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Yorodumi- PDB-4u5c: Crystal structure of GluA2, con-ikot-ikot snail toxin, partial ag... -
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-Basic information
Entry | Database: PDB / ID: 4u5c | ||||||
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Title | Crystal structure of GluA2, con-ikot-ikot snail toxin, partial agonist FW and postitive modulator (R,R)-2b complex | ||||||
Components |
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Keywords | Transport protein/toxin / AMPA receptor / Transport protein-toxin complex | ||||||
Function / homology | Function and homology information host cell postsynaptic membrane / ion channel regulator activity / spine synapse / dendritic spine neck / dendritic spine head / Activation of AMPA receptors / perisynaptic space / ligand-gated monoatomic cation channel activity / AMPA glutamate receptor activity / Trafficking of GluR2-containing AMPA receptors ...host cell postsynaptic membrane / ion channel regulator activity / spine synapse / dendritic spine neck / dendritic spine head / Activation of AMPA receptors / perisynaptic space / ligand-gated monoatomic cation channel activity / AMPA glutamate receptor activity / Trafficking of GluR2-containing AMPA receptors / response to lithium ion / immunoglobulin binding / AMPA glutamate receptor complex / kainate selective glutamate receptor activity / ionotropic glutamate receptor complex / extracellularly glutamate-gated ion channel activity / cellular response to glycine / asymmetric synapse / regulation of receptor recycling / Unblocking of NMDA receptors, glutamate binding and activation / glutamate-gated calcium ion channel activity / positive regulation of synaptic transmission / glutamate receptor binding / extracellular ligand-gated monoatomic ion channel activity / glutamate-gated receptor activity / presynaptic active zone membrane / response to fungicide / regulation of synaptic transmission, glutamatergic / somatodendritic compartment / cellular response to brain-derived neurotrophic factor stimulus / dendrite membrane / ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential / cytoskeletal protein binding / ionotropic glutamate receptor signaling pathway / dendrite cytoplasm / SNARE binding / dendritic shaft / synaptic membrane / synaptic transmission, glutamatergic / PDZ domain binding / transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential / protein tetramerization / postsynaptic density membrane / ionotropic glutamate receptor binding / Schaffer collateral - CA1 synapse / establishment of protein localization / modulation of chemical synaptic transmission / receptor internalization / terminal bouton / cerebral cortex development / synaptic vesicle membrane / synaptic vesicle / presynapse / signaling receptor activity / presynaptic membrane / amyloid-beta binding / toxin activity / growth cone / scaffold protein binding / chemical synaptic transmission / perikaryon / postsynaptic membrane / dendritic spine / postsynaptic density / neuron projection / axon / neuronal cell body / glutamatergic synapse / dendrite / synapse / protein-containing complex binding / protein kinase binding / cell surface / endoplasmic reticulum / protein-containing complex / extracellular region / identical protein binding / membrane / plasma membrane Similarity search - Function | ||||||
Biological species | Rattus norvegicus (Norway rat) Conus striatus (striated cone) | ||||||
Method | X-RAY DIFFRACTION / SYNCHROTRON / Resolution: 3.6883 Å | ||||||
Authors | Chen, L. / Gouaux, E. | ||||||
Citation | Journal: Science / Year: 2014 Title: X-ray structures of AMPA receptor-cone snail toxin complexes illuminate activation mechanism. Authors: Chen, L. / Durr, K.L. / Gouaux, E. | ||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 4u5c.cif.gz | 1.2 MB | Display | PDBx/mmCIF format |
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PDB format | pdb4u5c.ent.gz | 1 MB | Display | PDB format |
PDBx/mmJSON format | 4u5c.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Summary document | 4u5c_validation.pdf.gz | 1.1 MB | Display | wwPDB validaton report |
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Full document | 4u5c_full_validation.pdf.gz | 1.2 MB | Display | |
Data in XML | 4u5c_validation.xml.gz | 109.5 KB | Display | |
Data in CIF | 4u5c_validation.cif.gz | 144.1 KB | Display | |
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/u5/4u5c ftp://data.pdbj.org/pub/pdb/validation_reports/u5/4u5c | HTTPS FTP |
-Related structure data
Related structure data | 4u5bC 4u5dC 4u5eC 4u5fC 4u5gC 4u5hC C: citing same article (ref.) |
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Similar structure data |
-Links
-Assembly
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Unit cell |
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Noncrystallographic symmetry (NCS) | NCS domain:
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