登録情報 | データベース: PDB / ID: 4u5b |
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タイトル | Crystal structure of GluA2 A622T, con-ikot-ikot snail toxin, partial agonist KA and postitive modulator (R,R)-2b complex |
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要素 | - Con-ikot-ikot
- Glutamate receptor 2GRIA2
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キーワード | Transport protein/toxin / AMPA receptor (AMPA型グルタミン酸受容体) / Transport protein-toxin complex |
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機能・相同性 | 機能・相同性情報
host cell postsynaptic membrane / ion channel regulator activity / spine synapse / dendritic spine neck / dendritic spine head / Activation of AMPA receptors / response to lithium ion / perisynaptic space / cellular response to glycine / AMPA glutamate receptor activity ...host cell postsynaptic membrane / ion channel regulator activity / spine synapse / dendritic spine neck / dendritic spine head / Activation of AMPA receptors / response to lithium ion / perisynaptic space / cellular response to glycine / AMPA glutamate receptor activity / Trafficking of GluR2-containing AMPA receptors / immunoglobulin binding / AMPA glutamate receptor complex / kainate selective glutamate receptor activity / ionotropic glutamate receptor complex / extracellularly glutamate-gated ion channel activity / asymmetric synapse / regulation of receptor recycling / Unblocking of NMDA receptors, glutamate binding and activation / glutamate receptor binding / positive regulation of synaptic transmission / glutamate-gated receptor activity / presynaptic active zone membrane / response to fungicide / regulation of synaptic transmission, glutamatergic / cellular response to brain-derived neurotrophic factor stimulus / somatodendritic compartment / dendrite membrane / ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential / ionotropic glutamate receptor binding / ionotropic glutamate receptor signaling pathway / dendrite cytoplasm / cytoskeletal protein binding / SNARE binding / transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential / dendritic shaft / synaptic membrane / synaptic transmission, glutamatergic / PDZ domain binding / postsynaptic density membrane / protein tetramerization / modulation of chemical synaptic transmission / Schaffer collateral - CA1 synapse / establishment of protein localization / terminal bouton / receptor internalization / synaptic vesicle membrane / cerebral cortex development / シナプス小胞 / presynapse / signaling receptor activity / presynaptic membrane / amyloid-beta binding / 成長円錐 / toxin activity / perikaryon / chemical synaptic transmission / scaffold protein binding / postsynaptic membrane / 樹状突起スパイン / postsynaptic density / neuron projection / 神経繊維 / neuronal cell body / 樹状突起 / シナプス / glutamatergic synapse / protein-containing complex binding / endoplasmic reticulum membrane / protein kinase binding / 細胞膜 / 小胞体 / protein-containing complex / extracellular region / 生体膜 / identical protein binding / 細胞膜類似検索 - 分子機能 Four Helix Bundle (Hemerythrin (Met), subunit A) - #1800 / Bacterial extracellular solute-binding proteins, family 3 / Solute-binding protein family 3/N-terminal domain of MltF / Ionotropic glutamate receptor, metazoa / Ligated ion channel L-glutamate- and glycine-binding site / : / リガンド依存性イオンチャネル / Ionotropic glutamate receptor, L-glutamate and glycine-binding domain / Ligated ion channel L-glutamate- and glycine-binding site / Ionotropic glutamate receptor ...Four Helix Bundle (Hemerythrin (Met), subunit A) - #1800 / Bacterial extracellular solute-binding proteins, family 3 / Solute-binding protein family 3/N-terminal domain of MltF / Ionotropic glutamate receptor, metazoa / Ligated ion channel L-glutamate- and glycine-binding site / : / リガンド依存性イオンチャネル / Ionotropic glutamate receptor, L-glutamate and glycine-binding domain / Ligated ion channel L-glutamate- and glycine-binding site / Ionotropic glutamate receptor / Eukaryotic homologues of bacterial periplasmic substrate binding proteins. / Receptor, ligand binding region / Receptor family ligand binding region / Four Helix Bundle (Hemerythrin (Met), subunit A) / Periplasmic binding protein-like I / Up-down Bundle / Mainly Alpha類似検索 - ドメイン・相同性 Chem-FWF / 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE / Con-ikot-ikot / GRIA2類似検索 - 構成要素 |
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生物種 | Rattus norvegicus (ドブネズミ) Conus striatus (ニシキミナシ) |
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手法 | X線回折 / シンクロトロン / 解像度: 3.5037 Å |
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データ登録者 | Chen, L. / Gouaux, E. |
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引用 | ジャーナル: Science / 年: 2014 タイトル: X-ray structures of AMPA receptor-cone snail toxin complexes illuminate activation mechanism. 著者: Chen, L. / Durr, K.L. / Gouaux, E. |
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履歴 | 登録 | 2014年7月25日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2014年8月13日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2014年8月27日 | Group: Database references |
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改定 1.2 | 2014年10月1日 | Group: Database references |
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改定 1.3 | 2017年11月22日 | Group: Database references / Derived calculations ...Database references / Derived calculations / Other / Refinement description / Source and taxonomy / Structure summary カテゴリ: citation / entity ...citation / entity / entity_src_gen / pdbx_database_status / pdbx_struct_oper_list / software Item: _citation.journal_id_CSD / _entity.pdbx_description ..._citation.journal_id_CSD / _entity.pdbx_description / _entity_src_gen.pdbx_alt_source_flag / _pdbx_database_status.pdb_format_compatible / _pdbx_struct_oper_list.symmetry_operation / _software.classification |
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改定 1.4 | 2020年7月29日 | Group: Data collection / Derived calculations ...Data collection / Derived calculations / Refinement description / Structure summary カテゴリ: chem_comp / entity ...chem_comp / entity / pdbx_chem_comp_identifier / pdbx_entity_nonpoly / refine_hist / struct_conn / struct_site / struct_site_gen Item: _chem_comp.name / _chem_comp.type ..._chem_comp.name / _chem_comp.type / _entity.pdbx_description / _pdbx_entity_nonpoly.name / _struct_conn.pdbx_role 解説: Carbohydrate remediation / Provider: repository / タイプ: Remediation |
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改定 1.5 | 2023年12月27日 | Group: Data collection / Database references / Structure summary カテゴリ: chem_comp / chem_comp_atom ...chem_comp / chem_comp_atom / chem_comp_bond / database_2 Item: _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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