登録情報 データベース : PDB / ID : 4cff 構造の表示 ダウンロードとリンクタイトル Structure of full length human AMPK in complex with a small molecule activator, a thienopyridone derivative (A-769662) 要素(5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT ...) x 2 5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-2 詳細キーワード TRANSFERASE (転移酵素) / NUCLEOTIDE-BINDING / STAUROSPORINE-BINDING / SERINE/THREONINE-PROTEIN KINASE / ACTIVATOR / CARBOHYDRATE BINDING MODULE (CBM)機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase / nail development / [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity / : / regulation of stress granule assembly / histone H2BS36 kinase activity / AMPK inhibits chREBP transcriptional activation activity / positive regulation of peptidyl-lysine acetylation / lipid droplet disassembly / Lipophagy ... [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase / nail development / [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity / : / regulation of stress granule assembly / histone H2BS36 kinase activity / AMPK inhibits chREBP transcriptional activation activity / positive regulation of peptidyl-lysine acetylation / lipid droplet disassembly / Lipophagy / import into nucleus / cAMP-dependent protein kinase regulator activity / protein kinase regulator activity / Energy dependent regulation of mTOR by LKB1-AMPK / negative regulation of TOR signaling / Carnitine metabolism / negative regulation of hepatocyte apoptotic process / nucleotide-activated protein kinase complex / protein localization to lipid droplet / response to muscle activity / Activation of PPARGC1A (PGC-1alpha) by phosphorylation / Nuclear events mediated by NFE2L2 / regulation of glycolytic process / lipid biosynthetic process / cAMP-dependent protein kinase activity / negative regulation of tubulin deacetylation / オートファジー / AMP-activated protein kinase activity / positive regulation of protein localization / cholesterol biosynthetic process / AMP binding / cellular response to nutrient levels / positive regulation of macroautophagy / regulation of macroautophagy / positive regulation of protein kinase activity / cellular response to glucose starvation / fatty acid homeostasis / positive regulation of autophagy / Activation of AMPK downstream of NMDARs / regulation of microtubule cytoskeleton organization / energy homeostasis / negative regulation of TORC1 signaling / cellular response to calcium ion / protein serine/threonine/tyrosine kinase activity / positive regulation of glycolytic process / Translocation of SLC2A4 (GLUT4) to the plasma membrane / ADP binding / cellular response to glucose stimulus / TP53 Regulates Metabolic Genes / regulation of circadian rhythm / Wntシグナル経路 / オートファジー / cytoplasmic stress granule / cellular response to prostaglandin E stimulus / fatty acid biosynthetic process / rhythmic process / cellular response to xenobiotic stimulus / glucose homeostasis / cellular response to oxidative stress / positive regulation of cold-induced thermogenesis / 精子形成 / Regulation of TP53 Activity through Phosphorylation / non-specific serine/threonine protein kinase / protein kinase activity / intracellular signal transduction / nuclear speck / 神経繊維 / protein phosphorylation / negative regulation of gene expression / protein serine kinase activity / protein serine/threonine kinase activity / neuronal cell body / 樹状突起 / chromatin binding / positive regulation of gene expression / negative regulation of apoptotic process / protein kinase binding / ゴルジ体 / シグナル伝達 / 核質 / ATP binding / 生体膜 / metal ion binding / 細胞核 / 細胞質基質 / 細胞質 類似検索 - 分子機能 PRKAA2, UBA-like autoinhibitory domain / 5'-AMP-activated protein kinase catalytic subunit alpha-2, C-terminal / Kinase associated domain 1, KA1 / : / AMP-activated protein kinase, alpha subunit, autoinhibitory domain / Association with the SNF1 complex (ASC) domain / ASC domain superfamily / 5'-AMP-activated protein kinase beta subunit, interaction domain / 5'-AMP-activated protein kinase beta subunit, interation domain / AMPK, C-terminal adenylate sensor domain ... PRKAA2, UBA-like autoinhibitory domain / 5'-AMP-activated protein kinase catalytic subunit alpha-2, C-terminal / Kinase associated domain 1, KA1 / : / AMP-activated protein kinase, alpha subunit, autoinhibitory domain / Association with the SNF1 complex (ASC) domain / ASC domain superfamily / 5'-AMP-activated protein kinase beta subunit, interaction domain / 5'-AMP-activated protein kinase beta subunit, interation domain / AMPK, C-terminal adenylate sensor domain / Adenylate sensor of SNF1-like protein kinase / AMP-activated protein kinase, glycogen-binding domain / Glycogen recognition site of AMP-activated protein kinase / KA1 domain/Ssp2, C-terminal / TATA結合タンパク質 / CBS domain superfamily / Domain in cystathionine beta-synthase and other proteins. / CBSドメイン / CBSドメイン / CBS domain profile. / Immunoglobulin E-set / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / 抗体 / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Immunoglobulin-like fold / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / Immunoglobulin-like / サンドイッチ / 2-Layer Sandwich / Orthogonal Bundle / Mainly Beta / Mainly Alpha / Alpha Beta 類似検索 - ドメイン・相同性 アデニル酸 / Chem-C1V / スタウロスポリン / 5'-AMP-activated protein kinase subunit gamma-1 / 5'-AMP-activated protein kinase catalytic subunit alpha-2 / 5'-AMP-activated protein kinase subunit beta-1 類似検索 - 構成要素生物種 HOMO SAPIENS (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 3.924 Å 詳細データ登録者 Xiao, B. / Sanders, M.J. / Carmena, D. / Bright, N.J. / Haire, L.F. / Underwood, E. / Patel, B.R. / Heath, R.B. / Walker, P.A. / Hallen, S. ...Xiao, B. / Sanders, M.J. / Carmena, D. / Bright, N.J. / Haire, L.F. / Underwood, E. / Patel, B.R. / Heath, R.B. / Walker, P.A. / Hallen, S. / Giordanetto, F. / Martin, S.R. / Carling, D. / Gamblin, S.J. 引用ジャーナル : Nat.Commun. / 年 : 2013タイトル : Structural Basis of Ampk Regulation by Small Molecule Activators.著者 : Xiao, B. / Sanders, M.J. / Carmena, D. / Bright, N.J. / Haire, L.F. / Underwood, E. / Patel, B.R. / Heath, R.B. / Walker, P.A. / Hallen, S. / Giordanetto, F. / Martin, S.R. / Carling, D. / Gamblin, S.J. 履歴 登録 2013年11月14日 登録サイト : PDBE / 処理サイト : PDBE改定 1.0 2013年12月25日 Provider : repository / タイプ : Initial release改定 1.1 2014年1月8日 Group : Database references改定 1.2 2014年2月12日 Group : Data collection / Other / Refinement description改定 1.3 2019年5月8日 Group : Data collection / Derived calculations ... Data collection / Derived calculations / Experimental preparation / Other カテゴリ : database_PDB_rev / database_PDB_rev_record ... database_PDB_rev / database_PDB_rev_record / exptl_crystal_grow / pdbx_database_proc / pdbx_database_status / struct_conn Item : _exptl_crystal_grow.method / _pdbx_database_status.recvd_author_approval / _struct_conn.pdbx_leaving_atom_flag改定 1.4 2023年12月20日 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Other / Refinement description カテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_database_status / pdbx_initial_refinement_model / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_sf / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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