin family, histidine active site. / Serine proteases, trypsin domain profile. / Serine proteases, trypsin family, serine active site. / Trypsin-like serine protease / Serine proteases, trypsin domain / トリプシン / Peptidase S1, PA clan, chymotrypsin-like fold / Peptidase S1, PA clan 類似検索 - ドメイン・相同性 URIDINE-5'-DIPHOSPHATE / 第IX因子 / O-glucosyltransferase rumi 類似検索 - 構成要素生物種 Drosophila melanogaster (キイロショウジョウバエ)Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 2.15 Å 詳細データ登録者 Yu, H.J. / Li, H.L. 引用ジャーナル : Nat. Chem. Biol. / 年 : 2016タイトル : Structural analysis of Notch-regulating Rumi reveals basis for pathogenic mutations.著者 : Yu, H. / Takeuchi, H. / Takeuchi, M. / Liu, Q. / Kantharia, J. / Haltiwanger, R.S. / Li, H. 履歴 登録 2015年12月9日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2016年7月20日 Provider : repository / タイプ : Initial release改定 1.1 2018年4月18日 Group : Data collection / Database references / Derived calculationsカテゴリ : citation / citation_author / pdbx_struct_oper_listItem : _citation.country / _citation.journal_abbrev ... _citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year / _pdbx_struct_oper_list.symmetry_operation
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