登録情報 | データベース: PDB / ID: 2msr |
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タイトル | Solution structure of LEDGF/p75 IBD in complex with MLL1 peptide (140-160) |
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要素 | - Histone-lysine N-methyltransferase 2A
- PC4 and SFRS1-interacting protein
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キーワード | PROTEIN BINDING (タンパク質) / LEDGF/p75 / MLL / Mixed Lineage Leukemia |
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機能・相同性 | 機能・相同性情報
protein-cysteine methyltransferase activity / response to potassium ion / [histone H3]-lysine4 N-methyltransferase / histone H3K4 monomethyltransferase activity / unmethylated CpG binding / histone H3K4 trimethyltransferase activity / negative regulation of DNA methylation-dependent heterochromatin formation / regulation of short-term neuronal synaptic plasticity / definitive hemopoiesis / histone H3K4 methyltransferase activity ...protein-cysteine methyltransferase activity / response to potassium ion / [histone H3]-lysine4 N-methyltransferase / histone H3K4 monomethyltransferase activity / unmethylated CpG binding / histone H3K4 trimethyltransferase activity / negative regulation of DNA methylation-dependent heterochromatin formation / regulation of short-term neuronal synaptic plasticity / definitive hemopoiesis / histone H3K4 methyltransferase activity / T-helper 2 cell differentiation / supercoiled DNA binding / embryonic hemopoiesis / anterior/posterior pattern specification / exploration behavior / Integration of viral DNA into host genomic DNA / Autointegration results in viral DNA circles / histone methyltransferase complex / : / Formation of WDR5-containing histone-modifying complexes / 2-LTR circle formation / Vpr-mediated nuclear import of PICs / minor groove of adenine-thymine-rich DNA binding / Integration of provirus / 脱分極 / APOBEC3G mediated resistance to HIV-1 infection / MLL1 complex / mRNA 5'-splice site recognition / ヘテロクロマチン / negative regulation of fibroblast proliferation / homeostasis of number of cells within a tissue / spleen development / transcription initiation-coupled chromatin remodeling / cellular response to transforming growth factor beta stimulus / 転移酵素; 一炭素原子の基を移すもの; メチル基を移すもの / nuclear periphery / post-embryonic development / circadian regulation of gene expression / protein modification process / lysine-acetylated histone binding / ユークロマチン / visual learning / RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function / PKMTs methylate histone lysines / Transcriptional regulation of granulopoiesis / RUNX1 regulates transcription of genes involved in differentiation of HSCs / response to heat / fibroblast proliferation / protein-containing complex assembly / DNA-binding transcription factor binding / response to oxidative stress / transcription coactivator activity / クロマチンリモデリング / apoptotic process / chromatin binding / positive regulation of DNA-templated transcription / protein homodimerization activity / positive regulation of transcription by RNA polymerase II / RNA binding / zinc ion binding / 核質 / identical protein binding / 細胞核 / 細胞質基質類似検索 - 分子機能 Lens epithelium-derived growth factor, integrase-binding domain / HIV integrase-binding domain superfamily / Lens epithelium-derived growth factor (LEDGF) / KMT2A, ePHD domain / KMT2A, PHD domain 1 / KMT2A, PHD domain 2 / KMT2A, PHD domain 3 / Methyltransferase, trithorax / : / FY-rich, N-terminal ...Lens epithelium-derived growth factor, integrase-binding domain / HIV integrase-binding domain superfamily / Lens epithelium-derived growth factor (LEDGF) / KMT2A, ePHD domain / KMT2A, PHD domain 1 / KMT2A, PHD domain 2 / KMT2A, PHD domain 3 / Methyltransferase, trithorax / : / FY-rich, N-terminal / F/Y-rich N-terminus / PHD-like zinc-binding domain / FYR domain FYRN motif profile. / "FY-rich" domain, N-terminal region / FY-rich, C-terminal / F/Y rich C-terminus / FYR domain FYRC motif profile. / "FY-rich" domain, C-terminal region / CXXC zinc finger domain / Zinc finger, CXXC-type / Zinc finger CXXC-type profile. / TFIIS/LEDGF domain superfamily / Cysteine-rich motif following a subset of SET domains / Post-SET domain / Post-SET domain profile. / SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain / SET domain superfamily / SET domain / SET domain profile. / SET domain / Extended PHD (ePHD) domain / Extended PHD (ePHD) domain profile. / domain with conserved PWWP motif / PWWP domain / PWWP domain profile. / PWWP domain / PHD-finger / Zinc finger PHD-type signature. / Zinc finger PHD-type profile. / Zinc finger, PHD-finger / Zinc finger, PHD-type / PHD zinc finger / Zinc finger, FYVE/PHD-type / Bromodomain profile. / bromo domain / ブロモドメイン / Bromodomain-like superfamily / Zinc finger, RING/FYVE/PHD-type類似検索 - ドメイン・相同性 PC4 and SFRS1-interacting protein / Histone-lysine N-methyltransferase 2A類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | 溶液NMR / torsion angle dynamics, molecular dynamics |
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Model details | closest to the average, model2 |
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データ登録者 | Cermakova, K. / Tesina, P. / Demeulemeester, J. / El Ashkar, S. / Mereau, H. / Schwaller, J. / Rezacova, P. / Veverka, V. / De Rijck, J. |
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引用 | ジャーナル: Cancer Res. / 年: 2014 タイトル: Validation and Structural Characterization of the LEDGF/p75-MLL Interface as a New Target for the Treatment of MLL-Dependent Leukemia. 著者: Cermakova, K. / Tesina, P. / Demeulemeester, J. / El Ashkar, S. / Mereau, H. / Schwaller, J. / Rezacova, P. / Veverka, V. / De Rijck, J. |
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履歴 | 登録 | 2014年8月5日 | 登録サイト: BMRB / 処理サイト: RCSB |
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改定 1.0 | 2014年8月20日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2014年10月8日 | Group: Database references |
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改定 1.2 | 2023年6月14日 | Group: Data collection / Database references / Other カテゴリ: database_2 / pdbx_database_status ...database_2 / pdbx_database_status / pdbx_nmr_software / pdbx_nmr_spectrometer / struct_ref_seq_dif Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_nmr_data / _pdbx_nmr_software.name / _pdbx_nmr_spectrometer.model / _struct_ref_seq_dif.details |
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改定 1.3 | 2024年5月15日 | Group: Data collection / Database references / カテゴリ: chem_comp_atom / chem_comp_bond / database_2 / Item: _database_2.pdbx_DOI |
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