登録情報 | データベース: PDB / ID: 3gpq |
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タイトル | Crystal structure of macro domain of Chikungunya virus in complex with RNA |
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要素 | - Non-structural protein 3
- RNA (5'-R(*AP*AP*A)-3')
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キーワード | VIRAL PROTEIN/RNA (ウイルス性) / macro domain / X domain / Chikungunya (チクングニア熱) / alphavirus / virus (ウイルス) / VIZIER. Viral enzymes involved in replication / RNA (リボ核酸) / ATP-binding / Cell membrane (細胞膜) / Endosome (エンドソーム) / Helicase (ヘリカーゼ) / Hydrolase (加水分解酵素) / Lipoprotein (リポタンパク質) / Lysosome (リソソーム) / Membrane (生体膜) / Methyltransferase (メチルトランスフェラーゼ) / mRNA capping / mRNA processing (転写後修飾) / Multifunctional enzyme / Nucleotide-binding / Nucleotidyltransferase / Nucleus (Nucleus) / Palmitate (パルミチン酸) / Phosphoprotein / Protease (プロテアーゼ) / RNA replication (RNA依存性RNAポリメラーゼ) / RNA-binding / RNA-directed RNA polymerase (RNA依存性RNAポリメラーゼ) / Thiol protease (システインプロテアーゼ) / Transferase (転移酵素) / VIRAL PROTEIN-RNA complex (ウイルス性) |
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機能・相同性 | 機能・相同性情報
host cell filopodium / ADP-ribose 1''-phosphate phosphatase / mRNA methyltransferase activity / mRNA 5'-triphosphate monophosphatase activity / mRNA 5'-phosphatase / polynucleotide 5'-phosphatase activity / polynucleotide adenylyltransferase / poly(A) RNA polymerase activity / regulation of cytoskeleton organization / symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity ...host cell filopodium / ADP-ribose 1''-phosphate phosphatase / mRNA methyltransferase activity / mRNA 5'-triphosphate monophosphatase activity / mRNA 5'-phosphatase / polynucleotide 5'-phosphatase activity / polynucleotide adenylyltransferase / poly(A) RNA polymerase activity / regulation of cytoskeleton organization / symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity / 7-methylguanosine mRNA capping / symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT1 activity / cysteine-type peptidase activity / 転移酵素; 一炭素原子の基を移すもの; メチル基を移すもの / host cell cytoplasmic vesicle membrane / 転移酵素; リンを含む基を移すもの; 核酸を移すもの / nucleoside-triphosphate phosphatase / 加水分解酵素; プロテアーゼ; ペプチド結合加水分解酵素; システインプロテアーゼ / RNA helicase activity / ヘリカーゼ / RNA依存性RNAポリメラーゼ / viral RNA genome replication / RNA-dependent RNA polymerase activity / DNA-templated transcription / symbiont-mediated suppression of host type I interferon-mediated signaling pathway / host cell nucleus / GTP binding / host cell plasma membrane / ATP hydrolysis activity / タンパク質分解 / RNA binding / ATP binding / 生体膜 / metal ion binding類似検索 - 分子機能 : / : / : / Non-structural protein 3, zinc-binding domain / Tomato mosaic virus helicase, N-terminal domain / Alphavirus nsP2 protease domain superfamily / Alphavirus nsp2 protease (nsp2pro) domain / Peptidase family C9 / Alphavirus nsp2 protease (nsp2pro) domain profile. / Viral methyltransferase ...: / : / : / Non-structural protein 3, zinc-binding domain / Tomato mosaic virus helicase, N-terminal domain / Alphavirus nsP2 protease domain superfamily / Alphavirus nsp2 protease (nsp2pro) domain / Peptidase family C9 / Alphavirus nsp2 protease (nsp2pro) domain profile. / Viral methyltransferase / Alphavirus-like methyltransferase (MT) domain / Alphavirus-like methyltransferase (MT) domain profile. / Tymovirus, RNA-dependent RNA polymerase / RNA依存性RNAポリメラーゼ / Leucine Aminopeptidase, subunit E, domain 1 / Leucine Aminopeptidase, subunit E; domain 1 / Viral (Superfamily 1) RNA helicase / (+) RNA virus helicase core domain / (+)RNA virus helicase core domain profile. / Non-structural protein 3, X-domain-like / Macro domain / Appr-1"-p processing enzyme / Macro domain / Macro domain profile. / Macro domain-like / RNA-directed RNA polymerase, catalytic domain / RdRp of positive ssRNA viruses catalytic domain profile. / S-adenosyl-L-methionine-dependent methyltransferase superfamily / DNA/RNA polymerase superfamily / P-loop containing nucleoside triphosphate hydrolase / 3-Layer(aba) Sandwich / Alpha Beta類似検索 - ドメイン・相同性 |
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生物種 | Chikungunya virus (チクングニヤウイルス) |
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手法 | X線回折 / シンクロトロン / 解像度: 2 Å |
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データ登録者 | Malet, H. / Jamal, S. / Coutard, B. / Canard, B. |
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引用 | ジャーナル: J.Virol. / 年: 2009 タイトル: The crystal structures of Chikungunya and Venezuelan equine encephalitis virus nsP3 macro domains define a conserved adenosine binding pocket 著者: Malet, H. / Coutard, B. / Jamal, S. / Dutartre, H. / Papageorgiou, N. / Neuvonen, M. / Ahola, T. / Forrester, N. / Gould, E.A. / Lafitte, D. / Ferron, F. / Lescar, J. / Gorbalenya, A.E. / de ...著者: Malet, H. / Coutard, B. / Jamal, S. / Dutartre, H. / Papageorgiou, N. / Neuvonen, M. / Ahola, T. / Forrester, N. / Gould, E.A. / Lafitte, D. / Ferron, F. / Lescar, J. / Gorbalenya, A.E. / de Lamballerie, X. / Canard, B. |
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履歴 | 登録 | 2009年3月23日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2009年7月21日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2011年7月13日 | Group: Advisory / Refinement description / Version format compliance |
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改定 1.2 | 2023年9月6日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_ref_seq_dif Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details |
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